Prying into the Prion Hypothesis for Parkinson's Disease (Q47665674)

3 July 2018

title

Prying into the Prion Hypothesis for Parkinson's Disease (English)

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3 July 2018

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1 reference

1

Patrik Brundin

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3 July 2018

2

Ronald Melki

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3 July 2018

language of work or name

English

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publication date

1 October 2017

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3 July 2018

published in

Journal of Neuroscience

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3 July 2018

volume

37

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3 July 2018

issue

41

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3 July 2018

page(s)

9808-9818

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3 July 2018

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

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ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.

10 July 2018

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10 July 2018

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10 July 2018

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Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein

10 July 2018

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The Concept of Prodromal Parkinson's Disease

10 July 2018

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Depletion of microglia and inhibition of exosome synthesis halt tau propagation

10 July 2018

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Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

10 July 2018

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α-synuclein assemblies sequester neuronal α3-Na /K -ATPase and impair Na gradient

10 July 2018

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Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease

10 July 2018

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Post-translational modification of α-synuclein in Parkinson's disease

10 July 2018

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α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

10 July 2018

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Formation and Implications of Alpha-Synuclein Radical in Maneb- and Paraquat-Induced Models of Parkinson's Disease

10 July 2018

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10 July 2018

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Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease.

10 July 2018

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A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease

10 July 2018

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Clinical correlations with Lewy body pathology in LRRK2-related Parkinson disease

10 July 2018

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ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein

10 July 2018

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Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

10 July 2018

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Interactions between calcium and alpha-synuclein in neurodegeneration

10 July 2018

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Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

10 July 2018

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10 July 2018

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Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice.

10 July 2018

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10 July 2018

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Defined α-synuclein prion-like molecular assemblies spreading in cell culture

10 July 2018

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Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

10 July 2018

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Prion protein misfolding, strains, and neurotoxicity: an update from studies on Mammalian prions

10 July 2018

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10 July 2018

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The role of oxidative stress in Parkinson's disease

10 July 2018

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Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein

10 July 2018

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Transmission of multiple system atrophy prions to transgenic mice

10 July 2018

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Structural and functional characterization of two alpha-synuclein strains

10 July 2018

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10 July 2018

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10 July 2018

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10 July 2018

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10 July 2018

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10 July 2018

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Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis

10 July 2018

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Parkin disease: a clinicopathologic entity?

10 July 2018

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Lewy pathology is not the first sign of degeneration in vulnerable neurons in Parkinson disease

10 July 2018

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10 July 2018

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Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson's disease

10 July 2018

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α-Synuclein and protein degradation systems: a reciprocal relationship

10 July 2018

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Exosomal cell-to-cell transmission of alpha synuclein oligomers.

10 July 2018

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A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

10 July 2018

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Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo

10 July 2018

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Inflammation and α-synuclein's prion-like behavior in Parkinson's disease--is there a link?

10 July 2018

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Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

10 July 2018

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The heat shock response: systems biology of proteotoxic stress in aging and disease

10 July 2018

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10 July 2018

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Parkinson's disease and α-synuclein expression

10 July 2018

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Cellular strategies of protein quality control

10 July 2018

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Neuropathology underlying clinical variability in patients with synucleinopathies

10 July 2018

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Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat

10 July 2018

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The stress of protein misfolding: from single cells to multicellular organisms

10 July 2018

1 reference

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Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.

10 July 2018

1 reference

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α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

10 July 2018

1 reference

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Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

10 July 2018

1 reference

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Role of matrix metalloproteinase-3 in neurodegeneration

10 July 2018

1 reference

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The challenge of non-motor symptoms in Parkinson's disease

10 July 2018

1 reference

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Are synucleinopathies prion-like disorders?

10 July 2018

1 reference

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Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

10 July 2018

1 reference

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Prion-like transmission of protein aggregates in neurodegenerative diseases

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.

10 July 2018

1 reference

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Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?

10 July 2018

1 reference

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Tickets to ride: selecting cargo for clathrin-regulated internalization.

10 July 2018

1 reference

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Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

10 July 2018

1 reference

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Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

10 July 2018

1 reference

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Neuroinflammation in Parkinson's disease: a target for neuroprotection?

10 July 2018

1 reference

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Neuroanatomy and pathology of sporadic Parkinson's disease.

10 July 2018

1 reference

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A critical evaluation of the Braak staging scheme for Parkinson's disease.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Research in motion: the enigma of Parkinson's disease pathology spread

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Mechanisms of membrane fusion: disparate players and common principles.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Clearance and deposition of extracellular alpha-synuclein aggregates in microglia.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Parkinson's disease: a dual-hit hypothesis

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Ubiquitination of alpha-synuclein.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

The neuromythology of Parkinson's Disease

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Staging of brain pathology related to sporadic Parkinson's disease

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Induction of alpha-synuclein aggregation by intracellular nitrative insult.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

α-Synuclein in Lewy bodies

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Lewy body extracts from Parkinson disease brains trigger α-synuclein pathology and neurodegeneration in mice and monkeys.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Generation of ferric iron links oxidative stress to α-synuclein oligomer formation

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

100 years of Lewy pathology

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Prion-like acceleration of a synucleinopathy in a transgenic mouse model

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5637113

Mitochondrial dysfunction in Parkinson's disease

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29021298

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/29021298

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1523/JNEUROSCI.1788-16.2017

1 reference

3 July 2018

PMC publication ID

5637113

1 reference

3 July 2018

PubMed publication ID

29021298

1 reference

3 July 2018