Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202. (Q47249688)

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8 April 2020

title

Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202 (English)

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5

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8 April 2020

author name string

Michael C Gregory

1

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8 April 2020

Piotr J Mak

2

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8 April 2020

Yogan Khatri

3

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James R Kincaid

4

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8 April 2020

language of work or name

English

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publication date

24 January 2018

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8 April 2020

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volume

57

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issue

5

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page(s)

764-771

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Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin

8 April 2020

cites work

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Mechanism of Cytochrome P450 17A1-Catalyzed Hydroxylase and Lyase Reactions.

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Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis.

29 September 2018

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Unveiling the crucial intermediates in androgen production

29 September 2018

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Structures of human steroidogenic cytochrome P450 17A1 with substrates

29 September 2018

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Resonance Raman spectroscopy reveals that substrate structure selectively impacts the heme-bound diatomic ligands of CYP17.

29 September 2018

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Active site proton delivery and the lyase activity of human CYP17A1.

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Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: evidence for a reactive peroxoanion intermediate.

29 September 2018

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Differential hydrogen bonding in human CYP17 dictates hydroxylation versus lyase chemistry

29 September 2018

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Nanodiscs in the studies of membrane-bound cytochrome P450 enzymes.

29 September 2018

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CO, NO and O2 as Vibrational Probes of Heme Protein Interactions

29 September 2018

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Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001

29 September 2018

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Spectroscopic features of cytochrome P450 reaction intermediates

29 September 2018

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A review of mechanistic studies on aromatase (CYP19) and 17α-hydroxylase-17,20-lyase (CYP17)

29 September 2018

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At the crossroads of steroid hormone biosynthesis: the role, substrate specificity and evolutionary development of CYP17.

29 September 2018

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Functional reconstitution of monomeric CYP3A4 with multiple cytochrome P450 reductase molecules in Nanodiscs

29 September 2018

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Chapter 11 - Reconstitution of membrane proteins in phospholipid bilayer nanodiscs

29 September 2018

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Membrane protein assembly into Nanodiscs

29 September 2018

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Substrate- and isoform-specific dioxygen complexes of nitric oxide synthase.

29 September 2018

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Nanodiscs unravel the interaction between the SecYEG channel and its cytosolic partner SecA.

29 September 2018

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Ligand-protein interactions in nitric oxide synthase.

29 September 2018

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Molecular cloning and heterologous expression in E. coli of cytochrome P45017alpha. Comparison of structural and functional properties of substrate-specific cytochromes P450 from different species

29 September 2018

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Resonance Raman and EPR investigations of the D251N oxycytochrome P450cam/putidaredoxin complex

29 September 2018

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Simultaneous observation of the O—O and Fe—O2 stretching modes in oxyhemoglobins

29 September 2018

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Cytochrome b 5 Augments the 17,20-Lyase Activity of Human P450c17 without Direct Electron Transfer

29 September 2018

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Microsomal cytochrome P-450 from neonatal pig testis: two enzymatic activities (17 alpha-hydroxylase and c17,20-lyase) associated with one protein

29 September 2018

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Structural analysis of the FMN binding domain of NADPH-cytochrome P-450 oxidoreductase by site-directed mutagenesis

29 September 2018

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29 September 2018

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12 December 2020

Microsomal cytochrome P-450 from neonatal pig testis. Purification and properties of A C21 steroid side-chain cleavage system (17 alpha-hydroxylase-C17,20 lyase)

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12 December 2020

A Cooperative Oxygen Binding Hemoglobin fromMycobacterium tuberculosis

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12 December 2020

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12 December 2020

High-level expression in Escherichia coli and purification of the membrane-bound form of cytochrome b(5)

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12 December 2020

Specific hydrogen-bonding networks responsible for selective O2 sensing of the oxygen sensor protein HemAT from Bacillus subtilis

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Structural and functional properties of a truncated hemoglobin from a food-borne pathogen Campylobacter jejuni

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12 December 2020

10.1021/ACS.BIOCHEM.7B01067

Identifiers

DOI

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8 April 2020

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8 April 2020

PubMed publication ID

29283561

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