Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 alpha-deficient mouse embryonic fibroblasts (Q46325555)

21 December 2017

title

Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 alpha-deficient mouse embryonic fibroblasts (English)

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21 December 2017

Daniel P Stiehl

5

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author name string

Renato Wirthner

1

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21 December 2017

Simon Wrann

2

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21 December 2017

Kuppusamy Balamurugan

3

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21 December 2017

Roland H Wenger

4

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21 December 2017

language of work or name

English

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publication date

8 October 2008

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21 December 2017

published in

Carcinogenesis

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21 December 2017

volume

29

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21 December 2017

issue

12

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21 December 2017

page(s)

2306-2316

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21 December 2017

Exploiting tumour hypoxia in cancer treatment

cites work

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Cellular adaptation to hypoxia: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Oxygen sensing by HIF hydroxylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Integration of oxygen signaling at the consensus HRE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

HIF-1 and tumour radiosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Knockdown of hypoxia-inducible factor-1alpha in breast carcinoma MCF-7 cells results in reduced tumor growth and increased sensitivity to methotrexate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Hypoxia-inducible factor-1 inhibition in combination with temozolomide treatment exhibits robust antitumor efficacy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Preconditioning of the tumor vasculature and tumor cells by intermittent hypoxia: implications for anticancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Induction of hypoxia-inducible factor-1alpha overexpression by cobalt chloride enhances cellular resistance to photodynamic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

A simple technique for quantitation of low levels of DNA damage in individual cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Mitochondrial reactive oxygen species control the transcription factor CHOP-10/GADD153 and adipocyte differentiation: a mechanism for hypoxia-dependent effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

The Promoters for Human DNA-PKcs(PRKDC) andMCM4:Divergently Transcribed Genes Located at Chromosome 8 Band q11

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Mouse cdc21 only 0.5 kb upstream from dna-pkcs in a head-to-head organization: an implication of co-evolution of ATM family members and cell cycle regulating genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Differential etoposide sensitivity of cells deficient in the Ku and DNA- PKcs components of the DNA-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Molecular and biochemical characterization of xrs mutants defective in Ku80.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Nitric oxide upregulates expression of DNA-PKcs to protect cells from DNA-damaging anti-tumour agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

HIF1alpha delays premature senescence through the activation of MIF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

HIF-2alpha specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Hypoxia-induced genetic instability--a calculated mechanism underlying tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

Hypoxia-Inducible Factor-1 Expression Predicts a Poor Response to Primary Chemoendocrine Therapy and Disease-Free Survival in Primary Human Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/CARCIN/BGN231

21 January 2018

Identifiers

DOI

10.1093/CARCIN/BGN231

1 reference

21 December 2017

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21 December 2017