Single-molecule assays for investigating protein misfolding and aggregation (Q46164744)

20 December 2017

title

Single-molecule assays for investigating protein misfolding and aggregation (English)

1 reference

20 December 2017

author name string

Armin Hoffmann

series ordinal

1

1 reference

20 December 2017

Krishna Neupane

series ordinal

2

1 reference

20 December 2017

Michael T Woodside

series ordinal

3

1 reference

20 December 2017

language of work or name

English

0 references

publication date

23 April 2013

1 reference

20 December 2017

Physical Chemistry Chemical Physics

published in

1 reference

20 December 2017

volume

15

1 reference

20 December 2017

issue

21

1 reference

20 December 2017

page(s)

7934-7948

1 reference

20 December 2017

Principles of protein folding, misfolding and aggregation

cites work

1 reference

Folding and association versus misfolding and aggregation of proteins

21 January 2018

1 reference

Prevention of amyloid-like aggregation as a driving force of protein evolution.

21 January 2018

1 reference

21 January 2018

Co-translational folding

1 reference

Molecular chaperones in protein folding and proteostasis

21 January 2018

1 reference

Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

1 reference

Cellular strategies for controlling protein aggregation

21 January 2018

1 reference

Protein drug stability: a formulation challenge

21 January 2018

1 reference

Protein aggregation and its inhibition in biopharmaceutics

21 January 2018

1 reference

Insulin analogues and their potential in the management of diabetes mellitus

21 January 2018

1 reference

Structure of the cross-beta spine of amyloid-like fibrils

21 January 2018

1 reference

Protein misfolding, functional amyloid, and human disease

21 January 2018

1 reference

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

21 January 2018

1 reference

Structural classification of toxic amyloid oligomers

21 January 2018

1 reference

Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils

21 January 2018

1 reference

Functional amyloid--from bacteria to humans.

21 January 2018

1 reference

A diversity of assembly mechanisms of a generic amyloid fold

21 January 2018

1 reference

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

21 January 2018

1 reference

Quantitative and spatio-temporal features of protein aggregation in Escherichia coli and consequences on protein quality control and cellular ageing

21 January 2018

1 reference

The propagation of prion-like protein inclusions in neurodegenerative diseases

21 January 2018

1 reference

Transmission of prions within the gut and towards the central nervous system

21 January 2018

1 reference

The transcellular spread of cytosolic amyloids, prions, and prionoids

21 January 2018

1 reference

Intermolecular transmission of superoxide dismutase 1 misfolding in living cells

21 January 2018

1 reference

Purified and synthetic Alzheimer's amyloid beta (Aβ) prions

21 January 2018

1 reference

Non-native protein aggregation kinetics

21 January 2018

1 reference

Protein aggregation kinetics, mechanism, and curve-fitting: a review of the literature.

21 January 2018

1 reference

Polymorphism in the intermediates and products of amyloid assembly

21 January 2018

1 reference

For protein misassembly, it's the "I" decade

21 January 2018

1 reference

Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

21 January 2018

1 reference

The presence of valine at residue 129 in human prion protein accelerates amyloid formation.

21 January 2018

1 reference

Phosphorylation as a tool to modulate aggregation propensity and to predict fibril architecture

21 January 2018

1 reference

The osmophobic effect: natural selection of a thermodynamic force in protein folding

21 January 2018

1 reference

Macromolecular crowding and confinement: biochemical, biophysical, and potential physiological consequences

21 January 2018

1 reference

Molecular level insight into intra-solvent interaction effects on protein stability and aggregation.

21 January 2018

1 reference

Experimental investigation of protein folding and misfolding

21 January 2018

1 reference

Techniques to study amyloid fibril formation in vitro

21 January 2018

1 reference

Assays for α-synuclein aggregation

21 January 2018

1 reference

Techniques for Monitoring Protein Misfolding and Aggregation in Vitro and in Living Cells

21 January 2018

1 reference

Single-molecule studies of protein folding.

21 January 2018

1 reference

Protein folding at single-molecule resolution

21 January 2018

1 reference

Illuminating single molecules in condensed matter

21 January 2018

1 reference

Fluorescence spectroscopy of single molecules under ambient conditions: methodology and technology

21 January 2018

1 reference

A practical guide to single-molecule FRET

21 January 2018

1 reference

The physics of life: one molecule at a time

21 January 2018

1 reference

Surfaces and orientations: much to FRET about?

