Dissecting the conserved NPxxY motif of the M3 muscarinic acetylcholine receptor: critical role of Asp-7.49 for receptor signaling and multiprotein complex formation. (Q46213205)

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English	Dissecting the conserved NPxxY motif of the M3 muscarinic acetylcholine receptor: critical role of Asp-7.49 for receptor signaling and multiprotein complex formation.	scientific article

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18 January 2020

Dissecting the conserved NPxxY motif of the M3 muscarinic acetylcholine receptor: critical role of Asp-7.49 for receptor signaling and multiprotein complex formation (English)

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18 January 2020

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18 January 2020

Dasiel Oscar Borroto Escuela

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18 January 2020

Patrícia A Correia

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18 January 2020

Pere Garriga Sole

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Francisco Ciruela

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Francisco Ciruela

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18 January 2020

Wilber Romero-Fernandez

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Wilber Romero-Fernandez

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18 January 2020

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Gloria García-Negredo

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18 January 2020

Pere Garriga

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18 January 2020

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15 December 2011

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18 January 2020

Cellular Physiology and Biochemistry

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18 January 2020

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18 January 2020

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18 January 2020

1009-1022

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18 January 2020

Muscarinic receptor subtypes in neuronal and non-neuronal cholinergic function

1 reference

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21 January 2018

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1 reference

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Amino acid side chains that define muscarinic receptor/G-protein coupling. Studies of the third intracellular loop

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Molecular mechanisms involved in muscarinic acetylcholine receptor-mediated G protein activation studied by insertion mutagenesis

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Structural basis of receptor/G protein coupling selectivity studied with muscarinic receptors as model systems

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A single amino acid substitution (N297A) in the conserved NPXXY sequence of the human N-formyl peptide receptor results in inhibition of desensitization and endocytosis, and a dose-dependent shift in p42/44 mitogen-activated protein kinase activatio

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21 January 2018

Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation

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Mutation of tyrosine in the conserved NPXXY sequence leads to constitutive phosphorylation and internalization, but not signaling, of the human B2 bradykinin receptor

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A proposed structure for transmembrane segment 7 of G protein-coupled receptors incorporating an asn-Pro/Asp-Pro motif

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Rhodopsin-family receptors associate with small G proteins to activate phospholipase D.

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ADP-ribosylation factor-dependent phospholipase D activation by the M3 muscarinic receptor

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Evidence for ADP-ribosylation-factor-mediated activation of phospholipase D by m3 muscarinic acetylcholine receptor

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Rapid and persistent desensitization of m3 muscarinic acetylcholine receptor-stimulated phospholipase D. Concomitant sensitization of phospholipase C.

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Muscarinic receptors--characterization, coupling and function

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Regulation of phospholipase C and D activities by small molecular weight G proteins and muscarinic receptors

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Mechanisms of regulation of phospholipase D1 and D2 by the heterotrimeric G proteins G13 and Gq.

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The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq-type G proteins: regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling

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21 January 2018

The paired activation of the two components of the muscarinic M3 receptor dimer is required for induction of ERK1/2 phosphorylation

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21 January 2018

Phospholipase C{beta}3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain

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Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain

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C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins

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Adhesion-dependent redistribution of MAP kinase and MEK promotes muscarinic receptor-mediated signaling to the nucleus

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Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function

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An activation switch in the rhodopsin family of G protein-coupled receptors: the thyrotropin receptor

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Muscarinic M3 receptor coupling and regulation

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Selective Interaction of ARF1 with the Carboxy-Terminal Tail Domain of the 5-HT2A Receptor

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