Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis. (Q46828081)

PubMed publication ID

28918190

25 December 2017

http://europepmc.org/abstract/MED/28918190

title

Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis (English)

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13 May 2020

1

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13 May 2020

Hana Algül

series ordinal

3

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13 May 2020

author name string

Ilya Gukovsky

series ordinal

2

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13 May 2020

Aida Habtezion

series ordinal

4

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13 May 2020

language of work or name

English

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publication date

13 September 2017

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PubMed publication ID

28918190

25 December 2017

http://europepmc.org/abstract/MED/28918190

published in

Gastroenterology

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13 May 2020

volume

153

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13 May 2020

issue

5

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13 May 2020

page(s)

1212-1226

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Activation of alveolar macrophages in lung injury associated with experimental acute pancreatitis is mediated by the liver

13 May 2020

cites work

1 reference

12 December 2020

The role of intercellular adhesion molecule 1 and neutrophils in acute pancreatitis and pancreatitis-associated lung injury

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12 December 2020

Phospholipase A2 mediates nitric oxide production by alveolar macrophages and acute lung injury in pancreatitis

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12 December 2020

Lipopolysaccharide-activated macrophages stimulate the synthesis of collagen type I and C-fibronectin in cultured pancreatic stellate cells

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12 December 2020

Trypsin stimulates production of cytokines from peritoneal macrophages in vitro and in vivo

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12 December 2020

Cerulein upregulates ICAM-1 in pancreatic acinar cells, which mediates neutrophil adhesion to these cells

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12 December 2020

Macrophages infiltrating the tissue in chronic pancreatitis express the chemokine receptor CCR5

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12 December 2020

Kupffer cell blockade reduces hepatic and systemic cytokine levels and lung injury in hemorrhagic pancreatitis in rats

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12 December 2020

Activation of pancreatic acinar cells on isolation from tissue: cytokine upregulation via p38 MAP kinase.

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12 December 2020

Mast cell distribution and activation in chronic pancreatitis

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12 December 2020

Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis

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12 December 2020

Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis

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12 December 2020

Pancreatic elastase induces liver injury by activating cytokine production within Kupffer cells via nuclear factor-Kappa B.

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12 December 2020

Regulation of Kupffer cell TNF gene expression during experimental acute pancreatitis: the role of p38-MAPK, ERK1/2, SAPK/JNK, and NF-kappaB

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12 December 2020

Liver injury during acute pancreatitis: the role of pancreatitis-associated ascitic fluid (PAAF), p38-MAPK, and caspase-3 in inducing hepatocyte apoptosis

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12 December 2020

Caerulein-induced acute pancreatitis inhibits protein synthesis through effects on eIF2B and eIF4F.

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12 December 2020

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

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12 December 2020

Chronic alcohol consumption accelerates fibrosis in response to cerulein-induced pancreatitis in rats

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12 December 2020

Treatment with bindarit, a blocker of MCP-1 synthesis, protects mice against acute pancreatitis

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12 December 2020

ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow

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12 December 2020

Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice

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12 December 2020

Neutrophil depletion--but not prevention of Kupffer cell activation--decreases the severity of cerulein-induced acute pancreatitis

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12 December 2020

Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury

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12 December 2020

Regulation and function of IKK and IKK-related kinases

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12 December 2020

Significant increase of serum high-mobility group box chromosomal protein 1 levels in patients with severe acute pancreatitis

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12 December 2020

Integrating cell-signalling pathways with NF-kappaB and IKK function

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12 December 2020

Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells

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12 December 2020

Acute pancreatitis: bench to the bedside.

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12 December 2020

Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo

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12 December 2020

Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis

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12 December 2020

The role of NF-kappaB activation in the pathogenesis of acute pancreatitis.

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12 December 2020

The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells

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12 December 2020

CD4 CD25 Foxp3 regulatory T cells induce alternative activation of human monocytes/macrophages.

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12 December 2020

Shared principles in NF-kappaB signaling

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12 December 2020

Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells

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12 December 2020

Mechanisms regulating cytochrome c release in pancreatic mitochondria.

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12 December 2020

From endoplasmic-reticulum stress to the inflammatory response

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12 December 2020

Endoplasmic reticulum stress and the pancreatic acinar cell

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12 December 2020

Impact of toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice

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12 December 2020

Impaired autolysosome formation correlates with Lamp-2 depletion: role of apoptosis, autophagy, and necrosis in pancreatitis

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12 December 2020

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

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12 December 2020

Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer.

