Combining in vitro and in silico approaches to find new drugs targeting the pathological proteins related to the Alzheimer's disease (Q47396500)

15 January 2018

http://europepmc.org/abstract/MED/29086699

4 references

25 April 2019

20 June 2019

19 September 2019

25 January 2021

Combining in vitro and in silico approaches to find new drugs targeting the pathological proteins related to the Alzheimer's disease (English)

1 reference

15 January 2018

http://europepmc.org/abstract/MED/29086699

3 references

25 April 2019

20 June 2019

19 September 2019

biomedical investigative technique

1 reference

19 September 2019

1 reference

25 January 2021

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29086699 AND SRC:MED&resulttype=core&format=json

6 June 2020

Zhaogang Yang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29086699 AND SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Hui Li

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29086699 AND SRC:MED&resulttype=core&format=json

6 June 2020

Xiaobing Wang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29086699 AND SRC:MED&resulttype=core&format=json

6 June 2020

Hongmei Yu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29086699 AND SRC:MED&resulttype=core&format=json

6 June 2020

Hongtao Jin

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29086699 AND SRC:MED&resulttype=core&format=json

6 June 2020

Aiping Wang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29086699 AND SRC:MED&resulttype=core&format=json

6 June 2020

language of work or name

1 reference

30 October 2017

1 reference

15 January 2018

http://europepmc.org/abstract/MED/29086699

published in

Current Neuropharmacology

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29086699 AND SRC:MED&resulttype=core&format=json

6 June 2020

25 January 2021

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29086699 AND SRC:MED&resulttype=core&format=json

6 June 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29086699 AND SRC:MED&resulttype=core&format=json

6 June 2020

page(s)

758-768

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29086699 AND SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial

6 June 2020

copyright license

4 references

25 April 2019

20 June 2019

19 September 2019

25 January 2021

on focus list of Wikimedia project

ScienceSource

0 references

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One for All? Hitting Multiple Alzheimer's Disease Targets with One Drug

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1 December 2018

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1 December 2018

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1 December 2018

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Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis

1 December 2018

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In silico pharmacology: drug design and discovery's gate to the future

1 December 2018

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1 December 2018

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Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

1 December 2018

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BACE1 Inhibitor Peptides: Can an Infinitely Small k cat Value Turn the Substrate of an Enzyme into Its Inhibitor?

1 December 2018

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1 December 2018

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The intersection of amyloid beta and tau at synapses in Alzheimer's disease

1 December 2018

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1 December 2018

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1 December 2018

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1 December 2018

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A lifespan observation of a novel mouse model: in vivo evidence supports aβ oligomer hypothesis

1 December 2018

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Understanding amyloid fibril nucleation and aβ oligomer/drug interactions from computer simulations

1 December 2018

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Alzheimer disease therapy--moving from amyloid-β to tau.

1 December 2018

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Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes

1 December 2018

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1 December 2018

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Comprehensive 3D-QSAR and binding mode of BACE-1 inhibitors using R-group search and molecular docking

1 December 2018

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1 December 2018

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1 December 2018

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1 December 2018

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Bapineuzumab and solanezumab for Alzheimer's disease: is the 'amyloid cascade hypothesis' still alive?

1 December 2018

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Molecular mechanism of the inhibition of EGCG on the Alzheimer Aβ(1-42) dimer.

1 December 2018

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Correlation of specific amyloid-β oligomers with tau in cerebrospinal fluid from cognitively normal older adults

1 December 2018

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Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design.

1 December 2018

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Drug repositioning by structure-based virtual screening

1 December 2018

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LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.

1 December 2018

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Tau as a therapeutic target in neurodegenerative disease

1 December 2018

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Immunotherapy for Alzheimer disease: the challenge of adverse effects.

1 December 2018

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Solanezumab for the treatment of mild-to-moderate Alzheimer's disease

1 December 2018

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Cholinesterases, a target of pharmacology and toxicology

1 December 2018

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The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

1 December 2018

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Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease.

1 December 2018

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In silico modeling systems: Learning about the prevalence and dynamics of dementia through virtual experimentation

1 December 2018

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Potent BACE-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies

1 December 2018

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Novel insights for the treatment of Alzheimer's disease

1 December 2018

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Alzheimer's disease: strategies for disease modification

1 December 2018

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A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

1 December 2018

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Elucidation of amyloid beta-protein oligomerization mechanisms: discrete molecular dynamics study.

1 December 2018

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In silico prediction and screening of gamma-secretase inhibitors by molecular descriptors and machine learning methods.

1 December 2018

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Novel opportunities for computational biology and sociology in drug discovery.

1 December 2018

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The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

1 December 2018

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Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases

1 December 2018

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Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

1 December 2018

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From virtuality to reality - Virtual screening in lead discovery and lead optimization: a medicinal chemistry perspective

1 December 2018

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 December 2018

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Current and future therapy in Alzheimer's disease.

1 December 2018

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Computational study on the structural diversity of amyloid Beta Peptide (abeta(10-35)) oligomers.

1 December 2018

1 reference

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Presenilin: running with scissors in the membrane

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

Active gamma-secretase complexes contain only one of each component

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

Intracerebroventricular passive immunization with anti-oligoAbeta antibody in TgCRND8.

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

A century of Alzheimer's disease

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

In silico discovery of beta-secretase inhibitors

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

Efficacy and safety of memantine in moderate-to-severe Alzheimer disease: the evidence to date

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

Current pharmacotherapy for Alzheimer's disease

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

Virtual screening of chemical libraries

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

Lifelong immunization with human beta-amyloid (1-42) protects Alzheimer's transgenic mice against cognitive impairment throughout aging

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

In silico approaches for predicting ADME properties of drugs

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

Virtual screening in lead discovery and optimization.

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

The case described by Alois Alzheimer in 1911. Historical and conceptual perspectives based on the clinical record and neurohistological sections

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

Computational methods for biomolecular docking.

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6080099

In silico biology: more than computer games

1 December 2018

1 reference

12 December 2020

Amyloid beta-peptide oligomerization in silico: dimer and trimer

1 reference

12 December 2020

Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion

1 reference

12 December 2020

Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design

1 reference

12 December 2020

10.2174/1570159X15666171030142108

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29086699 AND SRC:MED&resulttype=core&format=json

6 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29086699 AND SRC:MED&resulttype=core&format=json

6 June 2020

1 reference