The Past, Present, and Future of Phosphodiesterase-4 Modulation for Age-Induced Memory Loss (Q45068631)

9 December 2017

title

The Past, Present, and Future of Phosphodiesterase-4 Modulation for Age-Induced Memory Loss (English)

1 reference

9 December 2017

Rolf T Hansen

1

1 reference

9 December 2017

Han-Ting Zhang

series ordinal

2

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9 December 2017

publication date

1 January 2017

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9 December 2017

published in

Advances in neurobiology

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9 December 2017

volume

17

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9 December 2017

page(s)

169-199

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Long lasting effects of predator stress on pCREB expression in brain regions involved in fearful and anxious behavior

9 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Protein kinase A as a therapeutic target for memory disorders: rationale and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Dynamic Network Connectivity: A new form of neuroplasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Selective Phosphodiesterase 4B Inhibitors: A Review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2 -triggered membrane association with selectivity for interaction with phosphatidic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

PDE4D and PDE4B Function in Distinct Subcellular Compartments in Mouse Embryonic Fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Properties of adenylate cyclase from senescent rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Epac proteins: multi-purpose cAMP targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Long-term memory for place learning is facilitated by expression of cAMP response element-binding protein in the dorsal hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Organization of the cerebral cortex. III. A study of aging in the human cerebral cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Cyclic adenosine monophosphate as an endogenous modulator of the amyloid-β precursor protein metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

21 January 2018

The many faces of CREB

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Subcellular localization of rolipram-sensitive, cAMP-specific phosphodiesterases. Differential targeting and activation of the splicing variants derived from the PDE4D gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Identification and characterization of novel mouse PDE4D isoforms: molecular cloning, subcellular distribution and detection of isoform-specific intracellular localization signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25-35 or Aβ1-40 peptide in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationales

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Genome-wide analysis of CREB target genes reveals a core promoter requirement for cAMP responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Cyclic AMP-specific PDE4 phosphodiesterases as critical components of cyclic AMP signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Adenylyl cyclase activity in postmortem human brain: evidence of altered G protein mediation in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Neurons from senescence-accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Regulation of cAMP-specific phosphodiesterases type 4B and 4D (PDE4) splice variants by cAMP signaling in primary cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Differential expression and regulation of the cAMP-selective phosphodiesterase type 4A splice variants in rat brain by chronic antidepressant administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Cloning and characterization of mammalian homologs of the Drosophila dunce gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Differential association of phosphodiesterase 4D isoforms with beta2-adrenoceptor in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Brain regional levels of adenosine and adenosine nucleotides in rats killed by high-energy focused microwave irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Aging of the brain, entropy, and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Longitudinal pattern of regional brain volume change differentiates normal aging from MCI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Endogenous beta-amyloid peptide synthesis modulates cAMP response element-regulated gene expression in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Brain distribution of four rat homologues of the Drosophila dunce cAMP phosphodiesterase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Levels of phosphodiesterase 4A and 4B are altered by chronic treatment with psychotropic medications in rat frontal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

CREB: a major mediator of neuronal neurotrophin responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Structural basis for the design of selective phosphodiesterase 4B inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Inflammation and oxidative damage in Alzheimer s disease friend or foe

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Potential CRE suppression by familial Alzheimer's mutants of APP independent of adenylyl cyclase regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

A stereological study of the numbers of neurons and glia in the primary visual cortex across the lifespan of male and female rhesus monkeys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Epac: defining a new mechanism for cAMP action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Discovery of triazines as selective PDE4B versus PDE4D inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Senescent-induced dysregulation of cAMP/CREB signaling and correlations with cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Effects of aging on signal transmission and transduction systems in the gerbil brain: morphological and autoradiographic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Brain-derived neurotrophic factor, phosphorylated cyclic AMP response element binding protein and neuropeptide Y decline as early as middle age in the dentate gyrus and CA1 and CA3 subfields of the hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Genetic variants of phosphodiesterase 4D gene are associated with an enhanced risk for ischemic stroke in young Chinese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Emetic, central nervous system, and pulmonary activities of rolipram in the dog.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Rolipram in major depressive disorder: results of a double-blind comparative study with imipramine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Increased cAMP immunostaining in cerebral vessels in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Reimagining Alzheimer's disease--an age-based hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Phosphodiesterase 4D single-nucleotide polymorphism 83 and cognitive dysfunction in carotid endarterectomy patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19 [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Ameliorating effects of rolipram on experimentally induced impairments of learning and memory in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

