Factors influencing therapeutic efficacy and the host immune response to helper-dependent adenoviral gene therapy in hemophilia A mice (Q45871591)

17 December 2017

title

Factors influencing therapeutic efficacy and the host immune response to helper-dependent adenoviral gene therapy in hemophilia A mice (English)

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17 December 2017

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B D Brown

1

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17 December 2017

C X Shi

2

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F E M Rawle

3

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S Tinlin

4

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A McKinven

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C Hough

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F L Graham

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D Lillicrap

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publication date

1 January 2004

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17 December 2017

Journal of Thrombosis and Haemostasis

published in

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17 December 2017

volume

2

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17 December 2017

issue

1

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17 December 2017

page(s)

111-118

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17 December 2017

Adenovirus-mediated factor VIII gene expression results in attenuated anti-factor VIII-specific immunity in hemophilia A mice compared with factor VIII protein infusion

cites work

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https://api.crossref.org/works/10.1111/J.1538-7836.2004.00552.X

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In vivo evaluation of an adenoviral vector encoding canine factor VIII: high-level, sustained expression in hemophiliac mice.

21 January 2018

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Systemic delivery of an adenoviral vector encoding canine factor VIII results in short-term phenotypic correction, inhibitor development, and biphasic liver toxicity in hemophilia A dogs.

21 January 2018

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A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal

21 January 2018

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Sustained human factor VIII expression in hemophilia A mice following systemic delivery of a gutless adenoviral vector

21 January 2018

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Therapeutic factor VIII levels and negligible toxicity in mouse and dog models of hemophilia A following gene therapy with high-capacity adenoviral vectors

21 January 2018

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https://api.crossref.org/works/10.1111/J.1538-7836.2004.00552.X

The canine factor VIII 3'-untranslated region and a concatemeric hepatocyte nuclear factor 1 regulatory element enhance factor VIII transgene expression in vivo

21 January 2018

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https://api.crossref.org/works/10.1111/J.1538-7836.2004.00552.X

Optimization of the helper-dependent adenovirus system for production and potency in vivo

21 January 2018

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Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administration

21 January 2018

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Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A

21 January 2018

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RNA template-specific polymerase chain reaction (RS-PCR): a novel strategy to reduce dramatically false positives

21 January 2018

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The release of inflammatory cytokines from human peripheral blood mononuclear cells in vitro following exposure to adenovirus variants and capsid

21 January 2018

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Effect of blood collection technique in mice on clinical pathology parameters

21 January 2018

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Self-tolerance: context dependent tuning of T cell antigen recognition

21 January 2018

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Adenovirus-mediated gene transfer: influence of transgene, mouse strain and type of immune response on persistence of transgene expression

21 January 2018

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Variation in adenovirus transgene expression between BALB/c and C57BL/6 mice is associated with differences in interleukin-12 and gamma interferon production and NK cell activation

21 January 2018

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Intravenous administration of an E1/E3-deleted adenoviral vector induces tolerance to factor IX in C57BL/6 mice

21 January 2018

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https://api.crossref.org/works/10.1111/J.1538-7836.2004.00552.X

In vivo dose threshold effect of adenovirus-mediated factor VIII gene therapy in hemophiliac mice

21 January 2018

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Use of a liver-specific promoter reduces immune response to the transgene in adenoviral vectors

21 January 2018

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https://api.crossref.org/works/10.1111/J.1538-7836.2004.00552.X

Humoral immune response in mice against a circulating antigen induced by adenoviral transfer is strictly dependent on expression in antigen-presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111/J.1538-7836.2004.00552.X

10.1111/J.1538-7836.2004.00552.X

21 January 2018

Identifiers

DOI

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17 December 2017

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17 December 2017