Melatonin inhibits nucleus pulposus (NP) cell proliferation and extracellular matrix (ECM) remodeling via the melatonin membrane receptors mediated PI3K-Akt pathway (Q47272699)

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scientific article published on 18 July 2017

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English	Melatonin inhibits nucleus pulposus (NP) cell proliferation and extracellular matrix (ECM) remodeling via the melatonin membrane receptors mediated PI3K-Akt pathway	scientific article published on 18 July 2017

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scholarly article

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Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/28719035

Melatonin inhibits nucleus pulposus (NP) cell proliferation and extracellular matrix (ECM) remodeling via the melatonin membrane receptors mediated PI3K-Akt pathway (English)

1 reference

Europe PubMed Central

PubMed publication ID

13 January 2018

http://europepmc.org/abstract/MED/28719035

extracellular matrix

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5 June 2020

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5 June 2020

William Ka-Kei Wu

5

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5 June 2020

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Zheng Li

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5 June 2020

Xingye Li

2

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publication date

18 July 2017

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13 January 2018

http://europepmc.org/abstract/MED/28719035

Journal of Pineal Research

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5 June 2020

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5 June 2020

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5 June 2020

Treatment outcome of chronic low back pain and radiographic lumbar disc degeneration are associated with inflammatory and matrix degrading gene variants: a prospective genetic association study

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Bone morphogenetic protein-7 protects human intervertebral disc cells in vitro from apoptosis

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Leptin induces cyclin D1 expression and proliferation of human nucleus pulposus cells via JAK/STAT, PI3K/Akt and MEK/ERK pathways

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The role of leptin on the organization and expression of cytoskeleton elements in nucleus pulposus cells

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Leptin activates RhoA/ROCK pathway to induce cytoskeleton remodeling in nucleus pulposus cells.

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MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervertebral disc degeneration

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Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration

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Human nucleus pulposus cells react to IL-6: independent actions and amplification of response to IL-1 and TNF-α.

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Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis

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Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke-induced chronic obstructive pulmonary diseases via the suppression of Erk-Sp1 signaling

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Melatonin attenuates neurogenic pulmonary edema via the regulation of inflammation and apoptosis after subarachnoid hemorrhage in rats.

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Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells

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Melatonin decreases muscular oxidative stress and inflammation induced by strenuous exercise and stimulates growth factor synthesis

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Melatonin-mediated Bim up-regulation and cyclooxygenase-2 (COX-2) down-regulation enhances tunicamycin-induced apoptosis in MDA-MB-231 cells

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Melatonin modulates the fetal cardiovascular defense response to acute hypoxia

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Placental melatonin system is present throughout pregnancy and regulates villous trophoblast differentiation

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Melatonin prevents cisplatin-induced primordial follicle loss via suppression of PTEN/AKT/FOXO3a pathway activation in the mouse ovary

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Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

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Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation.

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HDAC1 inhibition by melatonin leads to suppression of lung adenocarcinoma cells via induction of oxidative stress and activation of apoptotic pathways

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Melatonin: an ancient molecule that makes oxygen metabolically tolerable.

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Interleukin-17, oxidative stress, and inflammation: role of melatonin during Trypanosoma cruzi infection

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Melatonin significantly improves the developmental competence of bovine somatic cell nuclear transfer embryos

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Melatonin enhances the occurrence of autophagy induced by oxidative stress in Arabidopsis seedlings

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Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro

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Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice.

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Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation

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Melatonin attenuates methamphetamine-induced inhibition of proliferation of adult rat hippocampal progenitor cells in vitro

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Melatonin sensitizes human breast cancer cells to ionizing radiation by downregulating proteins involved in double-strand DNA break repair.

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Changes in vascularity of cartilage endplate of degenerated intervertebral discs in response to melatonin administration in rats

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Surgical pinealectomy accelerates intervertebral disc degeneration process in chicken

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Correlation of serum trace elements and melatonin levels to radiological, biochemical, and histological assessment of degeneration in patients with intervertebral disc herniation

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miR-613 regulates cholesterol efflux by targeting LXRα and ABCA1 in PPARγ activated THP-1 macrophages

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Melatonin rescues cardiac thioredoxin system during ischemia-reperfusion injury in acute hyperglycemic state by restoring Notch1/Hes1/Akt signaling in a membrane receptor-dependent manner.

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Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus

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Melatonin-mediated inhibition of Purkinje neuron P-type Ca²⁺ channels in vitro induces neuronal hyperexcitability through the phosphatidylinositol 3-kinase-dependent protein kinase C delta pathway

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Melatonin compensates silencing of heat shock protein 70 and suppresses ultraviolet radiation-induced inflammation in human skin ex vivo and cultured keratinocytes

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Identifiers

10.1111/JPI.12435

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28719035 AND SRC:MED&resulttype=core&format=json

5 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28719035 AND SRC:MED&resulttype=core&format=json

5 June 2020

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