N termini of apPDE4 isoforms are responsible for targeting the isoforms to different cellular membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Lipopolysaccharide administration in vivo induces differential expression of cAMP-specific phosphodiesterase 4B mRNA splice variants in the mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Comparison of cAMP-specific phosphodiesterase mRNAs distribution in mouse and rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

An evolutionary analysis of cAMP-specific Phosphodiesterase 4 alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Differential changes of cAMP-dependent protein kinase activity and 3H-cAMP binding sites in rat hippocampus during maturation and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

A non-radioactive assay for the cAMP-dependent protein kinase activity in rat brain homogenates and age-related changes in hippocampus and cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Dynamic interaction of cAMP with the Rap guanine-nucleotide exchange factor Epac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Stress Leads to Contrasting Effects on the Levels of Brain Derived Neurotrophic Factor in the Hippocampus and Amygdala

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

cAMP signalling mechanisms with aging in the Ceratitis capitata brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Amelioration of recognition memory impairment associated with iron loading or aging by the type 4-specific phosphodiesterase inhibitor rolipram in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Different mutations in PDE4D associated with developmental disorders with mirror phenotypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Identification and molecular characterization of a novel PDE4D11 cAMP-specific phosphodiesterase isoform.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Evidence for selective loss of brain dopamine- and histamine-stimulated adenylate cyclase activities in rabbits with aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

A peripheral and an intrinsic enzyme constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Layers of organization of cAMP microdomains in a simple cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Increased cerebrospinal fluid cAMP levels in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Advances in targeting cyclic nucleotide phosphodiesterases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Changes in PDE4D isoforms in the hippocampus of a patient with advanced Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

The novel long PDE4A10 cyclic AMP phosphodiesterase shows a pattern of expression within brain that is distinct from the long PDE4A5 and short PDE4A1 isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

PDE4D phosphorylation: A coincidence detector integrating multiple signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Differential distribution of PDE4D splice variant mRNAs in rat brain suggests association with specific pathways and presynaptical localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Effects of age and spatial learning on adenylyl cyclase mRNA expression in the mouse hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Tumor Necrosis Factor-alpha and the Roles it Plays in Homeostatic and Degenerative Processes Within the Central Nervous System

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Differential distribution of four hyperpolarization-activated cation channels in mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Brain fixation for analysis of brain lipid-mediators of signal transduction and brain eicosanoids requires head-focused microwave irradiation: an historical perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Epac mediates cyclic AMP-dependent axon growth, guidance and regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

cAMP-dependent axon guidance is distinctly regulated by Epac and protein kinase A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Activation of CREB in the Nucleus Accumbens Shell Produces Anhedonia and Resistance to Extinction of Fear in Rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Focused microwave irradiation of the brain preserves in vivo protein phosphorylation: comparison with other methods of sacrifice and analysis of multiple phosphoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Age-associated decrease of adenylate cyclase activity in rat myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Age-associated decrease in the catalytic unit activitiy of rat myocardial adenylate cyclase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Evidence for global reduction in brain cyclic adenosine monophosphate signaling in depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Reduced basal and stimulated (isoprenaline, Gpp(NH)p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Epac signaling is required for hippocampus-dependent memory retrieval

