Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. (Q45300532)

PubMed publication ID

10844007

11 December 2017

title

Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease (English)

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12 May 2020

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2

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12 May 2020

Rima Kaddurah-Daouk

7

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12 May 2020

9

M F Beal

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12 May 2020

author name string

R J Ferrante

1

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12 May 2020

B G Jenkins

3

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12 May 2020

A Dedeoglu

4

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12 May 2020

S Kuemmerle

5

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J K Kubilus

6

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12 May 2020

S M Hersch

8

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language of work or name

English

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publication date

1 June 2000

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PubMed publication ID

10844007

11 December 2017

published in

Journal of Neuroscience

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12 May 2020

volume

20

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12 May 2020

issue

12

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12 May 2020

page(s)

4389-4397

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Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

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cites work

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12 December 2020

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

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12 December 2020

Spatial localization in NMR spectroscopy in vivo

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12 December 2020

Length-dependent gametic CAG repeat instability in the Huntington's disease knock-in mouse

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12 December 2020

Increased vulnerability to 3-nitropropionic acid in an animal model of Huntington's disease.

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12 December 2020

Creatine in humans with special reference to creatine supplementation

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12 December 2020

The molecular structure of mitochondrial contact sites. Their role in regulation of energy metabolism and permeability transition

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12 December 2020

Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease.

1 reference

12 December 2020

Creatine and cyclocreatine attenuate MPTP neurotoxicity

1 reference

12 December 2020

Creatine replacement therapy in guanidinoacetate methyltransferase deficiency, a novel inborn error of metabolism

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12 December 2020

Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice.

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12 December 2020

Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy

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12 December 2020

Functional aspects of creatine kinase in brain.

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12 December 2020

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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12 December 2020

Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo

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12 December 2020

Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

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12 December 2020

Energy metabolism defects in Huntington's disease and effects of coenzyme Q10.

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12 December 2020

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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12 December 2020

Neuroprotective effects of gangliosides may involve inhibition of nitric oxide synthase

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12 December 2020

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

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12 December 2020

Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain

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12 December 2020

Creatine monohydrate increases strength in patients with neuromuscular disease.

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12 December 2020

Widespread expression of Huntington's disease gene (IT15) protein product

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12 December 2020

Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

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12 December 2020

Apoptosis, excitotoxicity, and neuropathology

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12 December 2020

1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers

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12 December 2020

Supplementary creatine as a treatment for gyrate atrophy of the choroid and retina

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12 December 2020

Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes

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12 December 2020

Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.

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12 December 2020

A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

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12 December 2020

Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

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12 December 2020

Altered Ca2 responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies

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12 December 2020

Mitochondrial defect in Huntington's disease caudate nucleus

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12 December 2020

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12 December 2020

Phosphocreatine-dependent Glutamate Uptake by Synaptic Vesicles

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12 December 2020

Neuropathological classification of Huntington's disease

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12 December 2020

Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

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12 December 2020

Preincubation with creatine enhances levels of creatine phosphate and prevents anoxic damage in rat hippocampal slices

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12 December 2020

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

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12 December 2020

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.

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12 December 2020

Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum.

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12 December 2020

Mitochondrial creatine kinase is a prime target of peroxynitrite-induced modification and inactivation.

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12 December 2020

Creatine deficiency in the brain: a new, treatable inborn error of metabolism

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12 December 2020

Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis

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12 December 2020

A randomized, controlled trial of creatine monohydrate in patients with mitochondrial cytopathies

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12 December 2020

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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12 December 2020

Determination of creatine kinase kinetic parameters in rat brain by NMR magnetization transfer. Correlation with brain function.

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12 December 2020

The role of creatine kinase in inhibition of mitochondrial permeability transition

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12 December 2020

Octamer-dimer Transitions of Mitochondrial Creatine Kinase in Heart Disease

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12 December 2020

Huntington's disease gene: regional and cellular expression in brain of normal and affected individuals

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12 December 2020

3-Nitropropionic acid increases the intracellular Ca2 in cultured astrocytes by reverse operation of the Na -Ca2 exchanger

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12 December 2020

Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease

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12 December 2020

Energy metabolism and quantal acetylcholine release: effects of botulinum toxin, 1-fluoro-2,4-dinitrobenzene, and diamide in the Torpedo electric organ

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12 December 2020

Huntington aggregates may not predict neuronal death in Huntington's disease

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12 December 2020

10.1523/JNEUROSCI.20-12-04389.2000

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772461&resulttype=core&format=json

12 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6772461&resulttype=core&format=json

12 May 2020

PubMed publication ID

10844007

1 reference