Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease (Q47252056)

12 January 2018

http://europepmc.org/abstract/MED/29281014

title

Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington's disease. (English)

1 reference

12 January 2018

http://europepmc.org/abstract/MED/29281014

0 references

5

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1 June 2020

author name string

Wan Song

1

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1 June 2020

Nóra Zsindely

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29281014 AND SRC:MED&resulttype=core&format=json

1 June 2020

Anikó Faragó

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29281014 AND SRC:MED&resulttype=core&format=json

1 June 2020

J Lawrence Marsh

4

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1 June 2020

publication date

21 December 2017

1 reference

12 January 2018

http://europepmc.org/abstract/MED/29281014

published in

Human Molecular Genetics

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1 June 2020

volume

27

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1 June 2020

issue

4

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1 June 2020

page(s)

649-666

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describes a project that uses

1 June 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5886221/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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UTX, a Histone H3-Lysine 27 Demethylase, Acts as a Critical Switch to Activate the Cardiac Developmental Program

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase

26 August 2018

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The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase.

26 August 2018

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The role of chromatin during transcription

26 August 2018

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Chromatin modifications and their function

26 August 2018

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Histone methylation is required for oogenesis in Drosophila

26 August 2018

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26 August 2018

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26 August 2018

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The Drosophila G9a gene encodes a multi-catalytic histone methyltransferase required for normal development

26 August 2018

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The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

26 August 2018

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The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.

26 August 2018

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Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

26 August 2018

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JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

26 August 2018

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Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation

26 August 2018

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The diverse functions of histone lysine methylation

26 August 2018

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Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes

26 August 2018

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Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase

26 August 2018

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The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation

26 August 2018

1 reference

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PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis

26 August 2018

1 reference

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Genomic maps and comparative analysis of histone modifications in human and mouse

26 August 2018

1 reference

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Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila

26 August 2018

1 reference

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Regulation of p53 activity through lysine methylation

26 August 2018

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Regulated nucleosome mobility and the histone code.

26 August 2018

1 reference

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Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease

26 August 2018

1 reference

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Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase

26 August 2018

1 reference

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SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Chromatin acetylation, memory, and LTP are impaired in CBP /- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration.

26 August 2018

1 reference

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Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome.

26 August 2018

1 reference

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Can flies help humans treat neurodegenerative diseases?

26 August 2018

1 reference

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Histone H3.3 is enriched in covalent modifications associated with active chromatin

26 August 2018

1 reference

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Histone H3 lysine 4 methylation patterns in higher eukaryotic genes

26 August 2018

1 reference

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Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

An Alzheimer's disease hypothesis based on transcriptional dysregulation

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

SU(VAR)3-9 is a conserved key function in heterochromatic gene silencing.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Histone methyltransferase activity of a Drosophila Polycomb group repressor complex

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Active genes are tri-methylated at K4 of histone H3

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Establishment and maintenance of a heterochromatin domain

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Molecular genetic analysis of the Drosophila trithorax-related gene which encodes a novel SET domain protein

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Disruption of Higher-Order Folding by Core Histone Acetylation Dramatically Enhances Transcription of Nucleosomal Arrays by RNA Polymerase III

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

The Drosophila ash1 gene product, which is localized at specific sites on polytene chromosomes, contains a SET domain and a PHD finger

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Regulation, function and potential origin of the Drosophila gene spalt adjacent, which encodes a secreted protein expressed in the early embryo

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Molecular genetic analysis of the Drosophila melanogaster gene absent, small or homeotic discs1 (ash1).

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Molecular characterization of the trithorax gene, a positive regulator of homeotic gene expression in Drosophila

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5886221

Genomic structure and expression of the mouse ESET gene encoding an ERG-associated histone methyltransferase with a SET domain

26 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29281014

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDX432

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29281014 AND SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29281014 AND SRC:MED&resulttype=core&format=json

1 June 2020

1 reference