The molecular basis of the host response to lipopolysaccharide (Q45811531)

16 December 2017

title

The molecular basis of the host response to lipopolysaccharide (English)

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16 December 2017

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2

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16 December 2017

Monique Gangloff

series ordinal

3

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16 December 2017

author name string

Clare E Bryant

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1

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16 December 2017

Nicholas J Gay

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4

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16 December 2017

language of work or name

English

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publication date

1 January 2010

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16 December 2017

Nature Reviews Microbiology

published in

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16 December 2017

volume

8

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16 December 2017

issue

1

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16 December 2017

page(s)

8-14

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16 December 2017

Elucidation of the MD-2/TLR4 interface required for signaling by lipid IVa.

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Approaching the asymptote? Evolution and revolution in immunology

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Lipopolysaccharide endotoxins

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Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4.

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Structure and function of lipopolysaccharide binding protein

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CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein

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Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations

31 March 2020

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Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice

31 March 2020

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

31 March 2020

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

31 March 2020

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Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

31 March 2020

1 reference

Pathogen recognition and innate immunity

31 March 2020

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TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

31 March 2020

1 reference

MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

31 March 2020

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Essential role of MD-2 in LPS responsiveness and TLR4 distribution

31 March 2020

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Structure of toll-like receptors

31 March 2020

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Toll-like receptors as molecular switches

31 March 2020

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ML -- a conserved domain involved in innate immunity and lipid metabolism

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MD-2: the Toll 'gatekeeper' in endotoxin signalling

31 March 2020

1 reference

Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition

31 March 2020

1 reference

Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa

31 March 2020

1 reference

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

31 March 2020

1 reference

Structures of the toll-like receptor family and its ligand complexes

31 March 2020

1 reference

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

31 March 2020

1 reference

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

31 March 2020

1 reference

Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin

31 March 2020

1 reference

The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

31 March 2020

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Structure and function of Toll receptors and their ligands

31 March 2020

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The extra domain A of fibronectin activates Toll-like receptor 4.

31 March 2020

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Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

31 March 2020

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Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization

31 March 2020

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Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock

31 March 2020

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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

31 March 2020

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A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins

31 March 2020

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Cell-penetrating TIR BB loop decoy peptides a novel class of TLR signaling inhibitors and a tool to study topology of TIR-TIR interactions

31 March 2020

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Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

31 March 2020

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Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

31 March 2020

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The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

31 March 2020

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31 March 2020

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Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling

31 March 2020

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LPS, TLR4 and infectious disease diversity.

31 March 2020

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Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response

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Sensing gram-negative bacterial lipopolysaccharides: a human disease determinant?

31 March 2020

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Immunomodulatory effects of Pseudomonas aeruginosa quorum sensing small molecule probes on mammalian macrophages

31 March 2020

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House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

31 March 2020

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Inhibition of Fc epsilon RI-mediated mast cell responses by ES-62, a product of parasitic filarial nematodes

31 March 2020

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Identification and characterization of a novel bacterial virulence factor that shares homology with mammalian Toll/interleukin-1 receptor family proteins

31 March 2020

1 reference

Characterization of a TIR-like protein from Paracoccus denitrificans.

31 March 2020

1 reference

Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins

31 March 2020

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Brucella TIR Domain-containing Protein Mimics Properties of the Toll-like Receptor Adaptor Protein TIRAP.

31 March 2020

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Application of beta-lactamase enzyme complementation to the high-throughput screening of toll-like receptor signaling inhibitors

31 March 2020

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TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

31 March 2020

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Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist

31 March 2020

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Phase 2 trial of eritoran tetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis

31 March 2020

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Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4.

31 March 2020

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International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology

31 March 2020

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Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19946286

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Lipopolysaccharide from <I>Rhodobacter sphaeroides</I> is an agonist in equine cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19946286

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19946286

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRMICRO2266

1 reference

16 December 2017

Dimensions Publication ID

1048409786

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1 reference

16 December 2017