Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment. (Q47562583)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29251920 AND SRC:MED&resulttype=core&format=json

7 April 2020

review article

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title

Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29251920 AND SRC:MED&resulttype=core&format=json

7 April 2020

main subject

multiple drug resistance

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29251920 AND SRC:MED&resulttype=core&format=json

7 April 2020

author name string

Deepali Waghray

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29251920 AND SRC:MED&resulttype=core&format=json

7 April 2020

language of work or name

English

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publication date

28 December 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29251920 AND SRC:MED&resulttype=core&format=json

Journal of Medicinal Chemistry

7 April 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29251920 AND SRC:MED&resulttype=core&format=json

7 April 2020

volume

61

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29251920 AND SRC:MED&resulttype=core&format=json

7 April 2020

issue

12

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29251920 AND SRC:MED&resulttype=core&format=json

7 April 2020

page(s)

5108-5121

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29251920 AND SRC:MED&resulttype=core&format=json

Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein

7 April 2020

cites work

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12 December 2020

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

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12 December 2020

Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction

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12 December 2020

Expression of a multidrug-resistance gene in human tumors and tissues

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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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12 December 2020

Tumor heterogeneity and drug resistance

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RS-33295-198: a novel, potent modulator of P-glycoprotein-mediated multidrug resistance

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Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen

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Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

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12 December 2020

Biochemistry of multidrug resistance mediated by the multidrug transporter

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12 December 2020

Dendroamides, new cyclic hexapeptides from a blue-green alga. Multidrug-resistance reversing activity of dendroamide A.

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12 December 2020

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

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12 December 2020

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

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12 December 2020

Positively Cooperative Sites for Drug Transport by P‐Glycoprotein with Distinct Drug Specificities

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12 December 2020

Vinflunine (20',20'-difluoro-3',4'-dihydrovinorelbine), a novel Vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro

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12 December 2020

Tenuecyclamides A-D, cyclic hexapeptides from the cyanobacterium Nostoc spongiaeforme var. tenue

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12 December 2020

A multidrug resistance transporter from human MCF-7 breast cancer cells

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12 December 2020

New cyclic peptides from the ascidian Lissoclinum patella

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12 December 2020

Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.

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12 December 2020

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

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12 December 2020

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

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12 December 2020

The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein

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12 December 2020

Determining the structure and mechanism of the human multidrug resistance P-glycoprotein using cysteine-scanning mutagenesis and thiol-modification techniques

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12 December 2020

Epothilones and related structures--a new class of microtubule inhibitors with potent in vivo antitumor activity

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12 December 2020

Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump

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12 December 2020

Calicheamicin-conjugated humanized anti-CD33 monoclonal antibody (gemtuzumab zogamicin, CMA-676) shows cytocidal effect on CD33-positive leukemia cell lines, but is inactive on P-glycoprotein-expressing sublines.

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12 December 2020

Communication between multiple drug binding sites on P-glycoprotein

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12 December 2020

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters

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12 December 2020

Antitumour activity of novel taxanes that act at the same time as cytotoxic agents and P-glycoprotein inhibitors

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12 December 2020

BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy

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12 December 2020

Multidrug-resistance phenotype and clinical responses to gemtuzumab ozogamicin

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12 December 2020

Effects of orally active taxanes on P-glycoprotein modulation and colon and breast carcinoma drug resistance

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12 December 2020

Benefit of cyclosporine modulation of drug resistance in patients with poor-risk acute myeloid leukemia: a Southwest Oncology Group study

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12 December 2020

Intraarterial chemotherapy with polyoxyethylated castor oil free paclitaxel, incorporated in albumin nanoparticles (ABI-007): Phase I study of patients with squamous cell carcinoma of the head and neck and anal canal: preliminary evidence of clinica

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12 December 2020

Multidrug resistance in cancer: role of ATP-dependent transporters

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12 December 2020

Antibody-targeted chemotherapy of older patients with acute myeloid leukemia in first relapse using Mylotarg (gemtuzumab ozogamicin).

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12 December 2020

Bistratamides E-J, modified cyclic hexapeptides from the Philippines ascidian Lissoclinum bistratum.