21 January 2018

1 reference

Experimental determination of upper bound for transition path times in protein folding from single-molecule photon-by-photon trajectories

21 January 2018

1 reference

Suppressing Brownian motion of individual biomolecules in solution

21 January 2018

1 reference

Development of a technique for the investigation of folding dynamics of single proteins for extended time periods

21 January 2018

1 reference

Quantifying heterogeneity and conformational dynamics from single molecule FRET of diffusing molecules: recurrence analysis of single particles (RASP).

21 January 2018

1 reference

Recent advances in single‐molecule detection on micro‐ and nano‐fluidic devices

21 January 2018

1 reference

Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing.

21 January 2018

1 reference

Protein folding studied by single-molecule FRET.

21 January 2018

1 reference

Function and dysfunction of α-synuclein: probing conformational changes and aggregation by single molecule fluorescence

21 January 2018

1 reference

Single-molecule approaches to prion protein misfolding

21 January 2018

1 reference

Fluorescence correlation spectroscopy: novel variations of an established technique

21 January 2018

1 reference

Rapid acquisition of beta-sheet structure in the prion protein prior to multimer formation

21 January 2018

1 reference

Amyloid beta-peptide polymerization studied using fluorescence correlation spectroscopy

21 January 2018

1 reference

The amyloid beta peptide (Abeta(1-40)) is thermodynamically soluble at physiological concentrations

21 January 2018

1 reference

Measuring Size Distribution in Highly Heterogeneous Systems with Fluorescence Correlation Spectroscopy

21 January 2018

1 reference

Measurement of the attachment and assembly of small amyloid-β oligomers on live cell membranes at physiological concentrations using single-molecule tools.

21 January 2018

1 reference

Early aggregation steps in alpha-synuclein as measured by FCS and FRET: evidence for a contagious conformational change.

21 January 2018

1 reference

Art and artefacts of fluorescence correlation spectroscopy.

21 January 2018

1 reference

Resolution of fluorescence correlation measurements

21 January 2018

1 reference

Two-focus fluorescence correlation spectroscopy: a new tool for accurate and absolute diffusion measurements

21 January 2018

1 reference

Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy

21 January 2018

1 reference

Ultrasensitive detection of pathological prion protein aggregates by dual-color scanning for intensely fluorescent targets

21 January 2018

1 reference

Detection of prion particles in samples of BSE and scrapie by fluorescence correlation spectroscopy without proteinase K digestion

21 January 2018

1 reference

Single particle analysis of manganese-induced prion protein aggregates

21 January 2018

1 reference

Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers

21 January 2018

1 reference

Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron

21 January 2018

1 reference

Two different binding modes of α-synuclein to lipid vesicles depending on its aggregation state

21 January 2018

1 reference

Direct characterization of amyloidogenic oligomers by single-molecule fluorescence

21 January 2018

1 reference

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide

21 January 2018

1 reference

Single molecule characterization of α-synuclein in aggregation-prone states

21 January 2018

1 reference

Alteration of the alpha-synuclein folding landscape by a mutation related to Parkinson's disease

21 January 2018

1 reference

Single-molecule fluorescence reveals sequence-specific misfolding in multidomain proteins

21 January 2018

1 reference

Direct observation of the interconversion of normal and toxic forms of α-synuclein

21 January 2018

1 reference

Monitoring the earliest amyloid-beta oligomers via quantized photobleaching of dye-labeled peptides

21 January 2018

1 reference

Determination of the oligomer size of amyloidogenic protein beta-amyloid(1-40) by single-molecule spectroscopy

21 January 2018

1 reference

Protein unfolding and refolding under force: methodologies for nanomechanics

21 January 2018

1 reference

Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy

21 January 2018

1 reference

High-resolution, single-molecule measurements of biomolecular motion

21 January 2018

1 reference

Theory, analysis, and interpretation of single-molecule force spectroscopy experiments

21 January 2018

1 reference

Passive all-optical force clamp for high-resolution laser trapping

21 January 2018

1 reference

Force-clamp spectroscopy monitors the folding trajectory of a single protein

21 January 2018

1 reference

Direct measurement of the full, sequence-dependent folding landscape of a nucleic acid

21 January 2018

1 reference

Full distance-resolved folding energy landscape of one single protein molecule

21 January 2018

1 reference

Energy landscape analysis of native folding of the prion protein yields the diffusion constant, transition path time, and rates

21 January 2018

1 reference

The folding cooperativity of a protein is controlled by its chain topology

21 January 2018

1 reference

Protein-DNA chimeras for single molecule mechanical folding studies with the optical tweezers

21 January 2018

1 reference

Observing folding pathways and kinetics of a single sodium-proton antiporter from Escherichia coli.

