Bisphosphonates modulate vital functions of human osteoblasts and affect their interactions with breast cancer cells. (Q45954915)

18 December 2017

title

Bisphosphonates modulate vital functions of human osteoblasts and affect their interactions with breast cancer cells. (English)

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18 December 2017

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Wilhelm K Aicher

5

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author name string

Tatjana Kaiser

1

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18 December 2017

Ingrid Teufel

2

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18 December 2017

Konstanze Geiger

3

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18 December 2017

Yvonne Vater

4

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18 December 2017

Gerd Klein

6

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18 December 2017

Tanja Fehm

7

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18 December 2017

language of work or name

English

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publication date

27 June 2013

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18 December 2017

Breast Cancer Research and Treatment

published in

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18 December 2017

volume

140

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18 December 2017

issue

1

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18 December 2017

page(s)

35-48

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18 December 2017

Molecular basis of metastasis.

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Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

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Bisphosphonates act on rat bone resorption through the mediation of osteoblasts

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Bisphosphonates induce osteoblasts to secrete an inhibitor of osteoclast-mediated resorption

21 January 2018

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Bisphosphonates influence the proliferation and the maturation of normal human osteoblasts

21 January 2018

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Effects of alendronate on the proliferation and osteogenic differentiation of MG-63 cells

21 January 2018

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Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts.

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Long-term effects of neridronate on human osteoblastic cell cultures.

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The nitrogen-containing bisphosphonate, zoledronic acid, increases mineralisation of human bone-derived cells in vitro.

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Effects of intravenous zoledronic acid once yearly on bone remodeling and bone structure.

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The effect of zoledronic acid incorporated in a poly(D,L-lactide) implant coating on osteoblasts in vitro

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Direct effects of bisphosphonates on breast cancer cells

21 January 2018

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Bisphosphonates induce apoptosis in human breast cancer cell lines

21 January 2018

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Zoledronic acid induces apoptosis and changes the TRAIL/OPG ratio in breast cancer cells.

21 January 2018

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Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid

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Metastasis and bone loss: advancing treatment and prevention.

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CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment

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Role of stromal-derived cytokines and growth factors in bone metastasis

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The Akt inhibitor triciribine sensitizes prostate carcinoma cells to TRAIL-induced apoptosis

21 January 2018

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Mouse macrophages primed with alendronate down-regulate monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha (MIP-1alpha) production in response to Toll-like receptor (TLR) 2 and TLR4 agonist via Smad3 activation

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Osteoblast-secreted factors enhance the expression of dysadherin and CCL2-dependent migration of renal carcinoma cells.

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Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro

21 January 2018

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Rho GTPase signalling pathways in the morphological changes associated with apoptosis.

21 January 2018

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Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells.

21 January 2018

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Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre/osteoclasts

21 January 2018

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CCL2 is a potent regulator of prostate cancer cell migration and proliferation

21 January 2018

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Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion.

21 January 2018

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PAR1-mediated RhoA activation facilitates CCL2-induced chemotaxis in PC-3 cells

21 January 2018

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Metastatic breast cancer induces an osteoblast inflammatory response

21 January 2018

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CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

21 January 2018

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Osteoblast conditioned media contain TGF-beta1 and modulate the migration of prostate tumor cells and their interactions with extracellular matrix components

21 January 2018

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Zoledronic acid blocks the interaction between mesenchymal stem cells and breast cancer cells: implications for adjuvant therapy of breast cancer.

21 January 2018

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Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells

21 January 2018

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Bone metastasis: Osteoblasts affect growth and adhesion regulons in prostate tumor cells and provoke osteomimicry

21 January 2018

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Chemokine (C-C motif) ligand 2 mediates the prometastatic effect of dysadherin in human breast cancer cells

21 January 2018

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10.1007/S10549-013-2613-Z

21 January 2018

Identifiers

DOI

1 reference

18 December 2017

Dimensions Publication ID

1017942033

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1 reference

18 December 2017