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12 December 2020

The biology and medicinal chemistry of epothilones

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12 December 2020

The Role of ABC Transporters in Clinical Practice

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12 December 2020

P-glycoprotein and Mrp1 collectively protect the bone marrow from vincristine-induced toxicity in vivo.

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12 December 2020

Phase I dose escalation and pharmacokinetic study of pluronic polymer-bound doxorubicin (SP1049C) in patients with advanced cancer

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12 December 2020

Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells

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12 December 2020

Paclitaxel poliglumex (XYOTAX; CT-2103): an intracellularly targeted taxane.

1 reference

12 December 2020

Cancer nanotechnology: opportunities and challenges

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12 December 2020

Tumour stem cells and drug resistance

1 reference

12 December 2020

Polymer-drug conjugates: towards a novel approach for the treatment of endrocine-related cancer.

1 reference

12 December 2020

Overcoming methotrexate resistance in breast cancer tumour cells by the use of a new cell-penetrating peptide

1 reference

12 December 2020

The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein research

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12 December 2020

Targeting multidrug resistance in cancer

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12 December 2020

The remarkable transport mechanism of P-glycoprotein: a multidrug transporter

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12 December 2020

A new polymer-lipid hybrid nanoparticle system increases cytotoxicity of doxorubicin against multidrug-resistant human breast cancer cells

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12 December 2020

A new generation of anticancer, drug-loaded, colloidal vectors reverses multidrug resistance in glioma and reduces tumor progression in rats.

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12 December 2020

Structure of a bacterial multidrug ABC transporter

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12 December 2020

Polymer therapeutics--polymers as drugs, drug and protein conjugates and gene delivery systems: past, present and future opportunities

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12 December 2020

Taxoids: cancer-fighting compounds from nature

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12 December 2020

Nanoparticles in medicine: therapeutic applications and developments

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12 December 2020

Flexibility in the ABC transporter MsbA: Alternating access with a twist

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12 December 2020

Relationship between drugs and functional activity of various mammalian P-glycoproteins (ABCB1).

1 reference

12 December 2020

Preclinical discovery of ixabepilone, a highly active antineoplastic agent

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12 December 2020

Nanocarriers as an emerging platform for cancer therapy

1 reference

12 December 2020

Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters

1 reference

12 December 2020

Synthesis and SAR of vinca alkaloid analogues

1 reference

12 December 2020

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

1 reference

12 December 2020

Structure of a multidrug transporter

1 reference

12 December 2020

Albumin-bound formulation of paclitaxel (Abraxane ABI-007) in the treatment of breast cancer

1 reference

12 December 2020

P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients

1 reference

12 December 2020

ABC efflux pump-based resistance to chemotherapy drugs.

1 reference

12 December 2020

Cytotoxicity, intracellular distribution and uptake of doxorubicin and doxorubicin coupled to cell-penetrating peptides in different cell lines: a comparative study

1 reference

12 December 2020

Mechanisms of multidrug resistance in cancer

1 reference

12 December 2020

A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction

1 reference

12 December 2020

Membrane transporters in drug development

1 reference

12 December 2020

Antibody-maytansinoid conjugates designed to bypass multidrug resistance

1 reference

12 December 2020

Cabazitaxel, a new taxane with favorable properties

1 reference

12 December 2020

Overcoming tumor multidrug resistance using drugs able to evade P-glycoprotein or to exploit its expression

1 reference

12 December 2020

Design and synthesis of Selenazole-containing peptides for cocrystallization with P-glycoprotein.

1 reference

12 December 2020

P-glycoprotein inhibition: the past, the present and the future.

1 reference

12 December 2020

Ixabepilone as Monotherapy or in Combination with Capecitabine for the Treatment of Advanced Breast Cancer

1 reference

12 December 2020

Recent attempts at RNAi‐mediated P‐glycoprotein downregulation for reversal of multidrug resistance in cancer

1 reference

12 December 2020

Polymer therapeutics as nanomedicines: new perspectives

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12 December 2020

A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris

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12 December 2020

The P-glycoprotein multidrug transporter.

