PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage (Q46241095)

20 December 2017

title

PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage (English)

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20 December 2017

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9

B A Hemmings

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20 December 2017

author name string

E Gresko

1

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20 December 2017

S Ritterhoff

2

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20 December 2017

J Sevilla-Perez

3

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20 December 2017

A Roscic

4

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20 December 2017

K Fröbius

5

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20 December 2017

I Kotevic

6

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20 December 2017

A Vichalkovski

7

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D Hess

8

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M L Schmitz

10

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20 December 2017

language of work or name

English

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publication date

17 November 2008

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20 December 2017

published in

Oncogene

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20 December 2017

volume

28

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20 December 2017

issue

5

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20 December 2017

page(s)

698-708

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20 December 2017

Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

cites work

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PML regulates p53 stability by sequestering Mdm2 to the nucleolus

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Deconstructing PML-induced premature senescence

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Promyelocytic leukemia (PML) nuclear bodies are protein structures that do not accumulate RNA

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Pondering the puzzle of PML (promyelocytic leukemia) nuclear bodies: can we fit the pieces together using an RNA regulon?

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HIPK2: a versatile switchboard regulating the transcription machinery and cell death

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Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

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Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM.

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PML is a direct p53 target that modulates p53 effector functions

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The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

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PML nuclear bodies: dynamic sensors of DNA damage and cellular stress

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Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR.

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HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function

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Regulation of p53 activity in nuclear bodies by a specific PML isoform

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Autoregulatory control of the p53 response by caspase-mediated processing of HIPK2.

21 January 2018

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Phosphorylation of PML by mitogen-activated protein kinases plays a key role in arsenic trioxide-mediated apoptosis

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Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

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PML targeting eradicates quiescent leukaemia-initiating cells

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Covalent modification of PML by the sentrin family of ubiquitin-like proteins

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Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha

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Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway

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Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription

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A collective form of cell death requires homeodomain interacting protein kinase

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Review: properties and assembly mechanisms of ND10, PML bodies, or PODs

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Probability-based protein identification by searching sequence databases using mass spectrometry data

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Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells

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HIPK2: a multitalented partner for transcription factors in DNA damage response and development.

21 January 2018

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Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2.

21 January 2018

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A CK2-dependent mechanism for degradation of the PML tumor suppressor

21 January 2018

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The mechanisms of PML-nuclear body formation

21 January 2018

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Phosphorylation of PML is essential for activation of C/EBP epsilon and PU.1 to accelerate granulocytic differentiation

21 January 2018

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PML nuclear bodies and apoptosis

21 January 2018

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RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

21 January 2018

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Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

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Acute promyelocytic leukemia: from highly fatal to highly curable

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HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis

21 January 2018

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PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2

21 January 2018

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Peters Plus syndrome is a new congenital disorder of glycosylation and involves defective Omicron-glycosylation of thrombospondin type 1 repeats

21 January 2018

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31 March 2020

Identifiers

DOI

10.1038/ONC.2008.420

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20 December 2017

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20 December 2017