Are sigma receptor modulators a weapon against multiple sclerosis disease? (Q47596098)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29076758 AND SRC:MED&resulttype=core&format=json

8 April 2020

title

Are sigma receptor modulators a weapon against multiple sclerosis disease? (English)

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8 April 2020

3

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8 April 2020

Guido Cavaletti

10

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8 April 2020

author name string

Simona Collina

1

1 reference

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8 April 2020

Marta Rui

2

1 reference

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8 April 2020

Emanuele Bignardi

4

1 reference

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8 April 2020

Daniela Rossi

5

1 reference

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8 April 2020

Daniela Curti

6

1 reference

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8 April 2020

Fabrizio Giordanetto

7

1 reference

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8 April 2020

Alessio Malacrida

8

1 reference

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8 April 2020

Arianna Scuteri

9

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8 April 2020

publication date

27 October 2017

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Future Medicinal Chemistry

8 April 2020

published in

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8 April 2020

volume

9

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8 April 2020

issue

17

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8 April 2020

page(s)

2029-2051

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Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis

8 April 2020

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A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for ( )-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain

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Rat liver and kidney contain high densities of sigma 1 and sigma 2 receptors: characterization by ligand binding and photoaffinity labeling.

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The mysteries of sigma receptors: new family members reveal a role in cholesterol synthesis

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21 January 2018

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21 January 2018

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21 January 2018

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sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine affords neuroprotection from focal ischemia with prolonged reperfusion

21 January 2018

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Neuroprotective effect of sigma(1)-receptor ligand 4-phenyl-1-(4-phenylbutyl) piperidine (PPBP) is linked to reduced neuronal nitric oxide production

21 January 2018

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Nerve growth factor-induced neurite sprouting in PC12 cells involves sigma-1 receptors: implications for antidepressants

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Distinct modulatory roles of sigma receptor subtypes on glutamatergic responses in the dorsal hippocampus

21 January 2018

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Involvement of dopamine (DA)/serotonin (5-HT)/sigma (sigma) receptor modulation in mediating the antidepressant action of ropinirole hydrochloride, a D2/D3 dopamine receptor agonist

21 January 2018

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Sigma receptors as potential therapeutic targets for neuroprotection

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The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements

21 January 2018

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Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc(-), the Na( )-independent glutamate-cystine exchanger

21 January 2018

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Sigma-1R agonist improves motor function and motoneuron survival in ALS mice

21 January 2018

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MAM: more than just a housekeeper

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Intracellular Dynamics of σ-1 Receptors (σ1Binding Sites) in NG108-15 Cells

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Protein kinase C-dependent potentiation of intracellular calcium influx by sigma1 receptor agonists in rat hippocampal neurons.

21 January 2018

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Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction

21 January 2018

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Physiological and pathological functions of acid-sensing ion channels in the central nervous system.

21 January 2018

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sigma-1 receptor modulation of acid-sensing ion channel a (ASIC1a) and ASIC1a-induced Ca2 influx in rat cortical neurons

21 January 2018

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Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors

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NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation in the rat hippocampus.

21 January 2018

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NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

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Haloperidol induces neurotoxicity by the NMDA receptor downstream signaling pathway, alternative from glutamate excitotoxicity.

21 January 2018

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The sigma-1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus.

21 January 2018

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Membrane-delimited coupling between sigma receptors and K channels in rat neurohypophysial terminals requires neither G-protein nor ATP

21 January 2018

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Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

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Glutathione pathways in the brain.

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Mechanism of oxidative stress in neurodegeneration

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The Role of Oxidative Stress in Neurodegenerative Diseases

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Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells

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Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival

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Conversion of psychological stress into cellular stress response: roles of the sigma-1 receptor in the process

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The transcription factor X-box binding protein-1 in neurodegenerative diseases

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Targeting the IRE1α-XBP1 branch of the unfolded protein response in human diseases

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Preventing oxidative stress: a new role for XBP1.

21 January 2018

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Reduced IRE1α mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor.

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XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

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Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

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The ER stress factor XBP1s prevents amyloid-beta neurotoxicity

21 January 2018

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Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice

21 January 2018

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The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus

21 January 2018

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Protective effect against Parkinson's disease-related insults through the activation of XBP1

21 January 2018

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The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death

21 January 2018

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Effectiveness of PSD95 inhibitors in permanent and transient focal ischemia in the rat.

21 January 2018

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Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions

21 January 2018

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Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons

21 January 2018

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Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation

21 January 2018

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Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-κB pathway.

21 January 2018

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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases

21 January 2018

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Mitochondria, oxidative stress and neurodegeneration.

21 January 2018

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Mitochondrial dysfunction in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

Mitochondrial fusion and fission in cell life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

Mitochondrial diseases of the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

3HBHDP as a novel and selective ligand for σ1 receptors in liver mitochondria and brain synaptosomes of the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

Protection of cellular and mitochondrial functions against liver ischemia by N-benzyl-N'-(2-hydroxy-3,4-dimethoxybenzyl)-piperazine (BHDP), a sigma1 ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

Sigma Receptor 1 Modulates Endoplasmic Reticulum Stress in Retinal Neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

Afobazole activation of σ-1 receptors modulates neuronal responses to amyloid-β25-35.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

Microglial activation and its implications in the brain diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

Microglia and neuroinflammation: a pathological perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

Sigma receptor ligand, ( )-pentazocine, suppresses inflammatory responses of retinal microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

The potential role of sigma-1 receptors in lipid transport and lipid raft reconstitution in the brain: implication for drug abuse

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

High-affinity σ1 protein agonist reduces clinical and pathological signs of experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

Dextromethorphan/quinidine sulfate for pseudobulbar affect

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

The pharmacology of sigma-1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents

21 January 2018

1 reference

https://api.crossref.org/works/10.4155/FMC-2017-0122

21 January 2018

Identifiers

DOI

10.4155/FMC-2017-0122

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29076758 AND SRC:MED&resulttype=core&format=json

8 April 2020

1 reference