The NAD -dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes (Q46295983)

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English	The NAD -dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/28973648

The NAD -dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes (English)

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/28973648

10

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1 June 2020

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1 June 2020

Elisabete Ramos

5

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1 June 2020

Claudia Cavadas

8

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1 June 2020

Tiago Fleming Outeiro

11

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1 June 2020

12

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1 June 2020

author name string

Vera Lemos

1

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1 June 2020

Éva Szegö

4

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1 June 2020

Sónia Pinho

6

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1 June 2020

Fernando Magro

7

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1 June 2020

A Cristina Rego

9

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1 June 2020

Rita M de Oliveira

2

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1 June 2020

publication date

26 July 2017

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PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/28973648

Human Molecular Genetics

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1 June 2020

26

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1 June 2020

21

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1 June 2020

4105-4117

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1 June 2020

Hepatic glucose metabolism in humans--its role in health and disease

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Mechanisms of obesity-associated insulin resistance: many choices on the menu

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Role of mitochondrial dysfunction in insulin resistance

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Reactive oxygen species have a causal role in multiple forms of insulin resistance

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Aging and disease: connections to sirtuins

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Mammalian sirtuins: biological insights and disease relevance

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Sirtuins mediate mammalian metabolic responses to nutrient availability

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Are sirtuins viable targets for improving healthspan and lifespan?

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Sirt2 suppresses inflammatory responses in collagen-induced arthritis

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation.

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Emerging Role of Sirtuin 2 in the Regulation of Mammalian Metabolism

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Sirtuin gene expression in human mononuclear cells is modulated by caloric restriction.

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD system.

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Sirt2 deacetylase is a novel AKT binding partner critical for AKT activation by insulin

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3β/β-catenin signaling

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Mouse models of the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Increased oxidative stress in obesity and its impact on metabolic syndrome

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Downregulation of miR-181a upregulates sirtuin-1 (SIRT1) and improves hepatic insulin sensitivity

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver.

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Assessing mitochondrial dysfunction in cells.

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity.

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Mitochondrial dynamics as a bridge between mitochondrial dysfunction and insulin resistance

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis.

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

From mice to men: insights into the insulin resistance syndromes

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Peripheral blood mononuclear cells: a potential source of homeostatic imbalance markers associated with obesity development

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction

1 reference

https://api.crossref.org/works/10.1093/HMG/DDX298

21 January 2018

Identifiers

10.1093/HMG/DDX298

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28973648 AND SRC:MED&resulttype=core&format=json

1 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28973648 AND SRC:MED&resulttype=core&format=json

1 June 2020

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