Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases. (Q47250488)

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Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases (English)

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Mélanie Roué

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Laurent Meijer

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Peter Proksch

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Michelle Klautau

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author name string

Nadège Loaëc

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Eletta Attanasio

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Benoît Villiers

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Emilie Durieu

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Tania Tahtouh

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Morgane Cam

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Aline Alencar

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Marie-Lise Bourguet-Kondracki

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Emmanuelle Limanton

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Solène Guiheneuf

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François Carreaux

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Jean-Pierre Bazureau

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publication date

17 October 2017

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Creative Commons Attribution

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Current Status of Marine-Derived Compounds as Warheads in Anti-Tumor Drug Candidates

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Drugs and Drug Candidates from Marine Sources: An Assessment of the Current "State of Play".

23 May 2018

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Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25-35 peptide administration in mice

23 May 2018

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A historical overview of protein kinases and their targeted small molecule inhibitors

23 May 2018

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DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome

23 May 2018

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23 May 2018

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Sponge grade body fossil with cellular resolution dating 60 Myr before the Cambrian

23 May 2018

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Marine natural products as inhibitors of cystathionine beta-synthase activity

23 May 2018

1 reference

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4,5-Di-substituted benzyl-imidazol-2-substituted amines as the structure template for the design and synthesis of reversal agents against P-gp-mediated multidrug resistance breast cancer cells.

23 May 2018

1 reference

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The Down syndrome-related protein kinase DYRK1A phosphorylates p27(Kip1) and Cyclin D1 and induces cell cycle exit and neuronal differentiation

23 May 2018

1 reference

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Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection

23 May 2018

1 reference

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cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.

23 May 2018

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Benzylidene 2-aminoimidazolones derivatives: synthesis and in vitro evaluation of anti-tumor carcinoma activity

23 May 2018

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2-Aminoimidazoles in medicinal chemistry

23 May 2018

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Design, synthesis and spectroscopic characterisation of a focused library based on the polyandrocarpamine natural product scaffold

23 May 2018

1 reference

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Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B

23 May 2018

1 reference

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Assessing calcareous sponges and their associated bacteria for the discovery of new bioactive natural products

23 May 2018

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Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

23 May 2018

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Structure and synthesis of 2-aminoimidazole alkaloids from Leucetta and Clathrina sponges

23 May 2018

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Cellular localization of clathridimine, an antimicrobial 2-aminoimidazole alkaloid produced by the Mediterranean calcareous sponge Clathrina clathrus

23 May 2018

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Preparation of hymenialdisine, analogues and their evaluation as kinase inhibitors

23 May 2018

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Aplysinopsins--marine indole alkaloids: chemistry, bioactivity and ecological significance

23 May 2018

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A quantitative analysis of kinase inhibitor selectivity

23 May 2018

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Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors

23 May 2018

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Conversion of phosphorylase b to phosphorylase a in muscle extracts

23 May 2018

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Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent

23 May 2018

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Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors: a survey of recent patent literature

23 May 2018

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14 August 2018

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Long-range crystalline order in spicules from the calcareous sponge Paraleucilla magna (Porifera, Calcarea).

14 August 2018

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Purification of CK1 by affinity chromatography on immobilised axin

14 August 2018

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A likely biogenetic gateway linking 2-aminoimidazolinone metabolites of sponges to proline: spontaneous oxidative conversion of the pyrrole-proline-guanidine pseudo-peptide to dispacamide A.

14 August 2018

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A microwave-assisted stereoselective synthesis of polyandrocarpamines A and B

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Crossref

https://api.crossref.org/works/10.3390/MD15100316

New leukotriene B4 receptor antagonist: leucettamine A and related imidazole alkaloids from the marine sponge Leucetta microraphis

21 January 2018

1 reference

12 December 2020

Synthesis and LTB4 receptor antagonist activities of the naturally occurring LTB4 receptor antagonist Leucettamine A and related analogues

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12 December 2020

Purification of GSK-3 by affinity chromatography on immobilized axin

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12 December 2020

An efficient approach to dispacamide A and its derivatives

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Synthesis of C(11)N(5) Marine Sponge Alkaloids: ( /-)-Hymenin, Stevensine, Hymenialdisine, and Debromohymenialdisine

1 reference

12 December 2020

Aplysinopsin: antineoplastic tryptophan derivative from the marine sponge Verongia spengelii

1 reference

12 December 2020

A new glycociamidine ring precursor: syntheses of (Z)-hymenialdisine, (Z)-2-debromohymenialdisine, and ( /-)-endo-2-debromohymenialdisine

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12 December 2020

Identifiers

DOI

10.3390/MD15100316

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29039762 AND SRC:MED&resulttype=core&format=json

7 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29039762 AND SRC:MED&resulttype=core&format=json

7 April 2020

PubMed publication ID

29039762

1 reference