Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate. (Q45964059)

18 December 2017

title

Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole-imidazole polyamide conjugate. (English)

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18 December 2017

Hiroyuki Yoda

6

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author name string

Kiriko Hiraoka

1

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18 December 2017

Takahiro Inoue

2

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Rhys Dylan Taylor

3

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18 December 2017

Takayoshi Watanabe

4

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Nobuko Koshikawa

5

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Ken-ichi Shinohara

7

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Atsushi Takatori

8

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18 December 2017

Hirokazu Sugimoto

9

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Yoshiaki Maru

10

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18 December 2017

Tadamichi Denda

11

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18 December 2017

Kyoko Fujiwara

12

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Allan Balmain

13

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18 December 2017

Toshinori Ozaki

14

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18 December 2017

Toshikazu Bando

15

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Hiroshi Sugiyama

16

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Hiroki Nagase

17

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18 December 2017

language of work or name

English

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publication date

27 April 2015

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18 December 2017

published in

Nature Communications

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18 December 2017

volume

6

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18 December 2017

page(s)

6706

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18 December 2017

A view on EGFR-targeted therapies from the oncogene-addiction perspective.

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Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer

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Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

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Transcriptional inhibition of progressive renal disease by gene silencing pyrrole-imidazole polyamide targeting of the transforming growth factor-β1 promoter

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Inhibition of MMP-9 transcription and suppression of tumor metastasis by pyrrole-imidazole polyamide

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Antitumor activity of a pyrrole-imidazole polyamide

21 January 2018

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Synthesis and biological properties of sequence-specific DNA-alkylating pyrrole-imidazole polyamides

21 January 2018

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Cell-free and cellular activities of a DNA sequence selective hairpin polyamide-CBI conjugate

21 January 2018

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Sequence specific alkylation of DNA by hairpin pyrrole-imidazole polyamide conjugates

21 January 2018

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Sequence-specific DNA alkylation targeting for Kras codon 13 mutation by pyrrole-imidazole polyamide seco-CBI conjugates

21 January 2018

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Senescence in tumours: evidence from mice and humans

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Aging, cellular senescence, and cancer

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Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines

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A multi-scale approach to colorectal cancer: from a biochemical- interaction signaling-network level, to multi-cellular dynamics of malignant transformation. Interplay with mutations and onco-protein inhibitor drugs

21 January 2018

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Efficient DNA alkylation by a pyrrole-imidazole CBI conjugate with an indole linker: sequence-specific alkylation with nine-base-pair recognition.

21 January 2018

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Arresting cancer proliferation by small-molecule gene regulation

21 January 2018

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Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells

21 January 2018

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Cancer drug discovery through collaboration.

21 January 2018

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Tumor xenograft uptake of a pyrrole-imidazole (Py-Im) polyamide varies as a function of cell line grafted

21 January 2018

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Wound healing response is a major contributor to the severity of cutaneous leishmaniasis in the ear model of infection

21 January 2018

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21 January 2018

Identifiers

DOI

10.1038/NCOMMS7706

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18 December 2017

Dimensions Publication ID

ADS bibcode

2015NatCo...6.6706H

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1013991715

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Microsoft Academic ID

2062852255

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18 December 2017