Targeting ENT1 and adenosine tone for the treatment of Huntington's disease (Q45299960)

11 December 2017

title

Targeting ENT1 and adenosine tone for the treatment of Huntington's disease (English)

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Solute carrier family 29 (nucleoside transporters), member 1

11 December 2017

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Solute carrier family 29 (nucleoside transporters), member 2

GOA release 2020-03-11

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GOA release 2020-03-11

Meng-Syuan Lin

2

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author name string

Yu-Han Kao

1

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11 December 2017

Chiung-Mei Chen

3

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11 December 2017

Yih-Ru Wu

4

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11 December 2017

Hui-Mei Chen

5

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11 December 2017

Hsing-Lin Lai

6

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11 December 2017

Yijuang Chern

7

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11 December 2017

Chun-Jung Lin

8

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11 December 2017

publication date

9 January 2017

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11 December 2017

published in

Human Molecular Genetics

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11 December 2017

volume

26

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11 December 2017

issue

3

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11 December 2017

page(s)

467-478

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11 December 2017

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Amino acid neurotransmitter abnormalities in Huntington's disease and the quinolinic acid animal model of Huntington's disease

21 January 2018

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Short-term effects of tetrabenazine on chorea associated with Huntington's disease

21 January 2018

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Actions of adenosine at its receptors in the CNS: insights from knockouts and drugs

21 January 2018

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Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease

21 January 2018

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A2A receptor knockout worsens survival and motor behaviour in a transgenic mouse model of Huntington's disease

21 January 2018

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Adenosine and glutamate extracellular concentrations and mitogen-activated protein kinases in the striatum of Huntington transgenic mice. Selective antagonism of adenosine A2A receptors reduces transmitter outflow

21 January 2018

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Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease

21 January 2018

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Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy

21 January 2018

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Adenosine dysfunction in epilepsy

21 January 2018

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Adenosine hypothesis of schizophrenia--opportunities for pharmacotherapy

21 January 2018

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Adenosine-based modulation of brain activity.

21 January 2018

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The Role of Extracellular Adenosine in Chemical Neurotransmission in the Hippocampus and Basal Ganglia: Pharmacological and Clinical Aspects

21 January 2018

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A new drug design targeting the adenosinergic system for Huntington's disease

21 January 2018

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Biochemistry, localization and functional roles of ecto-nucleotidases in the nervous system

21 January 2018

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Molecular Biology of Nucleoside Transporters and their Distributions and Functions in the Brain

21 January 2018

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The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29.

21 January 2018

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Nucleoside transporters: from scavengers to novel therapeutic targets

21 January 2018

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Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus.

21 January 2018

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Distinct regional distribution of human equilibrative nucleoside transporter proteins 1 and 2 (hENT1 and hENT2) in the central nervous system

21 January 2018

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Distribution of equilibrative, nitrobenzylthioinosine-sensitive nucleoside transporters (ENT1) in brain

21 January 2018

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Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes

21 January 2018

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

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AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

21 January 2018

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CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model.

21 January 2018

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Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease

21 January 2018

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AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease

21 January 2018

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Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease

21 January 2018

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Neurological abnormalities in a knock-in mouse model of Huntington's disease

21 January 2018

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Adenosine transporter ENT1 regulates the acquisition of goal-directed behavior and ethanol drinking through A2A receptor in the dorsomedial striatum

21 January 2018

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Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotection.

21 January 2018

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Specific progressive cAMP reduction implicates energy deficit in presymptomatic Huntington's disease knock-in mice

21 January 2018

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In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice

21 January 2018

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Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease

21 January 2018

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Characterization of Behavioral, Neuropathological, Brain Metabolic and Key Molecular Changes in zQ175 Knock-In Mouse Model of Huntington's Disease

21 January 2018

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Transgenic rat model of Huntington's disease

21 January 2018

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Astrocyte-derived adenosine modulates increased sleep pressure during inflammatory response.

21 January 2018

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Changes in mRNA expression levels of solute carrier transporters in inflammatory bowel disease patients.

21 January 2018

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A critical role of astrocyte-mediated nuclear factor-κB-dependent inflammation in Huntington's disease

21 January 2018

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Cardiac dysfunction in the R6/2 mouse model of Huntington's disease

21 January 2018

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Equilibrative nucleoside transporter 1 plays an essential role in cardioprotection

21 January 2018

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Absence of equilibrative nucleoside transporter 1 in ENT1 knockout mice leads to altered nucleoside levels following hypoxic challenge

21 January 2018

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Adenosine A(2A) receptors modulate BDNF both in normal conditions and in experimental models of Huntington's disease.

21 January 2018

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What have we learned from gene expression profiles in Huntington's disease?

21 January 2018

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Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

21 January 2018

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Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

21 January 2018

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Extensive changes in DNA methylation are associated with expression of mutant huntingtin.

21 January 2018

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A sensitive HPLC-based method to quantify adenine nucleotides in primary astrocyte cell cultures

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/HMG/DDW402

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11 December 2017

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