Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy"). (Q46691801)

24 December 2017

http://europepmc.org/abstract/MED/18354027

title

Enhanced tau phosphorylation in the hippocampus of mice treated with 3,4-methylenedioxymethamphetamine ("Ecstasy"). (English)

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24 December 2017

http://europepmc.org/abstract/MED/18354027

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2

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16 May 2020

Carla L Busceti

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16 May 2020

Giuseppe Battaglia

4

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Valeria Maria Gloria Bruno

16 May 2020

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16 May 2020

Ferdinando Nicoletti

12

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16 May 2020

Francesco Fornai

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16 May 2020

9

Andrea Caricasole

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16 May 2020

author name string

Barbara Riozzi

3

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16 May 2020

Marianna Storto

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16 May 2020

Carlo Cinque

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Gemma Molinaro

7

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16 May 2020

Roberto Gradini

8

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16 May 2020

Anna Maria Canudas

10

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16 May 2020

language of work or name

English

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publication date

1 March 2008

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24 December 2017

http://europepmc.org/abstract/MED/18354027

published in

Journal of Neuroscience

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16 May 2020

volume

28

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16 May 2020

issue

12

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16 May 2020

page(s)

3234-3245

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Overexpression of human copper/zinc superoxide dismutase in transgenic mice attenuates oxidative stress caused by methylenedioxymethamphetamine (Ecstasy).

16 May 2020

cites work

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12 December 2020

The acute effect in rats of 3,4-methylenedioxyethamphetamine (MDEA, "eve") on body temperature and long term degeneration of 5-HT neurones in brain: a comparison with MDMA ("ecstasy").

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Effects of antihistamines on 3, 4-methylenedioxymethamphetamine-induced depletion of serotonin in rats

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Level of use of 3,4-methylenedioxymethamphetamine (MDMA or Ecstasy) in humans correlates with EEG power and coherence

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Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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12 December 2020

Mood state and brain electric activity in ecstasy users

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12 December 2020

Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53.

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Neurotoxicity induces cleavage of p35 to p25 by calpain

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12 December 2020

Processing of cdk5 Activator p35 to Its Truncated Form (p25) by Calpain in Acutely Injured Neuronal Cells

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12 December 2020

Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration

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12 December 2020

Effect of GBR 12909 and fluoxetine on the acute and long term changes induced by MDMA ('ecstasy') on the 5-HT and dopamine concentrations in mouse brain

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12 December 2020

Induction of cyclin-dependent kinase 5 in the hippocampus by chronic electroconvulsive seizures: role of [Delta]FosB.

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Memory impairment in abstinent MDMA ("Ecstasy") users: a longitudinal investigation

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12 December 2020

ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1.

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12 December 2020

3,4-Methylenedioxymethamphetamine induces monoamine release, but not toxicity, when administered centrally at a concentration occurring following a peripherally injected neurotoxic dose

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Involvement of free radicals in MDMA-induced neurotoxicity in mice.

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A study of the mechanisms involved in the neurotoxic action of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') on dopamine neurones in mouse brain

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p53 regulation of DNA excision repair pathways

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Cyclin dependent kinase 5 and its interacting proteins in cell death induced in vivo by cyclophosphamide in developing mouse embryos

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A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

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12 December 2020

Pharmacological inhibitors of cyclin-dependent kinases

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Pentylenetetrazol-kindling of seizures selectively decreases [3H]-citalopram binding in the CA-3 area of rat hippocampus

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Distribution and morphology of serotonin-immunoreactive axons in the hippocampal region of the New Zealand white rabbit. I. Area dentata and hippocampus.

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Cdk5: One of the links between senile plaques and neurofibrillary tangles?

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Inhibition of protein phosphatase 2A- and protein phosphatase 1-induced tau hyperphosphorylation and impairment of spatial memory retention in rats

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12 December 2020

Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanisms

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12 December 2020

The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").

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12 December 2020

Long-term alteration in the central monoaminergic systems of the rat by 2,4,5-trihydroxyamphetamine but not by 2-hydroxy-4,5-methylenedioxymethamphetamine or 2-hydroxy-4,5-methylenedioxyamphetamine

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12 December 2020

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau

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12 December 2020

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

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12 December 2020

Preliminary evidence of hippocampal dysfunction in adolescent MDMA ("ecstasy") users: possible relationship to neurotoxic effects

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12 December 2020

The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator

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12 December 2020

Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory.

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12 December 2020

Hypomorphic expression of Dkk1 in the doubleridge mouse: dose dependence and compensatory interactions with Lrp6.

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12 December 2020

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain

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12 December 2020

Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors mediate glutamate-induced cleavage of the cyclin-dependent kinase 5 (cdk5) activator p35 in cultured rat hippocampal neurons

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12 December 2020

Effect of repeated ('binge') dosing of MDMA to rats housed at normal and high temperature on neurotoxic damage to cerebral 5-HT and dopamine neurones

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12 December 2020

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12 December 2020

Induction of cyclin-dependent kinase 5 and its activator p35 through the extracellular-signal-regulated kinase and protein kinase A pathways during retinoic-acid mediated neuronal differentiation in human neuroblastoma SK-N-BE(2)C cells

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12 December 2020

The effect of cdk-5 overexpression on tau phosphorylation and spatial memory of rat.

