DJ-1 and Parkin modulate dopamine-dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice (Q45865989)

17 December 2017

title

DJ-1 and Parkin modulate dopamine-dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice (English)

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17 December 2017

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Jean-Charles Paterna

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17 December 2017

author name string

Andreas Leng

2

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17 December 2017

Elisabeth Weber

3

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17 December 2017

Joram Feldon

4

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17 December 2017

Hansruedi Büeler

5

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17 December 2017

publication date

13 February 2007

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17 December 2017

published in

Molecular Therapy

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17 December 2017

volume

15

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17 December 2017

issue

4

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17 December 2017

page(s)

698-704

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17 December 2017

Molecular pathophysiology of Parkinson's disease

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

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An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

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Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

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Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons

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Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

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Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis.

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Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

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Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

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Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease

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The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease

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7 January 2021

The DJ-1L166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes

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7 January 2021

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

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7 January 2021

The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein

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7 January 2021

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

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7 January 2021

Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease

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7 January 2021

Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress

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7 January 2021

Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction.

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7 January 2021

Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

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Without DJ-1, the D2 receptor doesn't play

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Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

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Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice

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7 January 2021

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

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Parkinson's disease: mechanisms and models

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Transduction profiles of recombinant adeno-associated virus vectors derived from serotypes 2 and 5 in the nigrostriatal system of rats

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7 January 2021

Recombinant adeno-associated virus vector design and gene expression in the mammalian brain

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7 January 2021

Regulation of dopamine transporter function and plasma membrane expression by dopamine, amphetamine, and cocaine

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7 January 2021

Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter

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Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice.

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Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter.

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7 January 2021

Profound neuronal plasticity in response to inactivation of the dopamine transporter

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Regulation of the transcriptional activity of the tyrosine hydroxylase gene by androgen receptor

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7 January 2021

DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor

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7 January 2021

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

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7 January 2021

Parkin suppresses the expression of monoamine oxidases

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7 January 2021

Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter.

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7 January 2021

Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system

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7 January 2021

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease

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7 January 2021

Parkin is protective for substantia nigra dopamine neurons in a tau gene transfer neurodegeneration model

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7 January 2021

Influence of promoter and WHV post-transcriptional regulatory element on AAV-mediated transgene expression in the rat brain

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7 January 2021

Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

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7 January 2021

Quantification of adeno-associated virus particles and empty capsids by optical density measurement

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Effects of blocking the dopamine biosynthesis and of neurotoxic dopamine depletion with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on voluntary wheel running in mice

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7 January 2021

Identifiers

DOI

10.1038/SJ.MT.6300067

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17 December 2017

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17 December 2017