Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death (Q46816485)

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English	Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/25381820

Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death (English)

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/25381820

1 reference

based on heuristic

inferred from title

lymphoblastic leukemia

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based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

4

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/25381820

author name string

H Schoeneberger

1

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/25381820

K Belz

2

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/25381820

B Schenk

3

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/25381820

language of work or name

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publication date

10 November 2014

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Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/25381820

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/25381820

34

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/25381820

31

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/25381820

4032-4043

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/25381820

Treatment of childhood acute lymphoblastic leukemia

1 reference

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Tumor resistance to apoptosis

1 reference

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Therapeutic opportunities for counteracting apoptosis resistance in childhood leukaemia

1 reference

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Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

1 reference

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21 January 2018

Targeting IAP proteins for therapeutic intervention in cancer

1 reference

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21 January 2018

XIAP expression is post-transcriptionally upregulated in childhood ALL and is associated with glucocorticoid response in T-cell ALL.

1 reference

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21 January 2018

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

1 reference

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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

1 reference

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21 January 2018

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

1 reference

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21 January 2018

Redox regulation of cell survival

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21 January 2018

Redox control of leukemia: from molecular mechanisms to therapeutic opportunities

1 reference

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Modulation of oxidative stress as an anticancer strategy

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Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells

1 reference

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21 January 2018

Glutathione peroxidases

1 reference

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21 January 2018

Regulation of ferroptotic cancer cell death by GPX4

1 reference

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A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells

1 reference

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Buthionine sulfoximine enhancement of arsenic trioxide-induced apoptosis in leukemia and lymphoma cells is mediated via activation of c-Jun NH2-terminal kinase and up-regulation of death receptors.

1 reference

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21 January 2018

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

1 reference

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Selective fluorescent imaging of superoxide in vivo using ethidium-based probes

1 reference

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21 January 2018

Metalloporphyrins are potent inhibitors of lipid peroxidation

1 reference

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Mammalian mitochondrial complex I: biogenesis, regulation, and reactive oxygen species generation.

1 reference

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Vitamin E protects against lipid peroxidation and rescues tumorigenic phenotypes in cowden/cowden-like patient-derived lymphoblast cells with germline SDHx variants

1 reference

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Oxygen toxicity, oxygen radicals, transition metals and disease

1 reference

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Ferroptosis: an iron-dependent form of nonapoptotic cell death

1 reference

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RIP1 protein-dependent assembly of a cytosolic cell death complex is required for inhibitor of apoptosis (IAP) inhibitor-mediated sensitization to lexatumumab-induced apoptosis

1 reference

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21 January 2018

RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis

1 reference

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21 January 2018

RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.338

21 January 2018

Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis

1 reference

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21 January 2018

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

1 reference

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21 January 2018

Fluorescence probes used for detection of reactive oxygen species

1 reference

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Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

1 reference

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21 January 2018

Glutathione depletion and disruption of intracellular ionic homeostasis regulate lymphoid cell apoptosis

1 reference

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21 January 2018

Apoptosis and glutathione: beyond an antioxidant.

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.338

21 January 2018

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.338

21 January 2018

Oxidatively truncated phospholipids are required agents of tumor necrosis factor α (TNFα)-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.338

21 January 2018

Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

1 reference

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21 January 2018

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.338

21 January 2018

Inhibitor of Apoptosis (IAP) proteins in hematological malignancies: molecular mechanisms and therapeutic opportunities

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.338

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Inhibitor of apoptosis proteins in pediatric leukemia: molecular pathways and novel approaches to therapy

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.338

21 January 2018

High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.338

21 January 2018

Raised blast glutathione levels are associated with an increased risk of relapse in childhood acute lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038/ONC.2014.338

21 January 2018

Molecular pathways: targeting inhibitor of apoptosis proteins in cancer--from molecular mechanism to therapeutic application

1 reference

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Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

1 reference

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Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process.

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Interleukin-1-induced nuclear factor κB activation is inhibited by overexpression of phospholipid hydroperoxide glutathione peroxidase in a human endothelial cell line

1 reference

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Smac mimetic and glucocorticoids synergize to induce apoptosis in childhood ALL by promoting ripoptosome assembly

1 reference

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21 January 2018

Acute lymphoblastic leukemia

1 reference

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Manganic Porphyrins Possess Catalase Activity and Protect Endothelial Cells against Hydrogen Peroxide-Mediated Injury

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Effect of N-acetylcysteine on blood and tissue lipid peroxidation in lipopolysaccharide-induced obstructive jaundice

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A fluorometric method for measurement of peroxyl radical scavenging activities of lipophilic antioxidants

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Phase I Study of Continuous-Infusion L-S,R-Buthionine Sulfoximine With Intravenous Melphalan

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Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance

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31 March 2020

Comparison of dose-effect relationships of carcinogens following low-dose chronic exposure and high-dose single injection: an analysis by the median-effect principle

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Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis

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Differences in the expression pattern of apoptosis-related molecules between childhood and adult de novo acute myeloid leukemia.

1 reference

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Functional CD95 ligand and CD95 death-inducing signaling complex in activation-induced cell death and doxorubicin-induced apoptosis in leukemic T cells.

1 reference

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Vitamin E analogue Trolox C. E.s.r. and pulse-radiolysis studies of free-radical reactions

1 reference

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Raised intracellular glutathione levels correlate with in vitro resistance to cytotoxic drugs in leukaemic cells from patients with acute lymphoblastic leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25381820

12 December 2020

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inferred from PubMed ID database lookup

Identifiers

10.1038/ONC.2014.338

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/25381820

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 December 2017

http://europepmc.org/abstract/MED/25381820

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