Towards a better understanding of the cannabinoid-related orphan receptors GPR3, GPR6, and GPR12. (Q47698731)

4 February 2018

title

Towards a better understanding of the cannabinoid-related orphan receptors GPR3, GPR6, and GPR12. (English)

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4 February 2018

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Israa Isawi

2

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Paula Morales

object named as

Paula Morales

series ordinal

1

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author name string

Patricia H Reggio

series ordinal

3

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4 February 2018

language of work or name

English

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publication date

1 February 2018

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4 February 2018

published in

Drug Metabolism Reviews

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4 February 2018

volume

50

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11 September 2019

issue

1

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11 September 2019

page(s)

1-20

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4 February 2018

Proteins involved in the activation and control of the two pathways of human complement

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Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system

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Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors

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Molecular characterization of the human interleukin (IL)-17 receptor

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Goal-directed instrumental action: contingency and incentive learning and their cortical substrates

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Prior Exposure to Neurotrophins Blocks Inhibition of Axonal Regeneration by MAG and Myelin via a cAMP-Dependent Mechanism

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Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors

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Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development

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Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells

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The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

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Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2 release by activating the sphingosine-kinase pathway

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Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase.

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Maintenance of meiotic prophase arrest in vertebrate oocytes by a Gs protein-mediated pathway

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Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons.

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Pathways towards and away from Alzheimer's disease

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The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes

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The repertoire of G-protein-coupled receptors in fully sequenced genomes

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Premature ovarian aging in mice deficient for Gpr3.

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The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes

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Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a constitutive activator of the Gs G protein

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Neural bases of food-seeking: affect, arousal and reward in corticostriatolimbic circuits.

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Oocyte-specific expression of Gpr3 is required for the maintenance of meiotic arrest in mouse oocytes

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G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice

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Identification of nesfatin-1 as a satiety molecule in the hypothalamus

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Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth

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Intracellular amyloid-beta in Alzheimer's disease

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Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain

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Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse

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Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6.

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Oocyte-specific G-protein-coupled receptor 3 (GPR3): no perturbations found in 82 women with premature ovarian failure (first report).

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Complement component C1q inhibits beta-amyloid- and serum amyloid P-induced neurotoxicity via caspase- and calpain-independent mechanisms.

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Meiotic arrest in human oocytes is maintained by a Gs signaling pathway

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Parkinson's disease: clinical features and diagnosis

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A role for GPRx, a novel GPR3/6/12-related G-protein coupled receptor, in the maintenance of meiotic arrest in Xenopus laevis oocytes

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12 December 2020

The complement cascade: Yin-Yang in neuroinflammation--neuro-protection and -degeneration

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12 December 2020

GPR12 selections of the metabolites from an endophytic Streptomyces sp. associated with Cistanches deserticola

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12 December 2020

Classical inhibitors of NOX NAD(P)H oxidases are not specific.

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12 December 2020

Anatomical profiling of G protein-coupled receptor expression

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12 December 2020

A translational profiling approach for the molecular characterization of CNS cell types

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12 December 2020

Striatal plasticity and basal ganglia circuit function

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12 December 2020

Constitutively active GPR6 is located in the intracellular compartments

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12 December 2020

The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons

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12 December 2020

GPR3 receptor, a novel actor in the emotional-like responses

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12 December 2020

Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay

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12 December 2020

The Gs-linked receptor GPR3 inhibits the proliferation of cerebellar granule cells during postnatal development

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12 December 2020

BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV.

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12 December 2020

Signaling involved in neurite outgrowth of postnatally born subventricular zone neurons in vitro

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12 December 2020

GPR3 may not be a potential candidate gene for premature ovarian failure

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12 December 2020

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12 December 2020

Neurogenetics and pharmacology of learning, motivation, and cognition

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12 December 2020

Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease

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12 December 2020

Levodopa-induced dyskinesias in patients with Parkinson's disease: filling the bench-to-bedside gap.

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12 December 2020

Methods to detect cell surface expression and constitutive activity of GPR6

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12 December 2020

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂

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12 December 2020

Huntington's disease: a clinical review

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12 December 2020

Is Older Colder or Colder Older? The Association of Age With Body Temperature in 18,630 Individuals

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12 December 2020

GPR3 orphan receptor is involved in neuropathic pain after peripheral nerve injury and regulates morphine-induced antinociception.

