Dysregulated pH: a perfect storm for cancer progression. (Q45255109)

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10 February 2020

review article

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title

Dysregulated pH: a perfect storm for cancer progression (English)

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10 February 2020

3

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10 February 2020

Bradley A Webb

series ordinal

1

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10 February 2020

4

Diane L Barber

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10 February 2020

author name string

Michael Chimenti

series ordinal

2

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10 February 2020

language of work or name

English

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publication date

11 August 2011

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10 February 2020

published in

Nature Reviews Cancer

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10 February 2020

volume

11

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10 February 2020

issue

9

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10 February 2020

page(s)

671-677

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Hallmarks of Cancer: The Next Generation

10 February 2020

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The role of disturbed pH dynamics and the Na /H exchanger in metastasis.

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Effects of growth factors on intracellular pH regulation

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A pH-sensitive and voltage-dependent proton conductance in the plasma membrane of macrophages

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Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H( ) translocation

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Alterations of intracellular pH homeostasis in apoptosis: origins and roles

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Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

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Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition

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Intracellular acidification delays hormonal G2/M transition and inhibits G2/M transition triggered by thiophosphorylated MAPK in Xenopus oocytes

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DNA damage-induced Bcl-xL deamidation is mediated by NHE-1 antiport regulated intracellular pH.

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The role of cell swelling in the stimulation of glycogen synthesis by insulin

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Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes

31 March 2020

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Kinetics of enamel dissolution during formation of incipient caries-like lesions

31 March 2020

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Regulation of muscle phosphofructokinase by physiological concentrations of bisphosphorylated hexoses: effect of alkalinization

31 March 2020

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The crystal structures of eukaryotic phosphofructokinases from baker's yeast and rabbit skeletal muscle

31 March 2020

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Purification and properties of pyruvate kinase type M2 from rat lung

31 March 2020

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Differential behavior of missense mutations in the intersubunit contact domain of the human pyruvate kinase M2 isozyme

31 March 2020

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

31 March 2020

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Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

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Brick by brick: metabolism and tumor cell growth

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Expression profile of genes regulated by activity of the Na-H exchanger NHE1

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The genomic analysis of lactic acidosis and acidosis response in human cancers

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Novel invadopodia components revealed by differential proteomic analysis.

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Assembly and regulation of a glycolytic enzyme complex on the human erythrocyte membrane

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Mapping of glycolytic enzyme-binding sites on human erythrocyte band 3.

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Modulation of cell motility by spatial repositioning of enzymatic ATP/ADP exchange capacity

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31 March 2020

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Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

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Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding

31 March 2020

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Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor

31 March 2020

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Acid-Induced Equilibrium Folding Intermediate of Human Platelet Profilin†

31 March 2020

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Twinfilin is an actin-filament-severing protein and promotes rapid turnover of actin structures in vivo

31 March 2020

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Characterizing a partially folded intermediate of the villin headpiece domain under non-denaturing conditions: contribution of His41 to the pH-dependent stability of the N-terminal subdomain

31 March 2020

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Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling

31 March 2020

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Characterization of an Actin-binding Site within the Talin FERM Domain

31 March 2020

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The effect of intact talin and talin tail fragment on actin filament dynamics and structure depends on pH and ionic strength

31 March 2020

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Interaction of talin with actin: sensitive modulation of filament crosslinking activity

31 March 2020

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Cofilin determines the migration behavior and turning frequency of metastatic cancer cells

31 March 2020

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A common cofilin activity cycle in invasive tumor cells and inflammatory cells

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Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch

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31 March 2020

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Protons extruded by NHE1: digestive or glue?

31 March 2020

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Migration of human melanoma cells depends on extracellular pH and Na /H exchange

31 March 2020

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Mislocalized scaffolding by the Na-H exchanger NHE1 dominantly inhibits fibronectin production and TGF-beta activation

31 March 2020

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Acidic Extracellular pH Promotes Activation of Integrin αvβ3

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Tumour–stromal interactions in acid-mediated invasion: A mathematical model

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Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption.

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A rationalization of the acidic pH dependence for stromelysin-1 (Matrix metalloproteinase-3) catalysis and inhibition

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CD44 interaction with Na -H exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion

31 March 2020

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Cathepsin B mediates the pH-dependent proinvasive activity of tumor-shed microvesicles

31 March 2020

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Bicarbonate increases tumor pH and inhibits spontaneous metastases

31 March 2020

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Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics

31 March 2020

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31 March 2020

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Tumor acidity, ion trapping and chemotherapeutics. II. pH-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents

31 March 2020

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Impact of extracellular acidity on the activity of P-glycoprotein and the cytotoxicity of chemotherapeutic drugs

31 March 2020

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P-glycoprotein preferentially effluxes anthracyclines containing free basic versus charged amine

31 March 2020

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Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

31 March 2020

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The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models

31 March 2020

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31 March 2020

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Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation

31 March 2020

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GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery

31 March 2020

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Design of Environment‐Sensitive Supramolecular Assemblies for Intracellular Drug Delivery: Polymeric Micelles that are Responsive to Intracellular pH Change

31 March 2020

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Diverse somatic mutation patterns and pathway alterations in human cancers

31 March 2020

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A novel mechanism of tumorigenesis involving pH-dependent destabilization of a mutant p53 tetramer

31 March 2020

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Crippling p53 activities via knock-in mutations in mouse models

31 March 2020

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Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

31 March 2020

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Na /H exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes.

31 March 2020

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Hypoxia-inducible expression of tumor-associated carbonic anhydrases

31 March 2020

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12 December 2020

The role of pH dynamics and the Na /H antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin--one single nature

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12 December 2020

Tumor-associated carbonic anhydrases and their clinical significance.

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12 December 2020

Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: an orally active anti-cancer drug waiting for its call-of-duty?

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12 December 2020

Pericellular pH affects distribution and secretion of cathepsin B in malignant cells

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12 December 2020

Enzymatic regulation of glycolysis and gluconeogenesis in rabbit periodontal ligament under various physiological pH conditions

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12 December 2020

Carbonic anhydrase (CA IX) expression, a potential new intrinsic marker of hypoxia: correlations with tumor oxygen measurements and prognosis in locally advanced carcinoma of the cervix

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12 December 2020

In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH.

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12 December 2020

Effect of pH on the kinetics of frog muscle phosphofructokinase

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12 December 2020

pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth.

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12 December 2020

Phosphofructokinase. III. Correlation of the regulatory kinetic and molecular properties of the rabbit muscle enzyme

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12 December 2020

Matrix metalloproteinase-3 (stromelysin-1). Identification as the cartilage acid metalloprotease and effect of pH on catalytic properties and calcium affinity

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12 December 2020