Essential role for phospholipase D2 activation downstream of ERK MAP kinase in nerve growth factor-stimulated neurite outgrowth from PC12 cells. (Q47265545)

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scientific article published on 29 June 2004

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English	Essential role for phospholipase D2 activation downstream of ERK MAP kinase in nerve growth factor-stimulated neurite outgrowth from PC12 cells.	scientific article published on 29 June 2004

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30 December 2019

Essential role for phospholipase D2 activation downstream of ERK MAP kinase in nerve growth factor-stimulated neurite outgrowth from PC12 cells (English)

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30 December 2019

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Takehiko Sasaki

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30 December 2019

Tomohiko Maehama

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30 December 2019

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Hiroshi Watanabe

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30 December 2019

Takeaki Yokozeki

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30 December 2019

Masakazu Yamazaki

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30 December 2019

Hideyuki Miyazaki

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30 December 2019

Kouichi Itoh

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30 December 2019

Michael A Frohman

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30 December 2019

Yasunori Kanaho

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30 December 2019

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29 June 2004

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30 December 2019

Journal of Biological Chemistry

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30 December 2019

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30 December 2019

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30 December 2019

37870-37877

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30 December 2019

Repulsive and inhibitory signals

1 reference

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The molecular biology of axon guidance

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Rho effectors and reorganization of actin cytoskeleton

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Rho GTPases and the Actin Cytoskeleton

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Rho family GTP-binding proteins in growth cone signalling

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Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells.

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Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase

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Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells

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Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase.

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Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling.

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Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling

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Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid

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Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology

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CAMs and axonal growth: a critical evaluation of the role of calcium and the MAPK cascade

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21 January 2018

Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells.

1 reference

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21 January 2018

Characterization of two alternately spliced forms of phospholipase D1. Activation of the purified enzymes by phosphatidylinositol 4,5-bisphosphate, ADP-ribosylation factor, and Rho family monomeric GTP-binding proteins and protein kinase C-alpha

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21 January 2018

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

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Phospholipase D Stimulates Release of Nascent Secretory Vesicles from the trans-Golgi Network

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Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells

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A role for phospholipase D1 in neurotransmitter release.

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Intracellular localization of phospholipase D1 in mammalian cells

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21 January 2018

Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation

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21 January 2018

Molecular mechanisms of axon guidance

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21 January 2018

Cloning and expression analysis of murine phospholipase D1

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Localization of mRNAs for phospholipase D (PLD) type 1 and 2 in the brain of developing and mature rat.

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21 January 2018

Phospholipase D activation by norepinephrine is mediated by 12(s)-, 15(s)-, and 20-hydroxyeicosatetraenoic acids generated by stimulation of cytosolic phospholipase a2. tyrosine phosphorylation of phospholipase d2 in response to norepinephrine

1 reference

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21 January 2018

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

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21 January 2018

Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity.

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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

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21 January 2018

Phospholipase D2 functions as a downstream signaling molecule of MAP kinase pathway in L1-stimulated neurite outgrowth of cerebellar granule neurons.

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21 January 2018

Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway

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21 January 2018

Involvement of ERK and p38 MAP kinase in oxidative stress-induced phospholipase D activation in PC12 cells

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A synthetic inhibitor of the mitogen-activated protein kinase cascade

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Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles

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ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1.

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Membrane targeting of p21-activated kinase 1(PAK1) induces neurite outgrowth from PC12 cells

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Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation.

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Phospholipase D

1 reference

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Phospholipase D structure and regulation

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Phospholipase D: molecular and cell biology of a novel gene family

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Signaling to actin dynamics

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Tight binding inhibition of protein phosphatase-1 by phosphatidic acid. Specificity of inhibition by the phospholipid

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Differential binding of traffic-related proteins to phosphatidic acid- or phosphatidylinositol (4,5)- bisphosphate-coupled affinity reagents

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21 January 2018

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

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The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

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21 January 2018

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