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

PDE4B as a microglia target to reduce neuroinflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and[3H]rolipram binding autoradiography. Comparison with monkey and rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Feature article: are neurons lost from the primate cerebral cortex during normal aging?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Alteration of CREB phosphorylation and spatial memory deficits in aged 129T2/Sv mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Downregulation of CREB expression in Alzheimer's brain and in Aβ-treated rat hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Effect of aging on cyclic AMP levels and adenylate cyclase and phosphodiesterase activities in the rat corpus striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Characterization of the memory gene dunce of Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Dysregulation of protein kinase a signaling in the aged prefrontal cortex: new strategy for treating age-related cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Alpha2A-adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Brain cyclic AMP and memory in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Distinct phosphodiesterase-4D variants integrate into protein kinase A-based signaling complexes in cardiac and vascular myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Dimerization of the type 4 cAMP-specific phosphodiesterases is mediated by the upstream conserved regions (UCRs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

PDE4 as a target for cognition enhancement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Assessing the emetic potential of PDE4 inhibitors in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Epac: effectors and biological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D-knockout (PDE4D) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Comparison of recombinant human PDE4 isoforms: interaction with substrate and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

A longitudinal study of brain volume changes in normal aging using serial registered magnetic resonance imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Cyclic AMP and cyclic GMP accumulation in vitro in brain regions of young, old and aged rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Adenylyl cyclase activity in Alzheimer's disease brain: stimulatory and inhibitory signal transduction pathways are differently affected

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Interaction of metoprolol with lorazepam and bromazepam

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

The cAMP-specific phosphodiesterase 4B mediates Abeta-induced microglial activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Ischemic stroke risk in a southeastern Chinese population: Insights from 5-lipoxygenase activating protein and phosphodiesterase 4D single-nucleotide polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Absolute number of neurons and thickness of the cerebral cortex during aging, senile and vascular dementia, and Pick's and Alzheimer's diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Interaction of neuropeptide Y and corticotropin-releasing factor signaling pathways in AR-5 amygdalar cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Reversal of long-term dendritic spine alterations in Alzheimer disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Use of microwaves for rapid fixation of tissues in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Ca2 Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Life span and synapses: will there be a primary senile dementia?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Influence of aging on rolipram-sensitive phosphodiesterase activity and [3H]rolipram binding in the rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Impairment of CREB phosphorylation in the hippocampal CA1 region of the senescence-accelerated mouse (SAM) P8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Working memory deficits and related disinhibition of the cAMP/PKA/CREB are alleviated by prefrontal α4β2*-nAChRs stimulation in aged mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Sleep deprivation impairs cAMP signalling in the hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

PDE4 control on cAMP/PKA compartmentation revealed by biosensor imaging in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Potential antidepressant activity of rolipram and other selective cyclic adenosine 3′,5′-monophosphate phosphodiesterase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Rolipram, a novel antidepressant drug, reverses the hypothermia and hypokinesia of monoamine-depleted mice by an action beyond postsynaptic monoamine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Effects of cyclic adenosine monophosphate response element binding protein overexpression in the basolateral amygdala on behavioral models of depression and anxiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

The phosphodiesterase-4 inhibitor rolipram reverses Aβ-induced cognitive impairment and neuroinflammatory and apoptotic responses in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

The effect of resveratrol on beta amyloid-induced memory impairment involves inhibition of phosphodiesterase-4 related signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Memory impairment in cognitively impaired aged rats associated with decreased hippocampal CREB phosphorylation: reversal by procyanidins extracted from the lotus seedpod

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Hippocampal level of neural specific adenylyl cyclase type I is decreased in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Association between phosphodiesterase 4D polymorphism SNP83 and ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Cyclic AMP-specific phosphodiesterase-4 as a target for the development of antidepressant drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

Levels of adenosine 3',5'-cyclic monophosphate in the cerebral cortex of aging rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007/978-3-319-58811-7_7

10.1007/978-3-319-58811-7_7

21 January 2018

Identifiers

DOI

1 reference

release_7erhbrhrbbbjzj27q7wgg6zuge

9 December 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7erhbrhrbbbjzj27q7wgg6zuge

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference