The aquaporin-4 water channel as a potential drug target in neurological disorders. (Q46364880)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29072508 AND SRC:MED&resulttype=core&format=json

8 April 2020

title

The aquaporin-4 water channel as a potential drug target in neurological disorders (English)

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8 April 2020

author name string

Alan S Verkman

1

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8 April 2020

Alex J Smith

2

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8 April 2020

Puay-Wah Phuan

3

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8 April 2020

Lukmanee Tradtrantip

4

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8 April 2020

Marc O Anderson

5

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8 April 2020

language of work or name

English

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publication date

5 November 2017

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Expert Opinion on Therapeutic Targets

8 April 2020

published in

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8 April 2020

volume

21

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8 April 2020

issue

12

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8 April 2020

page(s)

1161-1170

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Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke.

8 April 2020

cites work

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Super-resolution imaging of aquaporin-4 orthogonal arrays of particles in cell membranes.

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cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units

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Aquaporin-4 Mz isoform: brain expression, supramolecular assembly and neuromyelitis optica antibody binding

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Evidences for a leaky scanning mechanism for the synthesis of the shorter M23 protein isoform of aquaporin-4: implication in orthogonal array formation and neuromyelitis optica antibody interaction

21 January 2018

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Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance

21 January 2018

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Very high single channel water permeability of aquaporin-4 in baculovirus-infected insect cells and liposomes reconstituted with purified aquaporin-4.

21 January 2018

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Structure and Functions of Aquaporin-4-Based Orthogonal Arrays of Particles

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Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections

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Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging

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Heterotetrameric composition of aquaporin-4 water channels.

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Live cell analysis of aquaporin-4 m1/m23 interactions and regulated orthogonal array assembly in glial cells

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Model of Aquaporin-4 Supramolecular Assembly in Orthogonal Arrays Based on Heterotetrameric Association of M1-M23 Isoforms

21 January 2018

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Aggregation state determines the localization and function of M1- and M23-aquaporin-4 in astrocytes

21 January 2018

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Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein

21 January 2018

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Delayed onset of brain edema and mislocalization of aquaporin-4 in dystrophin-null transgenic mice

21 January 2018

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Binding Affinity and Specificity of Neuromyelitis Optica Autoantibodies to Aquaporin-4 M1/M23 Isoforms and Orthogonal Arrays

21 January 2018

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Improved long-term outcome after transient cerebral ischemia in aquaporin-4 knockout mice

21 January 2018

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Neuroprotective effect of aquaporin-4 deficiency in a mouse model of severe global cerebral ischemia produced by transient 4-vessel occlusion.

21 January 2018

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Greatly improved survival and neuroprotection in aquaporin-4-knockout mice following global cerebral ischemia

21 January 2018

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Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling.

21 January 2018

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Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess.

21 January 2018

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Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice.

21 January 2018

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A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

21 January 2018

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Spatial model of convective solute transport in brain extracellular space does not support a "glymphatic" mechanism.

21 January 2018

1 reference

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Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma.

21 January 2018

1 reference

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Microfiberoptic measurement of extracellular space volume in brain and tumor slices based on fluorescent dye partitioning

21 January 2018

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Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice.

21 January 2018

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Mildly Reduced Brain Swelling and Improved Neurological Outcome in Aquaporin-4 Knockout Mice following Controlled Cortical Impact Brain Injury.

21 January 2018

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Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption.

21 January 2018

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Involvement of aquaporin-4 in astroglial cell migration and glial scar formation

21 January 2018

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Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury

21 January 2018

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Impaired hearing in mice lacking aquaporin-4 water channels

21 January 2018

1 reference

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Impaired olfaction in mice lacking aquaporin-4 water channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/14728222.2017.1398236

Increased seizure threshold in mice lacking aquaporin-4 water channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/14728222.2017.1398236

Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels.

21 January 2018

1 reference

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K waves in brain cortex visualized using a long-wavelength K -sensing fluorescent indicator.

21 January 2018

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Aquaporin-4 regulates the velocity and frequency of cortical spreading depression in mice.

21 January 2018

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Evidence against functional interaction between aquaporin-4 water channels and Kir4.1 potassium channels in retinal Müller cells.

21 January 2018

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Aquaporin-4-dependent K( ) and water transport modeled in brain extracellular space following neuroexcitation

21 January 2018

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Impairment of Select Forms of Spatial Memory and Neurotrophin-Dependent Synaptic Plasticity by Deletion of Glial Aquaporin-4

21 January 2018

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Aquaporin-4 knockout regulated cocaine-induced behavior and neurochemical changes in mice

21 January 2018

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Proinflammatory role of aquaporin‐4 in autoimmune neuroinflammation

21 January 2018

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Critical role of aquaporin-4 (AQP4) in astrocytic Ca2 signaling events elicited by cerebral edema

21 January 2018

1 reference

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An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes

21 January 2018

1 reference

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Selected cysteine point mutations confer mercurial sensitivity to the mercurial-insensitive water channel MIWC/AQP-4.

21 January 2018

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Aquaporins: important but elusive drug targets.

21 January 2018

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Experimental Evaluation of Proposed Small-Molecule Inhibitors of Water Channel Aquaporin-1

21 January 2018

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Quaternary ammonium compounds as water channel blockers. Specificity, potency, and site of action

21 January 2018

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Identification of arylsulfonamides as Aquaporin 4 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/14728222.2017.1398236

Inhibition of aquaporin-1 and aquaporin-4 water permeability by a derivative of the loop diuretic bumetanide acting at an internal pore-occluding binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/14728222.2017.1398236

Inhibition of aquaporin 4 by antiepileptic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/14728222.2017.1398236

Automated cell-based assay for screening of aquaporin inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/14728222.2017.1398236

Identification of aquaporin 4 inhibitors using in vitro and in silico methods

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/14728222.2017.1398236

Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/14728222.2017.1398236

Inhibition of IkappaB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/14728222.2017.1398236

Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/14728222.2017.1398236

Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/14728222.2017.1398236

Aquaporin 4 and neuromyelitis optica

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/14728222.2017.1398236

Small-molecule inhibitors of NMO-IgG binding to aquaporin-4 reduce astrocyte cytotoxicity in neuromyelitis optica.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/14728222.2017.1398236

Challenging AQP4 druggability for NMO-IgG antibody binding using molecular dynamics and molecular interaction fields

21 January 2018

1 reference

https://api.crossref.org/works/10.1080/14728222.2017.1398236

Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues

21 January 2018

1 reference

12 December 2020

Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues

1 reference

12 December 2020

The mercurial insensitive water channel (AQP-4) forms orthogonal arrays in stably transfected Chinese hamster ovary cells

1 reference

12 December 2020

Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain.

1 reference

12 December 2020

Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4

1 reference

12 December 2020

Mildly abnormal retinal function in transgenic mice without Müller cell aquaporin-4 water channels

1 reference

12 December 2020

Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema.

1 reference

12 December 2020

Protective role of aquaporin-4 water channels after contusion spinal cord injury

1 reference

12 December 2020

Role of aquaporin-4 in the regulation of migration and invasion of human glioma cells

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12 December 2020

Impact of aquaporin‐4 channels on K buffering and gap junction coupling in the hippocampus

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12 December 2020

Three-dimensional organ scanning reveals brain edema reduction in a rat model of stroke treated with an aquaporin 4 inhibitor

1 reference

12 December 2020

10.1080/14728222.2017.1398236

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29072508 AND SRC:MED&resulttype=core&format=json

8 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29072508 AND SRC:MED&resulttype=core&format=json

8 April 2020

PubMed publication ID

29072508

1 reference