1 reference

12 December 2020

The potential roles of p53 tumor suppressor in nucleotide excision repair (NER) and base excision repair (BER).

1 reference

12 December 2020

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.

1 reference

12 December 2020

3,4-Methylenedioxymethamphetamine increases pro-interleukin-1beta production and caspase-1 protease activity in frontal cortex, but not in hypothalamus, of Dark Agouti rats: role of interleukin-1beta in neurotoxicity

1 reference

12 December 2020

Previous exposure to ( /-) 3,4-methylenedioxymethamphetamine produces long-lasting alteration in limbic brain excitability measured by electroencephalogram spectrum analysis, brain metabolism and seizure susceptibility.

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12 December 2020

Involvement of the CA3-CA1 synapse in the acquisition of associative learning in behaving mice.

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12 December 2020

Memory impairment in now abstinent MDMA users and continued users: a longitudinal follow-up

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12 December 2020

3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings

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12 December 2020

Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity

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12 December 2020

The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation

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12 December 2020

Interplay between the p53 tumor suppressor protein family and Cdk5: novel therapeutic approaches for the treatment of neurodegenerative diseases using selective Cdk inhibitors

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12 December 2020

Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target

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12 December 2020

PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners

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12 December 2020

Regulation of phosphorylation of tau by protein kinases in rat brain

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12 December 2020

Function and biological roles of the Dickkopf family of Wnt modulators

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12 December 2020

Neurodegeneration caused by expression of human truncated tau leads to progressive neurobehavioural impairment in transgenic rats

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12 December 2020

Oxidative stress in rat retina and hippocampus after chronic MDMA ('ecstasy') administration.

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12 December 2020

Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy

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12 December 2020

Neurotoxicity of substituted amphetamines: molecular and cellular mechanisms

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12 December 2020

3-Nitropropionic acid activates calpain/cdk5 pathway in rat striatum

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12 December 2020

Ecstasy induces apoptosis via 5-HT(2A)-receptor stimulation in cortical neurons

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12 December 2020

DNA fragmentation and oxidative stress in the hippocampal formation: a bridge between 3,4-methylenedioxymethamphetamine (ecstasy) intake and long-lasting behavioral alterations

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12 December 2020

Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity

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12 December 2020

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

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12 December 2020

Estimation of nuclear population from microtome sections

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12 December 2020

Differences in the central serotonergic effects of methylenedioxymethamphetamine (MDMA) in mice and rats

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12 December 2020

Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease

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12 December 2020

Differences between rats and mice in MDMA (methylenedioxymethylamphetamine) neurotoxicity.

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12 December 2020

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

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12 December 2020

Developments of a water-maze procedure for studying spatial learning in the rat

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Involvement of oxidative and L-arginine-NO pathways in the neurotoxicity of drugs of abuse in vitro

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CuZn-superoxide dismutase (CuZnSOD) transgenic mice show resistance to the lethal effects of methylenedioxyamphetamine (MDA) and of methylenedioxymethamphetamine (MDMA).

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12 December 2020

Chronic 3,4-methylenedioxymethamphetamine administration decreases glucocorticoid and mineralocorticoid receptor, but increases 5-hydroxytryptamine1C receptor gene expression in the rat hippocampus

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12 December 2020

Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse

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12 December 2020

Effects of ritanserin on the 3,4-methylenedioxymethamphetamine-induced decrease in striatal serotonin concentration and on the increase in striatal neurotensin and dynorphin A concentrations

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12 December 2020

Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin

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12 December 2020

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

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12 December 2020

Superoxide radicals mediate the biochemical effects of methylenedioxymethamphetamine (MDMA): evidence from using CuZn-superoxide dismutase transgenic mice

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12 December 2020

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

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12 December 2020

A molecular mechanism for the effect of lithium on development

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12 December 2020

Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3 beta and cyclin-dependent kinase 5, a component of TPK II.

1 reference

12 December 2020

Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain

1 reference

12 December 2020

Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau

1 reference

12 December 2020

Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration

1 reference

12 December 2020

β-catenin is a target for the ubiquitin–proteasome pathway

1 reference

12 December 2020

Differential toxic effects of methamphetamine (METH) and methylenedioxymethamphetamine (MDMA) in multidrug-resistant (mdr1a) knockout mice

1 reference

12 December 2020

Beta-catenin: a key mediator of Wnt signaling

1 reference

12 December 2020

Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration

1 reference

12 December 2020

Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neurons in human beings

1 reference

12 December 2020

10.1523/JNEUROSCI.0159-08.2008

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670724&resulttype=core&format=json

16 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6670724&resulttype=core&format=json

16 May 2020

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