Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway (Q45270341)

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English	Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

11 December 2017

Neuroprotection against focal ischemic brain injury by inhibition of c-Jun N-terminal kinase and attenuation of the mitochondrial apoptosis-signaling pathway (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

apoptotic process

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based on heuristic

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author name string

Yanqin Gao

1

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Europe PubMed Central

PubMed publication ID

11 December 2017

Armando P Signore

2

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Europe PubMed Central

PubMed publication ID

11 December 2017

Wei Yin

3

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PubMed publication ID

11 December 2017

Guodong Cao

4

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11 December 2017

Xiao-Ming Yin

5

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Europe PubMed Central

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11 December 2017

Fengyan Sun

6

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Europe PubMed Central

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11 December 2017

Yumin Luo

7

1 reference

Europe PubMed Central

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11 December 2017

Steven H Graham

8

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Europe PubMed Central

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11 December 2017

Jun Chen

9

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11 December 2017

language of work or name

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1 June 2005

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Europe PubMed Central

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11 December 2017

Journal of Cerebral Blood Flow & Metabolism

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11 December 2017

25

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Europe PubMed Central

PubMed publication ID

11 December 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

694-712

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Europe PubMed Central

PubMed publication ID

11 December 2017

MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia

1 reference

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21 January 2018

Expression of c‐fos and c‐jun family genes after focal cerebral ischemia

1 reference

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The specificities of protein kinase inhibitors: an update

1 reference

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Identification of the critical features of a small peptide inhibitor of JNK activity

1 reference

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21 January 2018

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

1 reference

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21 January 2018

Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-Jun N-terminal kinases are activated by ischemia/reperfusion

1 reference

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21 January 2018

A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

1 reference

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CEP-1347/KT-7515, an inhibitor of SAPK/JNK pathway activation, promotes survival and blocks multiple events associated with Abeta-induced cortical neuron apoptosis

1 reference

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Cloning and characterization of rat caspase-9: implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral ischemia

1 reference

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21 January 2018

Intracellular Bax translocation after transient cerebral ischemia: implications for a role of the mitochondrial apoptotic signaling pathway in ischemic neuronal death

1 reference

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21 January 2018

AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties

1 reference

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21 January 2018

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1 reference

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21 January 2018

Transient forebrain ischemia in the adult gerbil is associated with a complex c-Jun response

1 reference

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21 January 2018

Caspase-dependent and caspase-independent signalling of apoptosis in the penumbra following middle cerebral artery occlusion in the adult rat.

1 reference

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21 January 2018

Programmed cell death in cerebral ischemia

1 reference

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Bcl-2 family gene products in cerebral ischemia and traumatic brain injury

1 reference

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21 January 2018

Humanin peptide suppresses apoptosis by interfering with Bax activation

1 reference

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21 January 2018

Transcription factor ATF2 regulation by the JNK signal transduction pathway

1 reference

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21 January 2018

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

1 reference

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21 January 2018

c-Jun N-terminal kinase (JNK) and JNK interacting protein response in rat brain after transient middle cerebral artery occlusion

1 reference

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21 January 2018

AP-1 proteins in the adult brain: facts and fiction about effectors of neuroprotection and neurodegeneration

1 reference

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21 January 2018

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

1 reference

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21 January 2018

Alteration of MAP kinase pathways after transient forebrain ischemia

1 reference

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21 January 2018

Role of mitogen- and stress-activated kinases in ischemic injury

1 reference

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21 January 2018

Regulation of Fas expression by STAT3 and c-Jun is mediated by phosphatidylinositol 3-kinase-AKT signaling.

1 reference

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21 January 2018

A critical role of neural-specific JNK3 for ischemic apoptosis

1 reference

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21 January 2018

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

1 reference

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21 January 2018

To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways

1 reference

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21 January 2018

Targeting JNK for therapeutic benefit: from junk to gold?

1 reference

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Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1 reference

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21 January 2018

JNK and p38 stresskinases--degenerative effectors of signal-transduction-cascades in the nervous system

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

21 January 2018

Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

21 January 2018

14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

21 January 2018

Delayed neuronal cell death in the rat hippocampus is mediated by the mitogen-activated protein kinase signal transduction pathway

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

21 January 2018

BID mediates neuronal cell death after oxygen/ glucose deprivation and focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

21 January 2018

JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

21 January 2018

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

21 January 2018

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

21 January 2018

The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax

1 reference

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21 January 2018

A convoluted way to die.

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

21 January 2018

c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

21 January 2018

AP-1 as a regulator of cell life and death

1 reference

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21 January 2018

Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice

1 reference

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21 January 2018

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

21 January 2018

JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

21 January 2018

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

21 January 2018

Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

21 January 2018

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

21 January 2018

Bid-mediated mitochondrial pathway is critical to ischemic neuronal apoptosis and focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

21 January 2018

Apoptosis in the nervous system

1 reference

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21 January 2018

A test for detecting long-term sensorimotor dysfunction in the mouse after focal cerebral ischemia

1 reference

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21 January 2018

Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

7 January 2021

based on heuristic

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Expression of the apoptosis-effector gene, Bax, is up-regulated in vulnerable hippocampal CA1 neurons following global ischemia

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

7 January 2021

based on heuristic

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Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of cell death-associated phospho-c-Jun and p53-activated gene 608 in hippocampal CA1 neurons following global ischemia

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of the c-Jun N-terminal kinase signaling pathway by the mixed lineage kinase inhibitor CEP-1347 (KT7515) preserves metabolism and growth of trophic factor-deprived neurons.

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury.

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

7 January 2021

based on heuristic

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Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia

1 reference

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7 January 2021

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Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo

1 reference

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7 January 2021

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Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase Deficiency

1 reference

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7 January 2021

based on heuristic

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Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase.

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Bcl-xL is an antiapoptotic regulator for postnatal CNS neurons.

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway.

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuroprotective agent chlomethiazole attenuates c-fos, c-jun, and AP-1 activation through inhibition of p38 MAP kinase

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial release of cytochrome c corresponds to the selective vulnerability of hippocampal CA1 neurons in rats after transient global cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of mitogen-activated protein kinases after transient forebrain ischemia in gerbil hippocampus

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Neuroprotective effect of alpha-phenyl-N-tert-butylnitrone in gerbil hippocampus is mediated by the mitogen-activated protein kinase pathway and heat shock proteins

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of p38MAPK in microglia after ischemia.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of mitogen-activated protein kinases after permanent cerebral artery occlusion in mouse brain

1 reference

https://api.crossref.org/works/10.1038/SJ.JCBFM.9600062

7 January 2021

based on heuristic

inferred from DOI database lookup

Amyloid-beta induces Smac release via AP-1/Bim activation in cerebral endothelial cells.

1 reference

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7 January 2021

based on heuristic

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Bcl-2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase-3 activity.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

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10.1038/SJ.JCBFM.9600062

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 December 2017

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