Randomized, double-blind, placebo-controlled, dose-escalation study: Investigation of the safety, pharmacokinetics, and antihyperalgesic activity of l-4-chlorokynurenine in healthy volunteers (Q46242157)

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scientific article published on 15 June 2017

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English	Randomized, double-blind, placebo-controlled, dose-escalation study: Investigation of the safety, pharmacokinetics, and antihyperalgesic activity of l-4-chlorokynurenine in healthy volunteers	scientific article published on 15 June 2017

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/29229209

Randomized, double-blind, placebo-controlled, dose-escalation study: Investigation of the safety, pharmacokinetics, and antihyperalgesic activity of l-4-chlorokynurenine in healthy volunteers (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/29229209

pharmacokinetics

1 reference

based on heuristic

inferred from title

author name string

Mark Wallace

1

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/29229209

Alexander White

2

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/29229209

Kathy A Grako

3

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/29229209

Randal Lane

4

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/29229209

Allen Jo Cato

5

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/29229209

H Ralph Snodgrass

6

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/29229209

publication date

15 June 2017

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/29229209

Scandinavian Journal of Pain

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/29229209

17

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/29229209

243-251

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/29229209

Future treatment strategies for neuropathic pain.

1 reference

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Ketamine for chronic pain: risks and benefits

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Pharmacokinetic and pharmacodynamic considerations for NMDA receptor antagonists in the treatment of chronic neuropathic pain

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Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition

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Effects of intrathecal NMDA and non-NMDA antagonists on acute thermal nociception and their interaction with morphine

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Clinical experience with excitatory amino acid antagonist drugs

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The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential

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7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex

1 reference

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21 January 2018

Indole-2-carboxylates, novel antagonists of the N-methyl-D-aspartate (NMDA)-associated glycine recognition sites: in vivo characterization

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Enzyme-activated antagonists of the strychnine-insensitive glycine/NMDA receptor

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Excitotoxic injury stimulates pro-drug-induced 7-chlorokynurenate formation in the rat striatum in vivo

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Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease

1 reference

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21 January 2018

Chronic neuroleptic treatment reduces endogenous kynurenic acid levels in rat brain

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21 January 2018

Central proinflammatory cytokines and pain enhancement

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21 January 2018

Kynurenines in CNS disease: regulation by inflammatory cytokines

1 reference

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21 January 2018

Characterization of the Effects of L-4-Chlorokynurenine on Nociception in Rodents.

1 reference

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21 January 2018

A new human experimental pain model: the heat/capsaicin sensitization model

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21 January 2018

The heat/capsaicin sensitization model: A methodologic study

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21 January 2018

Human experimental pain models for assessing the therapeutic efficacy of analgesic drugs

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21 January 2018

Structure and function of TRPV1.

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21 January 2018

Effect of morphine and pregabalin compared with diphenhydramine hydrochloride and placebo on hyperalgesia and allodynia induced by intradermal capsaicin in healthy male subjects

1 reference

https://api.crossref.org/works/10.1016/J.SJPAIN.2017.05.004

21 January 2018

Differential effects of systemically administered ketamine and lidocaine on dynamic and static hyperalgesia induced by intradermal capsaicin in humans

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21 January 2018

Concentration-effect relationships for intravenous alfentanil and ketamine infusions in human volunteers: effects on acute thresholds and capsaicin-evoked hyperpathia

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Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers.

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21 January 2018

Chronic oral gabapentin reduces elements of central sensitization in human experimental hyperalgesia

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21 January 2018

The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition.

1 reference

https://api.crossref.org/works/10.1016/J.SJPAIN.2017.05.004

21 January 2018

Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain

1 reference

https://api.crossref.org/works/10.1016/J.SJPAIN.2017.05.004

21 January 2018

L-4-chlorokynurenine attenuates kainate-induced seizures and lesions in the rat.

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21 January 2018

A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic pain

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21 January 2018

Alfentanil, but not amitriptyline, reduces pain, hyperalgesia, and allodynia from intradermal injection of capsaicin in humans

1 reference

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A Randomized, Double-Blind, Placebo-Controlled, Crossover Study of the T-Type Calcium Channel Blocker ABT-639 in an Intradermal Capsaicin Experimental Pain Model in Healthy Adults

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T-type calcium channels mediate the transition between tonic and phasic firing in thalamic neurons

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Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial

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Identifiers

10.1016/J.SJPAIN.2017.05.004

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/29229209

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/29229209

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