Decreasing the Expression of GABAA α5 Subunit-Containing Receptors Partially Improves Cognitive, Electrophysiological, and Morphological Hippocampal Defects in the Ts65Dn Model of Down Syndrome. (Q47666263)

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English	Decreasing the Expression of GABAA α5 Subunit-Containing Receptors Partially Improves Cognitive, Electrophysiological, and Morphological Hippocampal Defects in the Ts65Dn Model of Down Syndrome.	scientific article

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25 March 2020

Decreasing the Expression of GABAA α5 Subunit-Containing Receptors Partially Improves Cognitive, Electrophysiological, and Morphological Hippocampal Defects in the Ts65Dn Model of Down Syndrome (English)

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Susana García-Cerro

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Carmen Martínez-Cué

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Verónica Vidal

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Paula Martínez

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Andrea Corrales

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Sara Lantigua

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Rebeca Vidal

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Noemí Rueda

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Laurence Ozmen

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Maria-Clemencia Hernández

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17 July 2017

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Molecular Neurobiology

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4745-4762

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25 March 2020

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GABA receptors containing the alpha5 subunit mediate the trace effect in aversive and appetitive conditioning and extinction of conditioned fear

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Cognitive enhancement by pharmacological and behavioral interventions: the murine Down syndrome model

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L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for alpha5-containing GABAA receptors.

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Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome

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Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome

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Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.

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Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome.

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GABAergic hyperinnervation of dentate granule cells in the Ts65Dn mouse model of down syndrome: Exploring the role of App.

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Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome

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Short-term treatment with the GABAA receptor antagonist pentylenetetrazole produces a sustained pro-cognitive benefit in a mouse model of Down's syndrome

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Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome.

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Involvement of subcortical and cortical afferents to the lateral nucleus of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli

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Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus

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The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development

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1 reference

https://pubmed.ncbi.nlm.nih.gov/28717969

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benzodiazepines and human memory: a review.

1 reference

https://pubmed.ncbi.nlm.nih.gov/28717969

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12035-017-0675-3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28717969 AND SRC:MED&resulttype=core&format=json

25 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28717969 AND SRC:MED&resulttype=core&format=json

25 March 2020

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