Endoglin and activin receptor-like kinase 1 heterozygous mice have a distinct pulmonary and hepatic angiogenic profile and response to anti-VEGF treatment. (Q45901060)

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scientific article published on 24 September 2013

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English	Endoglin and activin receptor-like kinase 1 heterozygous mice have a distinct pulmonary and hepatic angiogenic profile and response to anti-VEGF treatment.	scientific article published on 24 September 2013

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

Endoglin and activin receptor-like kinase 1 heterozygous mice have a distinct pulmonary and hepatic angiogenic profile and response to anti-VEGF treatment. (English)

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

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Daniela S Ardelean

1

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

Mirjana Jerkic

2

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

Melissa Yin

3

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

Madonna Peter

4

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

Bo Ngan

5

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

Robert S Kerbel

6

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

F Stuart Foster

7

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

Michelle Letarte

8

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

publication date

24 September 2013

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

17

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

1

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

129-146

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

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Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex

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Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

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Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction

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Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis

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Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis

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Arteriovenous malformations in mice lacking activin receptor-like kinase-1

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Potential role of modifier genes influencing transforming growth factor-beta1 levels in the development of vascular defects in endoglin heterozygous mice with hereditary hemorrhagic telangiectasia.

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Spontaneous adult-onset pulmonary arterial hypertension attributable to increased endothelial oxidative stress in a murine model of hereditary hemorrhagic telangiectasia

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Pulmonary hypertension in adult Alk1 heterozygous mice due to oxidative stress.

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Mouse model for hereditary hemorrhagic telangiectasia has a generalized vascular abnormality

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Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us.

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Endoglin expression is reduced in normal vessels but still detectable in arteriovenous malformations of patients with hereditary hemorrhagic telangiectasia type 1.

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21 January 2018

VEGF Induces More Severe Cerebrovascular Dysplasia in Endoglin than in Alk1 Mice

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Tumor angiogenesis

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Bevacizumab reverses need for liver transplantation in hereditary hemorrhagic telangiectasia.

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Bevacizumab in hereditary hemorrhagic telangiectasia

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Bevacizumab in patients with hereditary hemorrhagic telangiectasia and severe hepatic vascular malformations and high cardiac output

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Heterogeneity of the angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor

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21 January 2018

Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling

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21 January 2018

Cross-species vascular endothelial growth factor (VEGF)-blocking antibodies completely inhibit the growth of human tumor xenografts and measure the contribution of stromal VEGF.

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Micro-ultrasound for preclinical imaging

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Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization.

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21 January 2018

Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway

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10.1007/S10456-013-9383-4

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/24061911

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