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12 December 2020

Complement Protein C1q-Mediated Neuroprotection Is Correlated with Regulation of Neuronal Gene and MicroRNA Expression

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12 December 2020

Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma

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12 December 2020

Endocytosis in the mouse oocyte and its contribution to cAMP signaling during meiotic arrest

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12 December 2020

Biomarkers of disease activity in multiple sclerosis

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12 December 2020

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

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12 December 2020

Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.

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12 December 2020

Involvement of GPR12 in the induction of neurite outgrowth in PC12 cells

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12 December 2020

Reassessment of blood gene expression markers for the prognosis of relapsing-remitting multiple sclerosis

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12 December 2020

Involvement of GPR12 in the regulation of cell proliferation and survival

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12 December 2020

How much of reinforcement learning is working memory, not reinforcement learning? A behavioral, computational, and neurogenetic analysis

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12 December 2020

The orphan receptor GPR3 modulates the early phases of cocaine reinforcement.

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12 December 2020

Molecular control of oogenesis.

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12 December 2020

The G protein coupled receptor 3 is involved in cAMP and cGMP signaling and maintenance of meiotic arrest in porcine oocytes.

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12 December 2020

Sphingosine 1-phosphate acts as an activator for the porcine Gpr3 of constitutively active G protein-coupled receptors

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12 December 2020

Metabolic parameters and emotionality are little affected in G-protein coupled receptor 12 (Gpr12) mutant mice

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12 December 2020

Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue

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12 December 2020

C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity

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12 December 2020

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease

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12 December 2020

Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors

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12 December 2020

The road to maturation: somatic cell interaction and self-organization of the mammalian oocyte

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12 December 2020

Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells

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12 December 2020

Anatomical transcriptome of G protein-coupled receptors leads to the identification of a novel therapeutic candidate GPR52 for psychiatric disorders

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12 December 2020

Identification of a novel small-molecule agonist for human G protein-coupled receptor 3.

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12 December 2020

G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease

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12 December 2020

Developmental expression of GPR3 in rodent cerebellar granule neurons is associated with cell survival and protects neurons from various apoptotic stimuli

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12 December 2020

Schizophrenia: overview and treatment options

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12 December 2020

Role for endocytosis of a constitutively active GPCR (GPR185) in releasing vertebrate oocyte meiotic arrest

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12 December 2020

The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function

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12 December 2020

Emerging and Novel Functions of Complement Protein C1q

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12 December 2020

Constitutive Activity among Orphan Class-A G Protein Coupled Receptors

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12 December 2020

Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue

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12 December 2020

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models

1 reference

12 December 2020

Disease-modifying treatments for multiple sclerosis - a review of approved medications

1 reference

12 December 2020

The Subcellular Dynamics of the Gs-Linked Receptor GPR3 Contribute to the Local Activation of PKA in Cerebellar Granular Neurons

1 reference

12 December 2020

A gene expression study denies the ability of 25 candidate biomarkers to predict the interferon-beta treatment response in multiple sclerosis patients

1 reference

12 December 2020

Increased susceptibility of G-protein coupled receptor 6 deficient mice to MPTP neurotoxicity

1 reference

12 December 2020

Nesfatin-1: functions and physiology of a novel regulatory peptide

1 reference

12 December 2020

Molecular Targets of the Phytocannabinoids: A Complex Picture

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12 December 2020

In vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer's Disease

1 reference

12 December 2020

Altered enhancer transcription underlies Huntington's disease striatal transcriptional signature

1 reference

12 December 2020

Cannabidiol: State of the art and new challenges for therapeutic applications

1 reference

12 December 2020

GPR3 and GPR6, novel molecular targets for cannabidiol

1 reference

12 December 2020

Methods for the Development of In Silico GPCR Models

1 reference

12 December 2020

Pharmacogenetic Biomarkers to Predict Treatment Response in Multiple Sclerosis: Current and Future Perspectives.

1 reference

12 December 2020

The involvement of DARPP-32 in the pathophysiology of schizophrenia

1 reference

12 December 2020

Cannabidiol, a novel inverse agonist for GPR12.

1 reference

12 December 2020

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors

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12 December 2020

10.1080/03602532.2018.1428616

Identifiers

DOI

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4 February 2018

PMC publication ID

6093286

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1 reference

4 February 2018