Structure-activity studies of peptidomimetics based on kinase-inhibitory region of suppressors of cytokine signaling 1. (Q47386577)

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3 April 2020

title

Structure-activity studies of peptidomimetics based on kinase-inhibitory region of suppressors of cytokine signaling 1 (English)

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3 April 2020

author name string

Sara La Manna

1

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3 April 2020

Laura Lopez-Sanz

2

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3 April 2020

Marilisa Leone

3

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3 April 2020

Paola Brandi

4

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3 April 2020

Pasqualina Liana Scognamiglio

5

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3 April 2020

Giancarlo Morelli

6

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3 April 2020

Carmen Gomez-Guerrero

8

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3 April 2020

publication date

20 November 2017

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3 April 2020

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The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response

3 April 2020

cites work

1 reference

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Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT

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Gene delivery of suppressors of cytokine signaling (SOCS) inhibits inflammation and atherosclerosis development in mice

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Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

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A three-dimensional model of Suppressor Of Cytokine Signalling 1 (SOCS-1).

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The N-terminal domains of SOCS proteins: a conserved region in the disordered N-termini of SOCS4 and 5.

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Intrinsically disordered proteins and multicellular organisms

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The kinase inhibitory region of SOCS-1 is sufficient to inhibit T-helper 17 and other immune functions in experimental allergic encephalomyelitis

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Treatment of mice with the suppressor of cytokine signaling-1 mimetic peptide, tyrosine kinase inhibitor peptide, prevents development of the acute form of experimental allergic encephalomyelitis and induces stable remission in the chronic relapsing

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Both the suppressor of cytokine signaling 1 (SOCS-1) kinase inhibitory region and SOCS-1 mimetic bind to JAK2 autophosphorylation site: implications for the development of a SOCS-1 antagonist

21 January 2018

1 reference

Characterization of a peptide inhibitor of Janus kinase 2 that mimics suppressor of cytokine signaling 1 function

21 January 2018

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SOCS-1 mimetics protect mice against lethal poxvirus infection: identification of a novel endogenous antiviral system

21 January 2018

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Suppressor of Cytokine Signaling-1 Peptidomimetic Limits Progression of Diabetic Nephropathy.

21 January 2018

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Past and future perspectives of synthetic peptide libraries

21 January 2018

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Discovery of Small Peptide Antagonists of PED/PEA15–D4α Interaction from Simplified Combinatorial Libraries

21 January 2018

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Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses.

21 January 2018

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Species-dependent binding of new synthesized bicalutamide analogues to albumin by optical biosensor analysis

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New mimetic peptides of the kinase-inhibitory region (KIR) of SOCS1 through focused peptide libraries

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Quantitative analysis of JAK binding using isothermal titration calorimetry and surface plasmon resonance

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Vascular Smooth Muscle Cells in Atherosclerosis

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Evolutionary screening and adsorption behavior of engineered M13 bacteriophage and derived dodecapeptide for selective decoration of gold interfaces.

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Overview of tyrosine kinase inhibitors in clinical breast cancer.

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Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited

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Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia.

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A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules

21 January 2018

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Suppressors of cytokine signaling and immunity

21 January 2018

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Efficient delivery of cyclic peptides into mammalian cells with short sequence motifs

21 January 2018

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PONDR-FIT: a meta-predictor of intrinsically disordered amino acids

21 January 2018

1 reference

From peptides to small molecules: an intriguing but intricated way to new drugs.

21 January 2018

1 reference

A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells.

21 January 2018

1 reference

Lead Optimization of P5U and Urantide: Discovery of Novel Potent Ligands at the Urotensin-II Receptor

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIP.23082

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29154500 AND SRC:MED&resulttype=core&format=json

3 April 2020

1 reference