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12 December 2020

Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis

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12 December 2020

Protective effects of MCP-1 inhibitor on a rat model of severe acute pancreatitis.

1 reference

12 December 2020

Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo

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12 December 2020

Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death

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12 December 2020

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

1 reference

12 December 2020

Role of CCL-2, CCR-2 and CCR-4 in cerulein-induced acute pancreatitis and pancreatitis-associated lung injury

1 reference

12 December 2020

Genetic and pharmacologic inhibition of the Ca2 influx channel TRPC3 protects secretory epithelia from Ca2 -dependent toxicity.

1 reference

12 December 2020

TLR9 and the NLRP3 Inflammasome Link Acinar Cell Death With Inflammation in Acute Pancreatitis

1 reference

12 December 2020

Cross-talk between the complement and the kinin system in vascular permeability

1 reference

12 December 2020

Myeloid, but Not Pancreatic, RelA/p65 Is Required for Fibrosis in a Mouse Model of Chronic Pancreatitis

1 reference

12 December 2020

Dendritic cells promote pancreatic viability in mice with acute pancreatitis.

1 reference

12 December 2020

Organellar dysfunction in the pathogenesis of pancreatitis

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12 December 2020

TLR4 but not TLR2 regulates inflammation and tissue damage in acute pancreatitis induced by retrograde infusion of taurocholate

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12 December 2020

Imaging of protease functions--current guide to spotting cysteine cathepsins in classical and novel scenes of action in mammalian epithelial cells and tissues

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12 December 2020

Cysteine cathepsins: from structure, function and regulation to new frontiers

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12 December 2020

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

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12 December 2020

Interleukin-22 ameliorates cerulein-induced pancreatitis in mice by inhibiting the autophagic pathway

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12 December 2020

NF-κB, the first quarter-century: remarkable progress and outstanding questions

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12 December 2020

Sterile inflammatory response in acute pancreatitis

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12 December 2020

Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice

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12 December 2020

The chemokine superfamily revisited

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12 December 2020

siRNA-based targeting of fractalkine overexpression suppresses inflammation development in a severe acute pancreatitis rat model

1 reference

12 December 2020

Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation

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12 December 2020

Burden of gastrointestinal disease in the United States: 2012 update

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12 December 2020

Autophagy and pancreatitis

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12 December 2020

Aryl hydrocarbon receptor regulates pancreatic IL-22 production and protects mice from acute pancreatitis

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12 December 2020

Activation of nuclear factor-κB in acinar cells increases the severity of pancreatitis in mice

1 reference

12 December 2020

Deletion of IκBα Activates RelA to Reduce Acute Pancreatitis in Mice Through Up-regulation of Spi2A

1 reference

12 December 2020

Pancreatic STAT3 protects mice against caerulein-induced pancreatitis via PAP1 induction

1 reference

12 December 2020

Effects of oxidative alcohol metabolism on the mitochondrial permeability transition pore and necrosis in a mouse model of alcoholic pancreatitis

1 reference

12 December 2020

Nuclear factor-κB in pancreatitis: Jack-of-all-trades, but which one is more important?

1 reference

12 December 2020

Role of janus kinase/signal transducers and activators of transcription in the pathogenesis of pancreatitis and pancreatic cancer.

1 reference

12 December 2020

Cerulein-induced chronic pancreatitis does not require intra-acinar activation of trypsinogen in mice

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12 December 2020

Autophagy in human health and disease

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12 December 2020

IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality

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12 December 2020

Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice

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12 December 2020

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

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12 December 2020

Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer

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12 December 2020

Genetic risk factors for pancreatic disorders

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12 December 2020

An overview of autophagy: morphology, mechanism, and regulation

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12 December 2020

Pancreas-specific Cre driver lines and considerations for their prudent use

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12 December 2020

New insights into the pathogenesis of pancreatitis

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12 December 2020

The role of Ca2 in the pathophysiology of pancreatitis

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12 December 2020

Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis

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12 December 2020

p53 status determines the role of autophagy in pancreatic tumour development

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12 December 2020

Carbon monoxide-based therapy ameliorates acute pancreatitis via TLR4 inhibition

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12 December 2020

Intracellular Hmgb1 inhibits inflammatory nucleosome release and limits acute pancreatitis in mice

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12 December 2020

Autophagy in the endocrine glands

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12 December 2020

Interleukin-6 in inflammatory and malignant diseases of the pancreas

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12 December 2020

Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity

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12 December 2020

The conspiracy of autophagy, stress and inflammation in acute pancreatitis

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12 December 2020

Endoplasmic reticulum stress is chronically activated in chronic pancreatitis

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12 December 2020

Cell death and DAMPs in acute pancreatitis

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12 December 2020

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12 December 2020

mTOR and autophagy: a dynamic relationship governed by nutrients and energy.

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12 December 2020

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12 December 2020

Impaired autophagy induces chronic atrophic pancreatitis in mice via sex- and nutrition-dependent processes

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12 December 2020

Impaired autophagy triggers chronic pancreatitis: lessons from pancreas-specific atg5 knockout mice

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Autophagy and inflammasome interplay.

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12 December 2020

CXCR2 inhibition suppresses acute and chronic pancreatic inflammation

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12 December 2020

Beyond indigestion: emerging roles for lysosome-based signaling in human disease

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12 December 2020

Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis

1 reference

12 December 2020

How mitochondrial dynamism orchestrates mitophagy

1 reference

12 December 2020

Intracellular calcium signaling regulates autophagy via calcineurin-mediated TFEB dephosphorylation

1 reference

12 December 2020

Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP.

1 reference

12 December 2020

Therapeutic targeting of autophagy in neurodegenerative and infectious diseases

1 reference

12 December 2020

Inflammation in acute and chronic pancreatitis

1 reference

12 December 2020

Modulation of inflammation by autophagy: Consequences for human disease

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12 December 2020

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology.

1 reference

12 December 2020

Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses.

1 reference

12 December 2020

Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice With Severe Acute Pancreatitis

1 reference

12 December 2020

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

1 reference

12 December 2020

Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress

1 reference

12 December 2020

BCL3 Reduces the Sterile Inflammatory Response in Pancreatic and Biliary Tissues.

1 reference

12 December 2020

Beyond starvation: An update on the autophagic machinery and its functions

1 reference

12 December 2020

Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis

1 reference

12 December 2020

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

1 reference

12 December 2020

Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

1 reference

12 December 2020

Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

1 reference

12 December 2020

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation.

1 reference

12 December 2020

Neutrophil extracellular traps - the dark side of neutrophils

1 reference

12 December 2020

Intracellular Ca(2 ) signaling and Ca(2 ) microdomains in the control of cell survival, apoptosis and autophagy

1 reference

12 December 2020

Human TBK1: A Gatekeeper of Neuroinflammation

1 reference

12 December 2020

The mTOR signalling cascade: paving new roads to cure neurological disease

1 reference

12 December 2020

New insights into the pathways initiating and driving pancreatitis.

1 reference

12 December 2020

Roles of mitophagy in cellular physiology and development

1 reference

12 December 2020

Priming of the neutrophil respiratory burst: role in host defense and inflammation.

1 reference

12 December 2020

Innate Immune Cell Trafficking and Function During Sterile Inflammation of the Liver

1 reference

12 December 2020

Subcellular redistribution of lysosomal enzymes during caerulein-induced pancreatitis

1 reference

12 December 2020

New insights into autophagosome-lysosome fusion

1 reference

12 December 2020

Fatal pancreatitis, a consequence of excessive leukocyte stimulation?

1 reference

12 December 2020

Intracellular transport of secretory proteins in the pancreatic exocrine cell. IV. Metabolic requirements

1 reference

12 December 2020

Supramaximal caerulein stimulation and ultrastructure of rat pancreatic acinar cell: early morphological changes during development of experimental pancreatitis

1 reference

12 December 2020

Pancreatic effects of ethionine: blockade of exocytosis and appearance of crinophagy and autophagy precede cellular necrosis

1 reference

12 December 2020

Human acute pancreatitis: a light and electron microscopic study

1 reference

12 December 2020

Pancreatic acinar ultrastructure in human acute pancreatitis

1 reference

12 December 2020

Lymphocyte homing and homeostasis

1 reference

12 December 2020

The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis

1 reference

12 December 2020

Mononuclear phagocyte activation and acute pancreatitis

1 reference

12 December 2020

Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-alpha. Role in regulating cell death and pancreatitis

1 reference

12 December 2020

The role of cytokines in the pathogenesis of acute pancreatitis

1 reference

12 December 2020

Early NF-kappaB activation is associated with hormone-induced pancreatitis.

1 reference

12 December 2020

Inhibition of nuclear factor-kappaB activation improves the survival of rats with taurocholate pancreatitis

1 reference

12 December 2020

NF-kappaB/Rel activation in cerulein pancreatitis

1 reference

12 December 2020

10.1053/J.GASTRO.2017.08.071

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6338477&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6338477&resulttype=core&format=json

13 May 2020

PubMed publication ID

28918190

1 reference