Chemical genetics unveils a key role of mitochondrial dynamics, cytochrome c release and IP3R activity in muscular dystrophy (Q46484109)

22 December 2017

title

Chemical genetics unveils a key role of mitochondrial dynamics, cytochrome c release and IP3R activity in muscular dystrophy (English)

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22 December 2017

Kathrin Gieseler

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Jean Giacomotto

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Jean Giacomotto

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Joachim Berger

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Joachim Berger

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Peter D. Currie

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Peter D Currie

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author name string

Nicolas Brouilly

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Ludivine Walter

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Marie-Christine Mariol

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Laurent Ségalat

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Thomas S Becker

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publication date

25 June 2013

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22 December 2017

published in

Human Molecular Genetics

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22 December 2017

volume

22

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issue

22

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page(s)

4562-4578

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Complete cloning of the duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals

cites work

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The dystrophin-glycoprotein complex, cellular signaling, and the regulation of cell survival in the muscular dystrophies

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High-throughput screening and small animal models, where are we?

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Caenorhabditis elegans as a chemical screening tool for the study o f neuromuscular disorders. Manual and semi-automated methods

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Pre-clinical study of 21 approved drugs in the mdx mouse

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Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy

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Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

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CED-9 and mitochondrial homeostasis in C. elegans muscle

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Functions and dysfunctions of mitochondrial dynamics

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The pathophysiology of mitochondrial cell death

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

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The cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects in Col6a1-/- myopathic mice.

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21 January 2018

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 January 2018

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Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

21 January 2018

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Evaluation of exon-skipping strategies for Duchenne muscular dystrophy utilizing dystrophin-deficient zebrafish

21 January 2018

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Real-time imaging of mitochondria in transgenic zebrafish expressing mitochondrially targeted GFP.

21 January 2018

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The mitochondrion in apoptosis: how Pandora's box opens

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Recombinant expression, biophysical characterization, and cardiolipin-induced changes of two Caenorhabditis elegans cytochrome c proteins

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Mitochondrial involvement in cell death of non-mammalian eukaryotes

21 January 2018

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Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

21 January 2018

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A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways

21 January 2018

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Carboxyl-terminal sequences critical for inositol 1,4,5-trisphosphate receptor subunit assembly

21 January 2018

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Regulated disruption of inositol 1,4,5-trisphosphate signaling in Caenorhabditis elegans reveals new functions in feeding and embryogenesis

21 January 2018

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Inositol 1,4,5-trisphosphate signaling regulates rhythmic contractile activity of myoepithelial sheath cells in Caenorhabditis elegans

21 January 2018

1 reference

Inositol 1,4,5-trisphosphate signaling regulates mating behavior in Caenorhabditis elegans males

21 January 2018

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Treatment of Duchenne muscular dystrophy with ciclosporin A: a randomised, double-blind, placebo-controlled multicentre trial

21 January 2018

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The calcineurin signal transduction pathway is essential for successful muscle regeneration in mdx dystrophic mice.

21 January 2018

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Dose translation from animal to human studies revisited

21 January 2018

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Investigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy

21 January 2018

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Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

21 January 2018

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Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice

21 January 2018

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Inositol 1,4,5-trisphosphate receptors as signal integrators

21 January 2018

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Degradation of inositol 1,4,5-trisphosphate receptors during cell stimulation is a specific process mediated by cysteine protease activity

21 January 2018

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Phospholipase C-epsilon regulates epidermal morphogenesis in Caenorhabditis elegans

21 January 2018

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Mitochondrial disorders as windows into an ancient organelle

21 January 2018

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Defects in mitochondrial localization and ATP synthesis in the mdx mouse model of Duchenne muscular dystrophy are not alleviated by PDE5 inhibition

21 January 2018

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Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

21 January 2018

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21 January 2018

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The Caenorhabditis elegans gene unc-89, required fpr muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains

21 January 2018

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The stn-1 syntrophin gene of C.elegans is functionally related to dystrophin and dystrobrevin.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/HMG/DDT302

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22 December 2017

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22 December 2017