Chapter 8. Activation mechanisms of chemokine receptors (Q47694355)

4 February 2018

title

Chapter 8. Activation mechanisms of chemokine receptors (English)

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4 February 2018

Mette M Rosenkilde

2

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author name string

Pia C Jensen

series ordinal

1

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4 February 2018

language of work or name

English

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publication date

1 January 2009

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4 February 2018

published in

Methods in Enzymology

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4 February 2018

volume

461

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4 February 2018

page(s)

171-190

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4 February 2018

Modulation of GDP release from transducin by the conserved Glu134-Arg135 sequence in rhodopsin

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Chemokine: receptor structure, interactions, and antagonism

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7 January 2021

Structural features and light-dependent changes in the sequence 306-322 extending from helix VII to the palmitoylation sites in rhodopsin: a site-directed spin-labeling study

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7 January 2021

High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation

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7 January 2021

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

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7 January 2021

Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist

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7 January 2021

CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach

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7 January 2021

G protein-coupled receptor allosterism and complexing

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7 January 2021

Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha

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7 January 2021

Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins

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7 January 2021

Chimeric G proteins allow a high-throughput signaling assay of Gi-coupled receptors

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7 January 2021

Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity

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7 January 2021

Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation

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7 January 2021

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

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7 January 2021

Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation

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7 January 2021

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

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7 January 2021

Chemokine receptors: attractive targets for drug discovery

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7 January 2021

Mutational analysis of the R33-encoded G protein-coupled receptor of rat cytomegalovirus: identification of amino acid residues critical for cellular localization and ligand-independent signalling

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7 January 2021

A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

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7 January 2021

Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8.

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7 January 2021

Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors

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7 January 2021

Common structural basis for constitutive activity of the ghrelin receptor family

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7 January 2021

Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking

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7 January 2021

The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

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7 January 2021

Activation of muscarinic acetylcholine receptors via their allosteric binding sites.

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7 January 2021

Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8

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7 January 2021

Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

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7 January 2021

A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus.

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7 January 2021

Application of a Theory of Enzyme Specificity to Protein Synthesis

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7 January 2021

Is Galpha16 the optimal tool for fishing ligands of orphan G-protein-coupled receptors?

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7 January 2021

Functional characterization of a series of mutant G protein alphaq subunits displaying promiscuous receptor coupling properties

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7 January 2021

High Affinity Agonistic Metal Ion Binding Sites within the Melanocortin 4 Receptor Illustrate Conformational Change of Transmembrane Region 3

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7 January 2021

The role of the aspartate-arginine-tyrosine triad in the m1 muscarinic receptor: mutations of aspartate 122 and tyrosine 124 decrease receptor expression but do not abolish signaling

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7 January 2021

Chemokines — Chemotactic Cytokines That Mediate Inflammation

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7 January 2021

Influence of proline residues on protein conformation

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7 January 2021

Allosteric Modulation of G Protein–Coupled Receptors

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7 January 2021

Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin

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7 January 2021

Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle

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7 January 2021

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

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7 January 2021

GLIDA: GPCR--ligand database for chemical genomics drug discovery--database and tools update

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7 January 2021

Crystal structure of rhodopsin: A G protein-coupled receptor

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7 January 2021

Crystal structure of the ligand-free G-protein-coupled receptor opsin

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7 January 2021

Coupling of retinal isomerization to the activation of rhodopsin

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7 January 2021

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

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7 January 2021

The clinical potential of chemokine receptor antagonists

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7 January 2021

Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI

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7 January 2021

Conformational constraining of inactive and active States of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V.

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7 January 2021

High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3.

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7 January 2021

Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor

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7 January 2021

GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors

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https://api.crossref.org/works/10.1016/S0076-6879(09)05408-1

7 January 2021

Crystal structure of opsin in its G-protein-interacting conformation

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(09)05408-1

7 January 2021

Molecular mechanism of 7TM receptor activation--a global toggle switch model

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https://api.crossref.org/works/10.1016/S0076-6879(09)05408-1

7 January 2021

Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(09)05408-1

7 January 2021

Is there a 'lock' for all agonist 'keys' in 7TM receptors?

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(09)05408-1

7 January 2021

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(09)05408-1

7 January 2021

The activation mechanism of chemokine receptor CCR5 involves common structural changes but a different network of interhelical interactions relative to rhodopsin

1 reference

https://api.crossref.org/works/10.1016/S0076-6879(09)05408-1

7 January 2021

Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide

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7 January 2021

Structure of a beta1-adrenergic G-protein-coupled receptor

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7 January 2021

The CCR5 receptor-based mechanism of action of 873140, a potent allosteric noncompetitive HIV entry inhibitor

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7 January 2021

Molecular basis of receptor/G-protein-coupling selectivity

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7 January 2021

10.1016/S0076-6879(09)05408-1

Identifiers

DOI

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4 February 2018

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4 February 2018