Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network (Q46967068)

26 December 2017

http://europepmc.org/abstract/MED/27064726

title

Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network (English)

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26 December 2017

http://europepmc.org/abstract/MED/27064726

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8

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3 June 2020

Luis C. López

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3 June 2020

Darío Acuña-Castroviejo

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3 June 2020

María E. Díaz-Casado

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3 June 2020

Ramy K Sayed

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3 June 2020

Ana Guerra-Librero

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Carolina Doerrier

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3 June 2020

Paula Aranda-Martínez

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Paula Aranda

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author name string

Elena Lima

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3 June 2020

José A García

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3 June 2020

publication date

11 April 2016

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26 December 2017

http://europepmc.org/abstract/MED/27064726

published in

Journal of Pineal Research

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volume

61

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issue

1

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page(s)

96-107

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Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo.

3 June 2020

cites work

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The teleostean (zebrafish) dopaminergic system ascending to the subpallium (striatum) is located in the basal diencephalon (posterior tuberculum).

21 January 2018

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Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio).

21 January 2018

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Dopaminergic cell damage and vulnerability to MPTP in Pink1 knockdown zebrafish

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Staging of brain pathology related to sporadic Parkinson's disease

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α-Synuclein in Lewy bodies

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Hypokinesia and reduced dopamine levels in zebrafish lacking β- and γ1-synucleins

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Discovery and characterization of three novel synuclein genes in zebrafish

21 January 2018

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Fish Synucleins: An Update

21 January 2018

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

21 January 2018

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

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Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

21 January 2018

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PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

21 January 2018

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Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice

21 January 2018

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The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease

21 January 2018

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Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons

21 January 2018

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Neuroprotective function of DJ-1 in Parkinson's disease

21 January 2018

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DJ-1 has a role in antioxidative stress to prevent cell death

21 January 2018

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Human DJ-1-specific Transcriptional Activation of Tyrosine Hydroxylase Gene

21 January 2018

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Parkinsonism genes: culprits and clues

21 January 2018

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Evidence for a common biological pathway linking three Parkinson's disease-causing genes: parkin, PINK1 and DJ-1

21 January 2018

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MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin

21 January 2018

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Expanding insights of mitochondrial dysfunction in Parkinson's disease.

21 January 2018

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Mitochondrial complex I deficiency in Parkinson's disease

21 January 2018

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Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity

21 January 2018

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A review of the melatonin functions in zebrafish physiology

21 January 2018

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Extrapineal melatonin: sources, regulation, and potential functions.

21 January 2018

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Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

21 January 2018

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Melatonin-mitochondria interplay in health and disease.

21 January 2018

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Melatonin, mitochondria, and cellular bioenergetics

21 January 2018

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Melatonin role in the mitochondrial function.

21 January 2018

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Melatonin relieves the neural oxidative burden that contributes to dementias

21 January 2018

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Protective effect of melatonin in a chronic experimental model of Parkinson's disease

21 January 2018

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Synergistic effects of melatonin and deprenyl against MPTP-induced mitochondrial damage and DA depletion

21 January 2018

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Melatonin and its brain metabolite N(1)-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice.

21 January 2018

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Zebrafish immunohistochemistry

21 January 2018

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MPTP and MPP target specific aminergic cell populations in larval zebrafish

21 January 2018

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In vivo and in organello assessment of OXPHOS activities

21 January 2018

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An evaluation of the measurement of the activities of complexes I-IV in the respiratory chain of human skeletal muscle mitochondria.

21 January 2018

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Mitochondria in the aetiology and pathogenesis of Parkinson's disease

21 January 2018

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Oxidative stress and Parkinson's disease

21 January 2018

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Role of oxidative stress in Parkinson's disease

21 January 2018

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Melatonin enhances L-DOPA therapeutic effects, helps to reduce its dose, and protects dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice

21 January 2018

1 reference

Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish

21 January 2018

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Innate inflammation in Parkinson's disease

21 January 2018

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The mitochondrial cascade hypothesis for Parkinson's disease

21 January 2018

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The Parkinson's disease-related genes act in mitochondrial homeostasis

21 January 2018

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Loss of PINK1 function affects development and results in neurodegeneration in zebrafish

21 January 2018

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

21 January 2018

1 reference

Recapitulation of zebrafish sncga expression pattern and labeling the habenular complex in transgenic zebrafish using green fluorescent protein reporter gene

21 January 2018

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Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.

21 January 2018

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Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

21 January 2018

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Biochemical properties of the kinase PINK1 as sensor protein for mitochondrial damage signalling

21 January 2018

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Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling

21 January 2018

1 reference

α-Synuclein-induced mitochondrial dysfunction in isolated preparation and intact cells: implications in the pathogenesis of Parkinson's disease

21 January 2018

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Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation.

21 January 2018

1 reference

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

21 January 2018

1 reference

Melatonin Improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro

21 January 2018

1 reference

Axon degeneration and PGC-1α-mediated protection in a zebrafish model of α-synuclein toxicity

21 January 2018

1 reference

Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin.

21 January 2018

1 reference

Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production

21 January 2018

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Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

21 January 2018

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21 January 2018

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Melatonin: an ancient molecule that makes oxygen metabolically tolerable.

21 January 2018

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Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease

21 January 2018

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Steps during the development of the zebrafish locomotor network

21 January 2018

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Mitochondrial biology, targets, and drug delivery.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JPI.12332

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27064726 AND SRC:MED&resulttype=core&format=json

3 June 2020

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