Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) Promotes Hippocampus-Dependent Memory via Its Deubiquitinating Effect on TrkB. (Q47321547)

14 January 2018

http://europepmc.org/abstract/MED/28500221

title

Ubiquitin C-Terminal Hydrolase L1 (UCH-L1) Promotes Hippocampus-Dependent Memory via Its Deubiquitinating Effect on TrkB. (English)

1 reference

14 January 2018

http://europepmc.org/abstract/MED/28500221

author

Bo Su

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6596500&resulttype=core&format=json

15 May 2020

author name string

Yun-Yun Guo

1

1 reference

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15 May 2020

Yi Lu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6596500&resulttype=core&format=json

15 May 2020

Yuan Zheng

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6596500&resulttype=core&format=json

15 May 2020

Xiao-Rong Chen

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6596500&resulttype=core&format=json

15 May 2020

Jun-Lu Dong

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6596500&resulttype=core&format=json

15 May 2020

Rong-Rong Yuan

6

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15 May 2020

Shu-Hong Huang

7

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15 May 2020

Hui Yu

8

1 reference

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15 May 2020

Yue Wang

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6596500&resulttype=core&format=json

15 May 2020

Zhe-Yu Chen

10

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15 May 2020

language of work or name

English

0 references

publication date

12 May 2017

1 reference

14 January 2018

http://europepmc.org/abstract/MED/28500221

published in

Journal of Neuroscience

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6596500&resulttype=core&format=json

15 May 2020

volume

37

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6596500&resulttype=core&format=json

15 May 2020

issue

25

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15 May 2020

page(s)

5978-5995

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6596500&resulttype=core&format=json

Essential role for TrkB receptors in hippocampus-mediated learning

15 May 2020

cites work

1 reference

12 December 2020

Down-regulation of the neurotrophin receptor TrkB following ligand binding. Evidence for an involvement of the proteasome and differential regulation of TrkA and TrkB.

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The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

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Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

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Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron

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Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases

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p75 neurotrophin receptor reduces ligand-induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation

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A novel endocytic recycling signal distinguishes biological responses of Trk neurotrophin receptors

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Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling

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Cell Survival through Trk Neurotrophin Receptors Is Differentially Regulated by Ubiquitination

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Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory

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Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior

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Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene

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Clathrin-dependent endocytosis is required for TrkB-dependent Akt-mediated neuronal protection and dendritic growth.

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Identification of a consensus site for TRAF6/p62 polyubiquitination

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Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor

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Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

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Essential role of Hrs in endocytic recycling of full-length TrkB receptor but not its isoform TrkB.T1.

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Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1.

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Proteasomal inhibition alters the trafficking of the neurotrophin receptor TrkA.

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Direct ubiquitination of beta-catenin by Siah-1 and regulation by the exchange factor TBL1.

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Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

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Regulation of trafficking of activated TrkA is critical for NGF-mediated functions

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Region-Specific Involvement of BDNF Secretion and Synthesis in Conditioned Taste Aversion Memory Formation

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JIP3 Mediates TrkB Axonal Anterograde Transport and Enhances BDNF Signaling by Directly Bridging TrkB with Kinesin-1

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Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1.

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The role of ubiquitylation in receptor endocytosis and endosomal sorting

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Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration

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Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA.

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12 December 2020

Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity

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12 December 2020

β-Amyloid (Aβ) oligomers impair brain-derived neurotrophic factor retrograde trafficking by down-regulating ubiquitin C-terminal hydrolase, UCH-L1.

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12 December 2020

BDNF-dependent recycling facilitates TrkB translocation to postsynaptic density during LTP via a Rab11-dependent pathway.

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BH3-only proteins Noxa, Bik, Bmf, and Bid activate Bax and Bak indirectly when studied in yeast model

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TrkA in vivo function is negatively regulated by ubiquitination

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In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA

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Glucocorticoid regulates TrkB protein levels via c-Cbl dependent ubiquitination: a decrease in c-Cbl mRNA in the prefrontal cortex of suicide subjects

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The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase

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Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo

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Blocking GSK3β-mediated dynamin1 phosphorylation enhances BDNF-dependent TrkB endocytosis and the protective effects of BDNF in neuronal and mouse models of Alzheimer's disease

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12 December 2020

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.

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12 December 2020

Tyrosine kinase receptor B protects against coronary artery disease and promotes adult vasculature integrity by regulating Ets1-mediated VE-cadherin expression

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12 December 2020

Activity-Dependent Ubiquitination of GluA1 and GluA2 Regulates AMPA Receptor Intracellular Sorting and Degradation

1 reference

12 December 2020

Differential role of the proteasome in the early and late phases of BDNF-induced facilitation of LTP.

1 reference

12 December 2020

Kalirin is required for BDNF-TrkB stimulated neurite outgrowth and branching

1 reference

12 December 2020

Deletion of a conserved juxtamembrane sequence in Trk abolishes NGF-promoted neuritogenesis

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12 December 2020

Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues

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12 December 2020

Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia

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CREB: a major mediator of neuronal neurotrophin responses

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12 December 2020

Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases

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The ubiquitin pathway in Parkinson's disease

1 reference

12 December 2020

10.1523/JNEUROSCI.3148-16.2017

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6596500&resulttype=core&format=json

15 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6596500&resulttype=core&format=json

15 May 2020

1 reference