21 January 2018

1 reference

Conformational equilibria in monomeric alpha-synuclein at the single-molecule level

21 January 2018

1 reference

Pathogenic mutations shift the equilibria of alpha-synuclein single molecules towards structured conformers

21 January 2018

1 reference

The complex folding network of single calmodulin molecules

21 January 2018

1 reference

Single-molecule observation of helix staggering, sliding, and coiled coil misfolding

21 January 2018

1 reference

Direct observation of multiple misfolding pathways in a single prion protein molecule

21 January 2018

1 reference

Signal‐Pair Correlation Analysis of Single‐Molecule Trajectories

21 January 2018

1 reference

alpha-Synuclein misfolding: single molecule AFM force spectroscopy study

21 January 2018

1 reference

Effect of spermidine on misfolding and interactions of alpha-synuclein

21 January 2018

1 reference

Single-Molecule Atomic Force Microscopy Force Spectroscopy Study of Aβ-40 Interactions

21 January 2018

1 reference

Effect of electrostatics on aggregation of prion protein Sup35 peptide

21 January 2018

1 reference

Dynamic strength of molecular adhesion bonds

21 January 2018

1 reference

Tandem repeating modular proteins avoid aggregation in single molecule force spectroscopy experiments

21 January 2018

1 reference

Spectrin domains lose cooperativity in forced unfolding

21 January 2018

1 reference

Tracking UNC-45 chaperone-myosin interaction with a titin mechanical reporter.

21 January 2018

1 reference

Protein folding drives disulfide formation

21 January 2018

1 reference

Direct observation of chaperone-induced changes in a protein folding pathway

21 January 2018

1 reference

Probing the mechanism of amyloidogenesis through a tandem repeat of the PI3-SH3 domain suggests a generic model for protein aggregation and fibril formation

21 January 2018

1 reference

In vitro and in vivo neurotoxicity of prion protein oligomers.

21 January 2018

1 reference

Nanomechanical properties of single amyloid fibrils

21 January 2018

1 reference

Nanomechanical properties of human prion protein amyloid as probed by force spectroscopy

21 January 2018

1 reference

Mechanical manipulation of Alzheimer's amyloid beta1-42 fibrils.

21 January 2018

1 reference

Optical trapping with high forces reveals unexpected behaviors of prion fibrils

21 January 2018

1 reference

Physical Properties of Polymorphic Yeast Prion Amyloid Fibers

21 January 2018

1 reference

Nanomaterials: amyloids reflect their brighter side

21 January 2018

1 reference

Nanopore analysis: An emerging technique for studying the folding and misfolding of proteins

21 January 2018

1 reference

21 January 2018

Solid-state nanopores

1 reference

Nanopore analysis of β-amyloid peptide aggregation transition induced by small molecules.

21 January 2018

1 reference

Controlling protein translocation through nanopores with bio-inspired fluid walls.

21 January 2018

1 reference

Single-particle characterization of Aβ oligomers in solution

21 January 2018

1 reference

Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes

21 January 2018

1 reference

Microsecond folding experiments and simulations: a match is made

21 January 2018

1 reference

The conformational ensembles of α-synuclein and tau: combining single-molecule FRET and simulations

21 January 2018

1 reference

Single particle detection of Aβ aggregates associated with Alzheimer’s disease

21 January 2018

1 reference

AFM-based force spectroscopy measurements of mature amyloid fibrils of the peptide glucagon

21 January 2018

1 reference

Information Content in Fluorescence Correlation Spectroscopy: Binary Mixtures and Detection Volume Distortion

21 January 2018

1 reference

Horizontal prion transmission in mule deer

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1039/C3CP44564J

1 reference

20 December 2017

1 reference

20 December 2017