High frequency of p16(INK4A) promoter methylation in NRAS-mutated cutaneous melanoma (Q45803765)

16 December 2017

title

High frequency of p16(INK4A) promoter methylation in NRAS-mutated cutaneous melanoma (English)

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16 December 2017

author name string

Anders Jonsson

1

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16 December 2017

Rainer Tuominen

2

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16 December 2017

Eva Grafström

3

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16 December 2017

Johan Hansson

4

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16 December 2017

Suzanne Egyhazi

5

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16 December 2017

language of work or name

English

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publication date

12 August 2010

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16 December 2017

Journal of Investigative Dermatology

published in

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16 December 2017

volume

130

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16 December 2017

issue

12

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16 December 2017

page(s)

2809-2817

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16 December 2017

Malignant melanoma: genetics and therapeutics in the genomic era.

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Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development

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Expression of p16, CD95, CD95L and Helix pomatia agglutinin in relapsing and nonrelapsing very thin melanoma

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Frequent p16-independent inactivation of p14ARF in human melanoma

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p16INK4a expression is frequently decreased and associated with 9p21 loss of heterozygosity in sporadic melanoma

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7 January 2021

Inverse correlation between p16INK4A expression and NF-kappaB activation in melanoma progression

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Expression and localization of mutant p16 proteins in melanocytic lesions from familial melanoma patients

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Biallelic deletions in INK4 in cutaneous melanoma are common and associated with decreased survival

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ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence

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Genetic alterations in signaling pathways in melanoma

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Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

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Ultraviolet radiation and melanoma: a systematic review and analysis of reported sequence variants

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Germline p16 mutations in familial melanoma

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A cell cycle regulator potentially involved in genesis of many tumor types

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Transcription of mouse DNA methyltransferase 1 (Dnmt1) is regulated by both E2F-Rb-HDAC-dependent and -independent pathways

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p16(INK4a) translation suppressed by miR-24

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Tumor suppression by Ink4a-Arf: progress and puzzles

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Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation.

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

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7 January 2021

p16 expression in primary malignant melanoma is associated with prognosis and lymph node status

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

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Screening of germline mutations in the CDKN2A and CDKN2B genes in Swedish families with hereditary cutaneous melanoma

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Reduced expression of p16 and p27 is correlated with tumour progression in cutaneous melanoma

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Functional impairment of p16(INK4A) due to CDKN2A p.Gly23Asp missense mutation.

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7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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7 January 2021

The INK4a/ARF locus and melanoma

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https://api.crossref.org/works/10.1038/JID.2010.216

7 January 2021

Significant impact of promoter hypermethylation and the 540 C>T polymorphism of CDKN2A in cutaneous melanoma of the vertical growth phase

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https://api.crossref.org/works/10.1038/JID.2010.216

7 January 2021

Recurrent patterns of dual RB and p53 pathway inactivation in melanoma

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7 January 2021

Identifiers

DOI

10.1038/JID.2010.216

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16 December 2017

Dimensions Publication ID

1012750944

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16 December 2017