Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice (Q46533399)

22 December 2017

http://europepmc.org/abstract/MED/26192747

title

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice (English)

1 reference

22 December 2017

http://europepmc.org/abstract/MED/26192747

author

Meaghan Morris

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747 AND SRC:MED&resulttype=core&format=json

14 June 2020

Sumihiro Maeda

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747 AND SRC:MED&resulttype=core&format=json

14 June 2020

7

Lennart Mucke

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747 AND SRC:MED&resulttype=core&format=json

14 June 2020

author name string

Giselle M Knudsen

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747 AND SRC:MED&resulttype=core&format=json

14 June 2020

Jonathan C Trinidad

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747 AND SRC:MED&resulttype=core&format=json

14 June 2020

Alexandra Ioanoviciu

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747 AND SRC:MED&resulttype=core&format=json

14 June 2020

Alma L Burlingame

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747 AND SRC:MED&resulttype=core&format=json

14 June 2020

language of work or name

English

0 references

publication date

20 July 2015

1 reference

22 December 2017

http://europepmc.org/abstract/MED/26192747

published in

Nature Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747 AND SRC:MED&resulttype=core&format=json

14 June 2020

volume

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747 AND SRC:MED&resulttype=core&format=json

14 June 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747 AND SRC:MED&resulttype=core&format=json

14 June 2020

page(s)

1183-1189

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747 AND SRC:MED&resulttype=core&format=json

14 June 2020

cites work

The many faces of tau

1 reference

Alzheimer mechanisms and therapeutic strategies

21 January 2018

1 reference

Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

21 January 2018

1 reference

Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.

21 January 2018

1 reference

Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

21 January 2018

1 reference

Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease.

21 January 2018

1 reference

Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

21 January 2018

1 reference

Antisense reduction of tau in adult mice protects against seizures

21 January 2018

1 reference

Tau reduction prevents disease in a mouse model of Dravet syndrome

21 January 2018

1 reference

Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.

21 January 2018

1 reference

Seizure resistance without parkinsonism in aged mice after tau reduction

21 January 2018

1 reference

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

21 January 2018

1 reference

Aβ Oligomers Cause Localized Ca2 Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

21 January 2018

1 reference

Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity.

21 January 2018

1 reference

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation

21 January 2018

1 reference

Dual modification of Alzheimer's disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach

21 January 2018

1 reference

O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease

21 January 2018

1 reference

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

21 January 2018

1 reference

The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine

21 January 2018

1 reference

Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry

21 January 2018

1 reference

Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis

21 January 2018

1 reference

Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

21 January 2018

1 reference

The acetylation of tau inhibits its function and promotes pathological tau aggregation

21 January 2018

1 reference

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

21 January 2018

1 reference

Acetylation of tau inhibits its degradation and contributes to tauopathy

21 January 2018

1 reference

Modification site localization scoring integrated into a search engine.

21 January 2018

1 reference

A probability-based approach for high-throughput protein phosphorylation analysis and site localization

21 January 2018

1 reference

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

21 January 2018

1 reference

Protein PTMs: post-translational modifications or pesky trouble makers?

21 January 2018

1 reference

Non-histone protein methylation as a regulator of cellular signalling and function

21 January 2018

1 reference

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

21 January 2018

1 reference

Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice

21 January 2018

1 reference

Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease

21 January 2018

1 reference

Mapping O-GlcNAc modification sites on tau and generation of a site-specific O-GlcNAc tau antibody

21 January 2018

1 reference

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

21 January 2018

1 reference

Tau isoform regulation is region- and cell-specific in mouse brain.

21 January 2018

1 reference

Lysine acetylation: codified crosstalk with other posttranslational modifications

21 January 2018

1 reference

The development of cell processes induced by tau protein requires phosphorylation of serine 262 and 356 in the repeat domain and is inhibited by phosphorylation in the proline-rich domains

21 January 2018

1 reference

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

21 January 2018

1 reference

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

21 January 2018

1 reference

Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain

21 January 2018

1 reference

Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases

21 January 2018

1 reference

Nuclear tau, a key player in neuronal DNA protection

21 January 2018

1 reference

Tau domains, phosphorylation, and interactions with microtubules.

21 January 2018

1 reference

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

21 January 2018

1 reference

Overexpression of wild-type human APP in mice causes cognitive deficits and pathological features unrelated to Abeta levels.

21 January 2018

1 reference

Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia.

21 January 2018

1 reference

High-yield purification of fetal tau preserving its structure and phosphorylation pattern

21 January 2018

1 reference

Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice

21 January 2018

1 reference

Phosphorylation state of postsynaptic density proteins

21 January 2018

1 reference

Comprehensive identification of phosphorylation sites in postsynaptic density preparations

21 January 2018

1 reference

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.

21 January 2018

1 reference

Identification of protein O-GlcNAcylation sites using electron transfer dissociation mass spectrometry on native peptides

21 January 2018

1 reference

Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse

21 January 2018

1 reference

O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry

21 January 2018

1 reference

Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap

21 January 2018

1 reference

In-depth analysis of tandem mass spectrometry data from disparate instrument types

21 January 2018

1 reference

Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry

21 January 2018

1 reference

A data processing pipeline for mammalian proteome dynamics studies using stable isotope metabolic labeling

21 January 2018

1 reference

Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer's NFTs

21 January 2018

1 reference

Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease

21 January 2018

1 reference

Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments

21 January 2018

1 reference

12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

12 December 2020

Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice.

1 reference

12 December 2020

Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.

1 reference

12 December 2020

Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure

1 reference

12 December 2020

Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization

1 reference

12 December 2020

Identifiers

DOI

10.1038/NN.4067

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26192747 AND SRC:MED&resulttype=core&format=json

14 June 2020

1 reference