Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. (Q47763676)

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English	Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.	scientific article

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27 December 2019

Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease (English)

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27 December 2019

Alzheimer's disease

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phosphorylation

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Dennis W. Dickson

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27 December 2019

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Mikio Shoji

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Steven G. Younkin

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Steven G Younkin

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27 December 2019

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Takeshi Kawarabayashi

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27 December 2019

Linda H Younkin

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27 December 2019

Lin Wen-Lang

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27 December 2019

Tetsuro Murakami

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27 December 2019

Etsuro Matsubara

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27 December 2019

Koji Abe

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27 December 2019

Karen Hsiao Ashe

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1 April 2004

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27 December 2019

Journal of Neuroscience

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27 December 2019

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27 December 2019

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27 December 2019

3801-3809

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27 December 2019

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detergent-insoluble glycosphingolipid/cholesterol-rich membrane domains, lipid rafts and caveolae (review).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta protein (Abeta) starts to deposit as plasma membrane-bound form in diffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis-Dutch type, Alzheimer disease and nondemented aged subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: genes, proteins, and therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid rafts and signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of APP in the early stage of brain damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic and renal expression of rat apolipoprotein E under control of the metallothionein promoter in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fibrillogenesis in Alzheimer's disease of amyloid beta peptides and apolipoprotein E.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlations of synaptic and pathological markers with cognition of the elderly

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modified amyloid beta protein ending at 42 or 40 with different solubility accumulates in the brain of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ultrastructural localization of gangliosides; GM1 is concentrated in caveolae

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transducing molecules and glycosyl-phosphatidylinositol-linked proteins form a caveolin-rich insoluble complex in MDCK cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional rafts in cell membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acceleration of Amyloid Fibril Formation by Specific Binding of Aβ-(1–40) Peptide to Ganglioside-containing Membrane Vesicles

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid Binding to Amyloid β‐Peptide Aggregates: Preferential Binding of Cholesterol as Compared with Phosphatidylcholine and Fatty Acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of Tau by Lysosomal Enzyme Cathepsin D: Implication for Alzheimer Neurofibrillary Degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid β‐protein deposition in the leptomeninges and cerebral cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A detergent-insoluble membrane compartment contains A beta in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Presence of Amyloid β-Protein in the Detergent-Insoluble Membrane Compartment of Human Neuroblastoma Cells†

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functions of lipid rafts in biological membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during aging

1 reference

https://pubmed.ncbi.nlm.nih.gov/15084661

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.5543-03.2004

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15084661 AND SRC:MED&resulttype=core&format=json

27 December 2019

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15084661 AND SRC:MED&resulttype=core&format=json

27 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15084661 AND SRC:MED&resulttype=core&format=json

27 December 2019

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