1 reference

12 December 2020

Drug resistance: still a daunting challenge to the successful treatment of AML.

1 reference

12 December 2020

Targeting MDR in breast and lung cancer: discriminating its potential importance from the failure of drug resistance reversal studies.

1 reference

12 December 2020

Taxol-oligoarginine conjugates overcome drug resistance in-vitro in human ovarian carcinoma

1 reference

12 December 2020

The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely together

1 reference

12 December 2020

The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2).

1 reference

12 December 2020

Crystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegans

1 reference

12 December 2020

Intratumor heterogeneity: evolution through space and time

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12 December 2020

Fifteen years of cell-penetrating, guanidinium-rich molecular transporters: basic science, research tools, and clinical applications

1 reference

12 December 2020

Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain

1 reference

12 December 2020

Effect of doxorubicin/pluronic SP1049C on tumorigenicity, aggressiveness, DNA methylation and stem cell markers in murine leukemia

1 reference

12 December 2020

Cancer drug resistance: an evolving paradigm

1 reference

12 December 2020

P-glycoprotein ABCB1: a major player in drug handling by mammals

1 reference

12 December 2020

Refined structures of mouse P-glycoprotein

1 reference

12 December 2020

Potent Vinblastine C20' Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line

1 reference

12 December 2020

Antibody-drug conjugates: current status and future directions

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12 December 2020

Cabazitaxel: A novel taxane for metastatic castration-resistant prostate cancer-current implications and future prospects

1 reference

12 December 2020

Reversible dimers of the atypical antipsychotic quetiapine inhibit p-glycoprotein-mediated efflux in vitro with increased binding affinity and in situ at the blood-brain barrier.

1 reference

12 December 2020

Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function

1 reference

12 December 2020

A reciprocating twin-channel model for ABC transporters.

1 reference

12 December 2020

Cell-penetrating, guanidinium-rich molecular transporters for overcoming efflux-mediated multidrug resistance

1 reference

12 December 2020

Mechanisms of resistance to cabazitaxel.

1 reference

12 December 2020

Tariquidar inhibits P-glycoprotein drug efflux but activates ATPase activity by blocking transition to an open conformation

1 reference

12 December 2020

Total synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure-function properties

1 reference

12 December 2020

Distinct conformational spectrum of homologous multidrug ABC transporters

1 reference

12 December 2020

Recent advances in the development of new auristatins: structural modifications and application in antibody drug conjugates

1 reference

12 December 2020

Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein

1 reference

12 December 2020

CD30 Downregulation, MMAE Resistance, and MDR1 Upregulation Are All Associated with Resistance to Brentuximab Vedotin

1 reference

12 December 2020

Advances and Challenges of Liposome Assisted Drug Delivery

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12 December 2020

Tariquidar Is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein.

1 reference

12 December 2020

Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1).

1 reference

12 December 2020

Cell-Penetrating, Guanidinium-Rich Oligophosphoesters: Effective and Versatile Molecular Transporters for Drug and Probe Delivery

1 reference

12 December 2020

Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle.

1 reference

12 December 2020

Applications of nanoparticle drug delivery systems for the reversal of multidrug resistance in cancer.

1 reference

12 December 2020

Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface

1 reference

12 December 2020

Cancer nanomedicine: progress, challenges and opportunities

1 reference

12 December 2020

Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity

1 reference

12 December 2020

Vinflunine in the treatment of advanced urothelial cancer: clinical evidence and experience

1 reference

12 December 2020

Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1.

1 reference

12 December 2020

Dual Modulation of Human P-Glycoprotein and ABCG2 with Prodrug Dimers of the Atypical Antipsychotic Agent Paliperidone in a Model of the Blood-Brain Barrier

1 reference

12 December 2020

Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein

1 reference

12 December 2020

Structure of the human multidrug transporter ABCG2.

1 reference

12 December 2020

Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance

1 reference

12 December 2020

10.1021/ACS.JMEDCHEM.7B01457

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29251920 AND SRC:MED&resulttype=core&format=json

7 April 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29251920 AND SRC:MED&resulttype=core&format=json

7 April 2020

PubMed publication ID

29251920

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