Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia (Q45209344)

10 December 2017

title

Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia (English)

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10 December 2017

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D J P M Stumpel

1

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10 December 2017

P Schneider

2

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10 December 2017

L Seslija

3

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10 December 2017

H Osaki

4

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10 December 2017

O Williams

5

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R Pieters

6

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R W Stam

7

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10 December 2017

publication date

21 October 2011

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10 December 2017

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10 December 2017

volume

26

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10 December 2017

issue

4

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10 December 2017

page(s)

682-692

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A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial.

10 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

New insights to the MLL recombinome of acute leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Definitive hematopoiesis requires the mixed-lineage leukemia gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

The Connectivity Map: a new tool for biomedical research

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

D-HPLC analysis of the entire FLT3 gene in MLL rearranged and hyperdiploid acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Infant acute lymphoblastic leukemia: Lessons learned and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Mechanism for ubiquitylation of the leukemia fusion proteins AML1-ETO and PML-RARalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

MLL targets SET domain methyltransferase activity to Hox gene promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Reflecting on 25 years with MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Leukemogenic transformation by HOXA cluster genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

The RUNX genes: gain or loss of function in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

The GTPase Ran: regulation of cell life and potential roles in cell transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Expression and role of DJ-1 in leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

MLL-aberrant leukemia: complete cytogenetic remission following treatment with a histone deacetylase inhibitor (HDACi)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/LEU.2011.278

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Identifiers

DOI

10.1038/LEU.2011.278

1 reference

Dimensions Publication ID

10 December 2017

1045480274

0 references

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