Response to lenalidomide in myelodysplastic syndromes with del(5q): influence of cytogenetics and mutations. (Q45155324)

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29 February 2020

title

Response to lenalidomide in myelodysplastic syndromes with del(5q): influence of cytogenetics and mutations (English)

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M J Calasanz

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Maria Diez-Campelo

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Eva Lumbreras

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Lourdes Florensa

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Jesus Maria Hernandez Rivas

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author name string

Mar Mallo

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Mónica Del Rey

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Mariam Ibáñez

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M José Larráyoz

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Carmen Pedro

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Andrés Jerez

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Jaroslaw Maciejewski

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Dolors Costa

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Meritxell Nomdedeu

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Teresa González-Martínez

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Isabel Marugán

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Esperanza Such

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José Cervera

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Juan C Cigudosa

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Sara Alvarez

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Francesc Solé

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language of work or name

English

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publication date

25 April 2013

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British Journal of Haematology

29 February 2020

published in

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volume

162

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issue

1

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page(s)

74-86

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Recent clinical studies of the immunomodulatory drug (IMiD) lenalidomide

29 February 2020

cites work

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Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias.

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Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes.

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An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome

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Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

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Molecular definition of chromosome arm 5q deletion end points and detection of hidden aberrations in patients with myelodysplastic syndromes and isolated del(5q) using oligonucleotide array CGH.

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Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression

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TP53 Mutations in Low-Risk Myelodysplastic Syndromes With del(5q) Predict Disease Progression

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Treatment by Lenalidomide in lower risk myelodysplastic syndrome with 5q deletion--the GFM experience

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Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies.

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Biological activity of lenalidomide in myelodysplastic syndromes with del5q: results of gene expression profiling from a multicenter phase II study.

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IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication

21 January 2018

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WHO-defined 'myelodysplastic syndrome with isolated del(5q)' in 88 consecutive patients: survival data, leukemic transformation rates and prevalence of JAK2, MPL and IDH mutations

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Relationship of treatment-related cytopenias and response to lenalidomide in patients with lower-risk myelodysplastic syndromes

21 January 2018

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Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies

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Correlation of clinical response and response duration with miR-145 induction by lenalidomide in CD34( ) cells from patients with del(5q) myelodysplastic syndrome

21 January 2018

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Small supernumerary marker chromosome causing partial trisomy 6p in a child with craniosynostosis.

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Lenalidomide promotes p53 degradation by inhibiting MDM2 auto-ubiquitination in myelodysplastic syndrome with chromosome 5q deletion

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Impact of adjunct cytogenetic abnormalities for prognostic stratification in patients with myelodysplastic syndrome and deletion 5q

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Thrombocytopenia at diagnosis as an important negative prognostic marker in isolated 5q− MDS (IPSS low and intermediate-1)

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