Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis. (Q46818675)

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scientific article published in November 2005

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English	Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.	scientific article published in November 2005

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16306400

Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725876&resulttype=core&format=json

12 May 2020

Alzheimer's disease

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author name string

Rodney A Velliquette

1

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725876&resulttype=core&format=json

12 May 2020

Tracy O'Connor

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725876&resulttype=core&format=json

12 May 2020

Robert Vassar

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725876&resulttype=core&format=json

12 May 2020

language of work or name

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publication date

1 November 2005

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/16306400

Journal of Neuroscience

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725876&resulttype=core&format=json

12 May 2020

25

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725876&resulttype=core&format=json

12 May 2020

47

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725876&resulttype=core&format=json

12 May 2020

10874-10883

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725876&resulttype=core&format=json

12 May 2020

Energy metabolism inhibition impairs amyloid precursor protein secretion from Alzheimer's fibroblasts.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translational control: the cancer connection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Function and dysfunction of the presenilins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical threshold cerebral hypoperfusion causes Alzheimer's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo PET imaging and postmortem studies suggest potentially reversible and irreversible stages of brain metabolic failure in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the low-density lipoprotein receptor-related protein in beta-amyloid metabolism and Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular risk factors for Alzheimer's disease: an epidemiologic perspective.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular abnormalities: the insidious pathogenesis of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The functions of the amyloid precursor protein gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal formation glucose metabolism and volume losses in MCI and AD.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral blood flow and metabolic abnormalities in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A portrait of Alzheimer secretases--new features and familiar faces

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrogliosis in the adult and developing CNS: is there a role for proinflammatory cytokines?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral hypoperfusion generates cortical watershed microinfarcts in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress increases expression and activity of BACE in NT2 neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain SPET abnormalities in Alzheimer's disease before and after atrophy correction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

alpha- and beta-secretase: profound changes in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP processing and synaptic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circle of Willis Atherosclerosis Is a Risk Factor for Sporadic Alzheimer’s Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gleevec inhibits β-amyloid production but not Notch cleavage

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dehydroepiandrosterone reduces expression and activity of BACE in NT2 neurons exposed to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mouse strain differences in kainic acid sensitivity, seizure behavior, mortality, and hippocampal pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential utilization of upstream AUGs in the beta-secretase mRNA suggests that a shunting mechanism regulates translation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translational regulation of BACE-1 expression in neuronal and non-neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental traumatic brain injury in rats stimulates the expression, production and activity of Alzheimer's disease beta-secretase (BACE-1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE (beta-secretase) modulates the processing of APLP2 in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased beta-secretase activity and expression in rats following transient cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ischemic nephropathy: where are we now?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contrasting metabolic impairment in frontotemporal degeneration and early onset Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative stress potentiates BACE1 gene expression and Abeta generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atherosclerosis and AD: analysis of data from the US National Alzheimer's Coordinating Center

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease. FDG-PET studies in MCI and AD.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APOE, vascular pathology, and the AD brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormal brain glucose metabolism in Alzheimer's disease, as measured by position emission tomography

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid plaque core protein in Alzheimer disease and Down syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain metabolism as measured with positron emission tomography: serial assessment in a patient with familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positron emission tomographic studies of aging and Alzheimer disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The distribution of hypoglycemic brain damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Computed tomography and positron emission transaxial tomography evaluations of normal aging and Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid rate of decline in cerebral blood flow in progressive dementias.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in brain glucose metabolism as a key to the pathogenesis of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of A beta 42 in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of perturbed energy metabolism on the processing of amyloid precursor protein in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16306400

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.2350-05.2005

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725876&resulttype=core&format=json

12 May 2020

release_cjrkzwaourddrhq2kajdnppuby

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https://api.fatcat.wiki/v0/release/cjrkzwaourddrhq2kajdnppuby

24 November 2022

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725876&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725876&resulttype=core&format=json

12 May 2020

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