Enhanced antitumor activity mediated by human 4-1BB-engineered T cells (Q45441936)

14 December 2017

title

Enhanced antitumor activity mediated by human 4-1BB-engineered T cells (English)

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14 December 2017

author name string

Inbal Daniel-Meshulam

series ordinal

1

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14 December 2017

Miryam Horovitz-Fried

series ordinal

2

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14 December 2017

Cyrille J Cohen

series ordinal

3

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14 December 2017

language of work or name

English

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publication date

16 July 2013

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International Journal of Cancer

14 December 2017

published in

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14 December 2017

volume

133

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14 December 2017

issue

12

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14 December 2017

page(s)

2903-2913

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Sequence, structure, function, immunity: structural genomics of costimulation.

14 December 2017

cites work

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T‐cell intrinsic effects of GITR and 4‐1BB during viral infection and cancer immunotherapy

21 January 2018

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4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells

21 January 2018

1 reference

Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP.

21 January 2018

1 reference

Tumor Expression of 4-1BB Ligand Sustains Tumor Lytic T Cells

21 January 2018

1 reference

Analysis of CD137 and CD137L expression in human primary tumor tissues

21 January 2018

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Functional dichotomy between OX40 and 4-1BB in modulating effector CD8 T cell responses.

21 January 2018

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4-1BB costimulatory signals preferentially induce CD8 T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses

21 January 2018

1 reference

Costimulation Through the CD137/4-1BB Pathway Protects Human Melanoma Tumor-infiltrating Lymphocytes From Activation-induced Cell Death and Enhances Antitumor Effector Function

21 January 2018

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4-1BB promotes the survival of CD8 T lymphocytes by increasing expression of Bcl-xL and Bfl-1.

21 January 2018

1 reference

Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?

21 January 2018

1 reference

Immunity to melanoma mediated by 4-1BB is associated with enhanced activity of tumour-infiltrating lymphocytes

21 January 2018

1 reference

CD137 agonist antibody prevents cancer recurrence: contribution of CD137 on both hematopoietic and nonhematopoietic cells

21 January 2018

1 reference

Adoptive immunotherapy for cancer: harnessing the T cell response

21 January 2018

1 reference

Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy

21 January 2018

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Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy

21 January 2018

1 reference

Genetically modulating T-cell function to target cancer.

21 January 2018

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Restoration of CD28 expression in CD28- CD8 memory effector T cells reconstitutes antigen-induced IL-2 production

21 January 2018

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T cells expressing constitutively active Akt resist multiple tumor-associated inhibitory mechanisms.

21 January 2018

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Recognition of fresh human tumor by human peripheral blood lymphocytes transduced with a bicistronic retroviral vector encoding a murine anti-p53 TCR.

21 January 2018

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Cancer regression in patients after transfer of genetically engineered lymphocytes

21 January 2018

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Incorporation of transmembrane hydrophobic mutations in the TCR enhance its surface expression and T cell functional avidity.

21 January 2018

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Selected murine residues endow human TCR with enhanced tumor recognition

21 January 2018

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Phenotypic heterogeneity of melanoma. Relation to the differentiation program of melanoma cells

21 January 2018

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Immunotherapy of Cancer with 4-1BB

21 January 2018

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TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

21 January 2018

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Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB.

21 January 2018

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T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection

21 January 2018

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Augmented lymphocyte expansion from solid tumors with engineered cells for costimulatory enhancement

21 January 2018

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IL-15-dependent induction of 4-1BB promotes antigen-independent CD8 memory T cell survival

21 January 2018

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Chimeric receptors containing CD137 signal transduction domains mediate enhanced survival of T cells and increased antileukemic efficacy in vivo

21 January 2018

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4-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity

21 January 2018

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TRANSPLANTABILITY OF TISSUES TO THE EMBRYO OF FOREIGN SPECIES : ITS BEARING ON QUESTIONS OF TISSUE SPECIFICITY AND TUMOR IMMUNITY.

21 January 2018

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Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice

21 January 2018

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Anti-4-1BB monoclonal antibodies abrogate T cell-dependent humoral immune responses in vivo through the induction of helper T cell anergy

21 January 2018

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CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells.

21 January 2018

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Clinical Experiences With Anti-CD137 and Anti-PD1 Therapeutic Antibodies

21 January 2018

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Autoimmunity associated with immunotherapy of cancer

21 January 2018

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A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity

21 January 2018

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Chimeric antigen receptors combining 4-1BB and CD28 signaling domains augment PI3kinase/AKT/Bcl-XL activation and CD8 T cell-mediated tumor eradication

21 January 2018

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Chick embryo chorioallantoic membrane model systems to study and visualize human tumor cell metastasis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.28320

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14 December 2017

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