Glymphatic clearance controls state-dependent changes in brain lactate concentration (Q47402970)

20 June 2018

title

Glymphatic clearance controls state-dependent changes in brain lactate concentration (English)

1 reference

20 June 2018

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8

Maiken Nedergaard

1 reference

20 June 2018

1

Iben Lundgaard

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20 June 2018

author name string

Minh Lon Lu

2

1 reference

20 June 2018

Ezra Yang

3

1 reference

20 June 2018

Weiguo Peng

4

1 reference

20 June 2018

Humberto Mestre

5

1 reference

20 June 2018

Emi Hitomi

6

1 reference

20 June 2018

Rashid Deane

7

1 reference

20 June 2018

publication date

1 January 2016

1 reference

20 June 2018

Journal of Cerebral Blood Flow & Metabolism

published in

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20 June 2018

volume

37

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20 June 2018

issue

6

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20 June 2018

page(s)

2112-2124

1 reference

20 June 2018

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons.

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Is L-lactate a novel signaling molecule in the brain?

22 June 2018

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Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

22 June 2018

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Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system

22 June 2018

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22 June 2018

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Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons

22 June 2018

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22 June 2018

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In vivo imaging of lymphatic drainage of cerebrospinal fluid in mouse

22 June 2018

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Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain

22 June 2018

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Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina

22 June 2018

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Sleep drives metabolite clearance from the adult brain

22 June 2018

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Regional registration of [6-(14)C]glucose metabolism during brain activation of α-syntrophin knockout mice

22 June 2018

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Substrate competition studies demonstrate oxidative metabolism of glucose, glutamate, glutamine, lactate and 3-hydroxybutyrate in cortical astrocytes from rat brain

22 June 2018

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Lactate as a biomarker for sleep

22 June 2018

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A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

22 June 2018

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Sleep slow-wave activity regulates cerebral glycolytic metabolism

22 June 2018

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Extracellular levels of lactate, but not oxygen, reflect sleep homeostasis in the rat cerebral cortex

22 June 2018

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Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory

22 June 2018

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Rapid assessment of sleep-wake behavior in mice

22 June 2018

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Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation

22 June 2018

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Critical role of aquaporin-4 (AQP4) in astrocytic Ca2 signaling events elicited by cerebral edema

22 June 2018

1 reference

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Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464705

Trafficking of glucose, lactate, and amyloid-beta from the inferior colliculus through perivascular routes

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464705

Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle

22 June 2018

1 reference

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Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons

22 June 2018

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Robust glycogen shunt activity in astrocytes: Effects of glutamatergic and adrenergic agents

22 June 2018

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Novel method for high-throughput phenotyping of sleep in mice.

22 June 2018

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THE NITROUS OXIDE METHOD FOR THE QUANTITATIVE DETERMINATION OF CEREBRAL BLOOD FLOW IN MAN: THEORY, PROCEDURE AND NORMAL VALUES.

22 June 2018

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In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space

22 June 2018

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Cortical spreading depression activates and upregulates MMP-9.

22 June 2018

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Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brain

22 June 2018

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Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle

22 June 2018

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Metabolism of [U-13C5] glutamine in cultured astrocytes studied by NMR spectroscopy: first evidence of astrocytic pyruvate recycling

22 June 2018

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Changes in brain glycogen during slow-wave sleep in the rat.

22 June 2018

1 reference

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Correlation between ventilation and brain blood flow during sleep

22 June 2018

1 reference

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Change in the Concentration of Lactic Acid in the Rat and Hamster Brain during Natural Sleep

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464705

Patterns of lymphatic drainage in the adult laboratory rat

22 June 2018

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Pitfalls in the use of rapid freezing for stopping brain and spinal cord metabolism in rat and mouse

22 June 2018

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Metabolism of brain during sleep and wakefulness

22 June 2018

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The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver

22 June 2018

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Effect of AlCl3 and other acids on cerebrospinal fluid production: a correction

22 June 2018

1 reference

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Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects

22 June 2018

1 reference

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Nonoxidative glucose consumption during focal physiologic neural activity

22 June 2018

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22 June 2018

1 reference

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Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation

22 June 2018

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Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 31P magnetic resonance spectroscopy

22 June 2018

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Lactate and pH change in close correlation in the extracellular space of the rat brain during cortical spreading depression

22 June 2018

1 reference

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Mental stress and cognitive performance do not increase overall level of cerebral O2 uptake in humans

22 June 2018

1 reference

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MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain.

22 June 2018

1 reference

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Glutamate metabolism in the brain focusing on astrocytes.

14 August 2018

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Lactate-mediated glia-neuronal signalling in the mammalian brain

14 August 2018

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Lactate receptor sites link neurotransmission, neurovascular coupling, and brain energy metabolism

14 August 2018

1 reference

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Lactate levels in the brain are elevated upon exposure to volatile anesthetics: a microdialysis study

14 August 2018

1 reference

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apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

14 August 2018

1 reference

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Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep

14 August 2018

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Isoflurane preconditioning uncouples mitochondria and protects against hypoxia-reoxygenation

14 August 2018

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Anatomy and nomenclature of murine lymph nodes: Descriptive study and nomenclatory standardization in BALB/cAnNCrl mice

14 August 2018

1 reference

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Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

14 August 2018

1 reference

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Locus ceruleus control of slow-wave homeostasis.

14 August 2018

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Locus ceruleus control of state-dependent gene expression.

14 August 2018

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THE GLUCOSE CONTENT OF BRAIN IN ANAESTHESIA

14 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464705

Demonstration of pyruvate recycling in primary cultures of neocortical astrocytes but not in neurons

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464705

Lactate in the brain of the freely moving rat: voltammetric monitoring of the changes related to the sleep-wake states

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464705

Glycolysis in neurons, not astrocytes, delays oxidative metabolism of human visual cortex during sustained checkerboard stimulation in vivo

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464705

Extracellular levels of glucose and lactate measured by quantitative microdialysis in the human brain

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464705

The Kety-Schmidt technique for repeated measurements of global cerebral blood flow and metabolism in the conscious rat.

14 August 2018

1 reference

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Cerebral oxygen/glucose ratio is low during sensory stimulation and rises above normal during recovery: excess glucose consumption during stimulation is not accounted for by lactate efflux from or accumulation in brain tissue

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464705

Rapid efflux of lactate from cerebral cortex during K -induced spreading cortical depression

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464705

Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464705

Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the Kety-Schmidt technique

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464705

Local cerebral glucose utilization in non-rapid eye movement sleep

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5464705

Factors influencing exit of substances from cerebrospinal fluid into deep cervical lymph of the rabbit

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27481936

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Increased cortical oxidative metabolism due to sensory stimulation: implications for functional brain imaging

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27481936

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1177/0271678X16661202

1 reference

20 June 2018

PMC publication ID

5464705

1 reference

20 June 2018

PubMed publication ID

27481936

1 reference

20 June 2018