Oncogenic signaling of class I PI3K isoforms (Q46902768)

26 December 2017

title

Oncogenic signaling of class I PI3K isoforms (English)

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26 December 2017

author

Peter K. Vogt

4

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26 December 2017

author name string

A Denley

1

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26 December 2017

S Kang

2

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26 December 2017

U Karst

3

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26 December 2017

language of work or name

English

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publication date

12 November 2007

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26 December 2017

published in

Oncogene

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26 December 2017

volume

27

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26 December 2017

issue

18

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26 December 2017

page(s)

2561-2574

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26 December 2017

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

cites work

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

The akt kinase: molecular determinants of oncogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

The catalytic subunit of phosphoinositide 3-kinase: requirements for oncogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

A Specific Role of Phosphatidylinositol 3–Kinase γ

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Isoform specific inhibitors of PI3 kinase in glioma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Rare cancer-specific mutations in PIK3CA show gain of function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Signalling through Class I PI3Ks in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

PI 3-kinase p110beta: a new target for antithrombotic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

New Procedure for DNA Transfection with Polycation and Dimethyl Sulfoxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells: direct evidence of PI3K activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Discovery of a novel Raf kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Input from Ras is required for maximal PI(3)K signalling in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

C2-domains, structure and function of a universal Ca2 -binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

High frequency of mutations of the PIK3CA gene in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Signalling by PI3K isoforms: insights from gene-targeted mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Synthesis and function of 3-phosphorylated inositol lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Phosphoinositide 3-kinases: a conserved family of signal transducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

PI 3-kinases: hidden potentials revealed.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Therapeutic potential of phosphoinositide 3-kinase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

Over-expression of the p110beta but not p110alpha isoform of PI 3-kinase inhibits motility in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

7 January 2021

Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

7 January 2021

Mutation of the PIK3CA gene in ovarian and breast cancer

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

7 January 2021

PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

7 January 2021

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

7 January 2021

The C2 domain calcium-binding motif: structural and functional diversity

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

7 January 2021

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

7 January 2021

Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1210918

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210918

1 reference

26 December 2017

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26 December 2017