Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex (Q47322329)

14 January 2018

http://europepmc.org/abstract/MED/29212816

title

Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex (English)

1 reference

14 January 2018

http://europepmc.org/abstract/MED/29212816

0 references

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

Barbara G Mlody

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

Dmytro Puchkov

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

Josef Priller

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

Alessandro Prigione

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

Janine Kirstein

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

author name string

Annika Scior

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

Alexander Buntru

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

Kristin Arnsburg

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

Anne Ast

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

Katrin Juenemann

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

Maria Lucia Pigazzini

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

Erich E Wanker

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

language of work or name

English

0 references

publication date

6 December 2017

1 reference

14 January 2018

http://europepmc.org/abstract/MED/29212816

published in

The EMBO Journal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

volume

37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

page(s)

282-299

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging.

12 June 2020

cites work

1 reference

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Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders

26 August 2018

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Cellular strategies to cope with protein aggregation

26 August 2018

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Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors

26 August 2018

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In vivo aspects of protein folding and quality control

26 August 2018

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The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.

26 August 2018

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Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils

26 August 2018

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Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

26 August 2018

1 reference

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Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments

26 August 2018

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Molecular interaction between the chaperone Hsc70 and the N-terminal flank of huntingtin exon 1 modulates aggregation

26 August 2018

1 reference

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A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease

26 August 2018

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Novel polyglutamine model uncouples proteotoxicity from aging

26 August 2018

1 reference

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Quantification assays for total and polyglutamine-expanded huntingtin proteins

26 August 2018

1 reference

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Chemical kinetics for drug discovery to combat protein aggregation diseases

26 August 2018

1 reference

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Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome

26 August 2018

1 reference

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Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro

26 August 2018

1 reference

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Suppression of polyglutamine protein toxicity by co-expression of a heat-shock protein 40 and a heat-shock protein 110

26 August 2018

1 reference

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Heat shock response activation exacerbates inclusion body formation in a cellular model of Huntington disease

26 August 2018

1 reference

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Age-associated metabolic and morphologic changes in mitochondria of individual mouse and hamster oocytes

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5770855

Hsp110 is a bona fide chaperone using ATP to unfold stable misfolded polypeptides and reciprocally collaborate with Hsp70 to solubilize protein aggregates.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5770855

The nascent polypeptide-associated complex is a key regulator of proteostasis

26 August 2018

1 reference

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Aging and the aggregating proteome

26 August 2018

1 reference

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Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

26 August 2018

1 reference

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Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes

26 August 2018

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Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease

26 August 2018

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Physical chemistry of polyglutamine: intriguing tales of a monotonous sequence

26 August 2018

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Neuronal degeneration in striatal transplants and Huntington's disease: potential mechanisms and clinical implications.

26 August 2018

1 reference

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Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

26 August 2018

1 reference

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Nuclear accumulation of polyglutamine disease proteins and neuropathology

26 August 2018

1 reference

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Aggregation of expanded huntingtin in the brains of patients with Huntington disease.

26 August 2018

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Late onset Huntington Disease: clinical and genetic characteristics of 34 cases

26 August 2018

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Adapting proteostasis for disease intervention

26 August 2018

1 reference

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The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions

26 August 2018

1 reference

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Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis

26 August 2018

1 reference

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polyglutamine aggregation nucleation: thermodynamics of a highly unfavorable protein folding reaction

26 August 2018

1 reference

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Evolutionary optimization of fluorescent proteins for intracellular FRET

26 August 2018

1 reference

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The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

26 August 2018

1 reference

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Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells

26 August 2018

1 reference

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Behavioral dysfunction, brain oxidative stress, and impaired mitochondrial electron transfer in aging mice

26 August 2018

1 reference

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

26 August 2018

1 reference

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Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease

26 August 2018

1 reference

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Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.

26 August 2018

1 reference

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Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5770855

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5770855

Lysine 71 of the chaperone protein Hsc70 Is essential for ATP hydrolysis

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5770855

Characterization of nucleotide-free uncoating ATPase and its binding to ATP, ADP, and ATP analogues

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5770855

Structural basis of the 70-kilodalton heat shock cognate protein ATP hydrolytic activity. I. Kinetic analyses of active site mutants

26 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29212816

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

27 Analysis of chaperone function using citrate synthase as nonnative substrate protein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29212816

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Concerted and nonconcerted evolution of the Hsp70 gene superfamily in two sibling species of nematodes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29212816

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.15252/EMBJ.201797212

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29212816 AND SRC:MED&resulttype=core&format=json

12 June 2020

1 reference