BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation (Q47396558)

15 January 2018

title

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation (English)

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15 January 2018

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33

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Andreas Trumpp

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Mattia Falcone

Mattia Falcone

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Jenny Hansson

Jenny Hansson

4

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Gerhard Ehninger

26

Gerhard Ehninger

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27

Peter Lichter

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Christian Thiede

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Christian Thiede

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Jeroen Krijgsveld

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Jeroen Krijgsveld

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Lars Bullinger

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Lars Bullinger

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Simon Raffel

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Simon Raffel

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Niclas Kneisel

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Niclas Kneisel

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Gernot Poschet

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Gernot Poschet

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Yannic Nonnenmacher

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Yannic Nonnenmacher

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Andrea Barnert

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Andrea Barnert

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Carsten Bahr

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Carsten Bahr

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Petra Zeisberger

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Petra Zeisberger

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Adriana Przybylla

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Adriana Przybylla

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Martje Tönjes

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Martje Tönjes

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Lital Adler

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Lital Adler

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Patrizia Jensen

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Patrizia Jensen

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Claudia Scholl

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Claudia Scholl

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Sibylle Cocciardi

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Sibylle Cocciardi

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Patrick Wuchter

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Patrick Wuchter

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Anne Flörcken

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Anne Flörcken

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Karsten Hiller

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Karsten Hiller

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Rüdiger Hell

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Rüdiger Hell

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author name string

Wei Wang

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Christoph Lutz

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Markus Sohn

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Ayelet Erez

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Stefan Fröhling

20

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Jörg Westermann

25

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Carl Herrmann

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Anthony D Ho

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15 January 2018

language of work or name

English

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publication date

8 November 2017

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15 January 2018

published in

Nature

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15 January 2018

volume

551

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issue

7680

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15 January 2018

page(s)

384-388

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15 January 2018

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1.

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BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism.

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BCAT1, a key prognostic predictor of hepatocellular carcinoma, promotes cell proliferation and induces chemoresistance to cisplatin.

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The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer

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Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

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Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

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Expanding chemical biology of 2-oxoglutarate oxygenases

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Influence of metabolism on epigenetics and disease

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

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Stem cell gene expression programs influence clinical outcome in human leukemia.

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A 17-gene stemness score for rapid determination of risk in acute leukaemia

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Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice

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Detection, isolation, and stimulation of quiescent primitive leukemic progenitor cells from patients with acute myeloid leukemia (AML).

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Transaminase of branched chain amino acids. I. Branched chain amino acids-alpha-ketoglutarate transaminase.

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Pyrimidine Nucleotide Biosynthesis in Animals: Genes, Enzymes, and Regulation of UMP Biosynthesis

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Targeting HIF1α eliminates cancer stem cells in hematological malignancies.

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

21 January 2018

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IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication

21 January 2018

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Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

21 January 2018

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Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome

21 January 2018

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Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

21 January 2018

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

21 January 2018

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α-Ketoglutarate Accelerates the Initial Differentiation of Primed Human Pluripotent Stem Cells

21 January 2018

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Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells

21 January 2018

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Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics

21 January 2018

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Bioconductor: open software development for computational biology and bioinformatics

21 January 2018

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Linear models and empirical bayes methods for assessing differential expression in microarray experiments

21 January 2018

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A multicolor panel of novel lentiviral "gene ontology" (LeGO) vectors for functional gene analysis.

21 January 2018

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MetaboliteDetector: comprehensive analysis tool for targeted and nontargeted GC/MS based metabolome analysis

21 January 2018

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Intracellular nucleotide and nucleotide sugar contents of cultured CHO cells determined by a fast, sensitive, and high-resolution ion-pair RP-HPLC.

21 January 2018

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A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids

21 January 2018

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Comprehensive analysis of DNA methylation data with RnBeads

21 January 2018

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A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data

21 January 2018

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Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia.

21 January 2018

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Branched-chain [corrected] amino acid metabolism: implications for establishing safe intakes

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE24294

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15 January 2018

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15 January 2018