Oxidative stress and cellular pathologies in Parkinson's disease. (Q46252606)

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4 April 2020

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8 October 2022

Oxidative stress and cellular pathologies in Parkinson's disease (English)

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Lesly Puspita

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1

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Sun Young Chung

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28 November 2017

3 references

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8 October 2022

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25 April 2019

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8 October 2022

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Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease

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α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease

24 May 2018

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DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease

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Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription

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24 May 2018

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24 May 2018

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24 May 2018

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PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

24 May 2018

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24 May 2018

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24 May 2018

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24 May 2018

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Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation

24 May 2018

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LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress

24 May 2018

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Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA

24 May 2018

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Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

24 May 2018

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24 May 2018

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24 May 2018

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Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function

24 May 2018

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24 May 2018

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

24 May 2018

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Alpha-Synuclein conformation affects its tyrosine-dependent oxidative aggregation

24 May 2018

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24 May 2018

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24 May 2018

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24 May 2018

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24 May 2018

1 reference

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24 May 2018

1 reference

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24 May 2018

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Oxidative damage in nucleic acids and Parkinson's disease.

24 May 2018

1 reference

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Effect of 4-hydroxy-2-nonenal modification on alpha-synuclein aggregation

24 May 2018

1 reference

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

24 May 2018

1 reference

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24 May 2018

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Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization

24 May 2018

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Dopamine covalently modifies and functionally inactivates parkin

24 May 2018

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A common LRRK2 mutation in idiopathic Parkinson's disease

24 May 2018

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The major target of the endogenously generated reactive oxygen species in response to insulin stimulation is phosphatase and tensin homolog and not phosphoinositide-3 kinase (PI-3 kinase) in the PI-3 kinase/Akt pathway

24 May 2018

1 reference

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Mechanisms of chaperone-mediated autophagy

24 May 2018

1 reference

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The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

24 May 2018

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

24 May 2018

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Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

24 May 2018

1 reference

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Coupling endoplasmic reticulum stress to the cell death program

24 May 2018

1 reference

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Mitochondrial dysfunction and reactive oxygen species in excitotoxicity and apoptosis: implications for the pathogenesis of neurodegenerative diseases

24 May 2018

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Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease

24 May 2018

1 reference

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Quantitating protein synthesis, degradation, and endogenous antigen processing

24 May 2018

1 reference

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

24 May 2018

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Production of reactive oxygen species from aggregating proteins implicated in Alzheimer's disease, Parkinson's disease and other neurodegenerative diseases

24 May 2018

1 reference

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Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

24 May 2018

1 reference

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Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

24 May 2018

1 reference

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

24 May 2018

1 reference

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Mitochondrial free radical generation, oxidative stress, and aging

24 May 2018

1 reference

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Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

24 May 2018

1 reference

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Role of cytochrome c as a stimulator of alpha-synuclein aggregation in Lewy body disease

24 May 2018

1 reference

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Dopamine quinone formation and protein modification associated with the striatal neurotoxicity of methamphetamine: evidence against a role for extracellular dopamine.

24 May 2018

1 reference

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Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum

24 May 2018

1 reference

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

24 May 2018

1 reference

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Increased Protein Oxidation in Human Substantia Nigra Pars Compacta in Comparison with Basal Ganglia and Prefrontal Cortex Measured with an Improved Dinitrophenylhydrazine Assay

24 May 2018

1 reference

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α-Synuclein in Lewy bodies

24 May 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

24 May 2018

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Role of oxidation in the neurotoxic effects of intrastriatal dopamine injections

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Normal oxidative damage to mitochondrial and nuclear DNA is extensive

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Increased nigral iron content in postmortem parkinsonian brain

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Mitochondrial complex I deficiency in Parkinson's disease

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Potential oxidative pathways of brain catecholamines

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons

24 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

ER Stress Induced by Tunicamycin Triggers α-Synuclein Oligomerization, Dopaminergic Neurons Death and Locomotor Impairment: a New Model of Parkinson's Disease.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Highly specific changes in antioxidant levels and lipid peroxidation in Parkinson's disease and its progression: Disease and staging biomarkers and new drug targets.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Dopamine induces mitochondrial depolarization without activating PINK1-mediated mitophagy.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Generation of ferric iron links oxidative stress to α-synuclein oligomer formation

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Modulation of ER stress and apoptosis by endoplasmic reticulum calcium leak via translocon during unfolded protein response: involvement of GRP78.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

RESP18 is involved in the cytotoxicity of dopaminergic neurotoxins in MN9D cells

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Dopamine quinones interact with alpha-synuclein to form unstructured adducts.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

The mechanism of mitochondrial superoxide production by the cytochrome bc1 complex

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Activation of the unfolded protein response in Parkinson's disease

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Inhibition of rat brain mitochondrial electron transport chain activity by dopamine oxidation products during extended in vitro incubation: implications for Parkinson's disease.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Ribosome-translocon complex mediates calcium leakage from endoplasmic reticulum stores

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion on activities of the enzymes in the electron transport system in mouse brain

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5706368

An iron–dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta

15 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186/S13041-017-0340-9

A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186/S13041-017-0340-9

Superoxide radicals as precursors of mitochondrial hydrogen peroxide

21 January 2018

1 reference

12 December 2020

Occupational exposure to manganese, copper, lead, iron, mercury and zinc and the risk of Parkinson's disease.

1 reference

12 December 2020

Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death

1 reference

12 December 2020

Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease

1 reference

12 December 2020

10.1186/S13041-017-0340-9

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29183391 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

4 April 2020

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s13041-017-0340-9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29183391 AND SRC:MED&resulttype=core&format=json

4 April 2020

PubMed publication ID

29183391

1 reference