Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse. (Q45106002)

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scientific article published in October 2004

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English	Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse.	scientific article published in October 2004

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4 January 2020

Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse (English)

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Matthew Brown

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Tom Jacobs

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Britta Eickholt

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Giovanna Ferrari

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Mabel Teo

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Clinton Monfries

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Thomas Leung

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4 January 2020

Louis Lim

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4 January 2020

Christine Hall

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1 October 2004

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4 January 2020

Journal of Neuroscience

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4 January 2020

8994-9004

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4 January 2020

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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inferred from PubMed ID database lookup

Sema3A-induced growth-cone collapse is mediated by Rac1 amino acids 17-32.

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Semaphorin3A enhances endocytosis at sites of receptor-F-actin colocalization during growth cone collapse.

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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The semaphorin 3A receptor may directly regulate the activity of small GTPases.

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

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Phorbol esters and related analogs regulate the subcellular localization of beta 2-chimaerin, a non-protein kinase C phorbol ester receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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alpha2-chimaerin, a Cdc42/Rac1 regulator, is selectively expressed in the rat embryonic nervous system and is involved in neuritogenesis in N1E-115 neuroblastoma cells.

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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CRMP-2 induces axons in cultured hippocampal neurons

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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GSK3 takes centre stage more than 20 years after its discovery

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Collapsin response mediator protein switches RhoA and Rac1 morphology in N1E-115 neuroblastoma cells and is regulated by Rho kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse.

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12 December 2020

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Essential role of type I(alpha) phosphatidylinositol 4-phosphate 5-kinase in neurite remodeling

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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An inactive pool of GSK-3 at the leading edge of growth cones is implicated in Semaphorin 3A signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Rac1-mediated endocytosis during ephrin-A2- and semaphorin 3A-induced growth cone collapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CRMP-2 binds to tubulin heterodimers to promote microtubule assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

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Nerve growth cone guidance mediated by G protein-coupled receptors.

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

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Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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The specificities of protein kinase inhibitors: an update

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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ArhGAP15, a novel human RacGAP protein with GTPase binding property

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Cdk5 is essential for synaptic vesicle endocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Structural bases for CRMP function in plexin-dependent semaphorin3A signaling

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Alpha-chimaerin exists in a functional complex with the Cdk5 kinase in brain

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Semaphorin 3A stimulates neurite extension and regulates gene expression in PC12 cells

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https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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MAP1B is required for Netrin 1 signaling in neuronal migration and axonal guidance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The activity of the plexin-A1 receptor is regulated by Rac

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diversity and versatility of GTPase activating proteins for the p21rho subfamily of ras G proteins detected by a novel overlay assay.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Bcr encodes a GTPase-activating protein for p21rac

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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TOAD-64, a gene expressed early in neuronal differentiation in the rat, is related to unc-33, a C. elegans gene involved in axon outgrowth

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

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Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysophosphatidic acid-induced neurite retraction in PC12 cells: control by phosphoinositide-Ca2 signaling and Rho

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rac1 mediates collapsin-1-induced growth cone collapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta2-chimaerin is a high affinity receptor for the phorbol ester tumor promoters

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of neurofilament proteins with neuronal Cdk5 activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Membrane targeting of p21-activated kinase 1(PAK1) induces neurite outgrowth from PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collapsin Response Mediator Protein-2 Is Associated with Neurofibrillary Tangles in Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15483118

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.3184-04.2004

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4 January 2020

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4 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15483118 AND SRC:MED&resulttype=core&format=json

4 January 2020

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